CAZyme Information: MGYG000004858_00697

Basic Information

• Lineage: Bacteria; Firmicutes_C; Negativicutes; Veillonellales; Veillonellaceae; Veillonella
• CAZyme ID: MGYG000004858_00697
• CAZy Family: GT51
• CAZyme Description: Penicillin-binding protein 1F

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
625		67803.95	5.8215

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000004858	906876	MAG	China	Asia

• Gene Location: Start: 149; End: 2026 Strand: -

Full Sequence      

MHGNLITTVHSSENRLPIPLKDVPKDLQNAFVATEDSRFYTHHGIDPIGILRAIWVNIVH
SGVSEGGSTITQQLARNAFLSQDRTFKRKISEALLALKIEQHYTKDEILEMYMNQIYFGQ
GAYGVQSASHVYFGKDASQLTLAQAALIAGLPQSPNYYSPFNDLEASKKRQAVVLGQMVK
YGYITQEQADEARQADLGLVAKQEQTHEKSNASYFINYVIAQVSEKYGDDAIYKDGLKIY
TTLDMDAQNAAVAAMQNLPDFYTDKNGLHQPQGAIVAMNPHNGYIVAMVGGRGDDAFNRA
TQAERQPGSAMKPFVYLAAIQSGKTPGSIVDDSPVTFGSWSPKNYENDFVGNITYRYALQ
HSRNVAAVKIADEVGMTKVIKLAKEMGISTLTDQDYNLSTALGGLTHGVTPLEMVQAYGV
LANGGIKVQPTAILKIVDRNGQVVEENSIQEKRVVDEKDAAIITNMLESVINGGTGGNAA
IGRPAAGKTGTTDDSKDAWFVGYTPDLVAAIWIGDDYGSETLRGMTGGDTPAIMWGQFMA
NALANTPASDFSVPASAQSAVSEGYYNPVKAQPKKEAAKDEKADKKDDKDKSKDEAVKDD
SGSKDDATEQKSNSSKSKKSSKKDR

Enzyme Prediction     

No EC number prediction in MGYG000004858_00697.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT51	3	179	3.8e-74	0.9887005649717514

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
COG0744	MrcB	0.0	4	551	65	605	Membrane carboxypeptidase (penicillin-binding protein) [Cell wall/membrane/envelope biogenesis].
COG5009	MrcA	0.0	3	556	56	732	Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis].
TIGR02074	PBP_1a_fam	0.0	14	545	1	531	penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
TIGR02071	PBP_1b	1.33e-135	5	542	135	682	penicillin-binding protein 1B. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of a particular bifunctional transglycosylase/transpeptidase in E. coli and other Proteobacteria, designated penicillin-binding protein 1B. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
PRK11636	mrcA	9.79e-121	15	555	66	797	penicillin-binding protein 1a; Provisional

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
BBU36295.1	0.0	1	625	72	696
VEG93401.1	0.0	1	625	72	696
CAB1275508.1	0.0	1	581	72	652
QQB17780.1	0.0	1	581	72	652
SNU98291.1	0.0	1	581	72	652

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
4OON_A	1.35e-95	15	554	39	734	Crystalstructure of PBP1a in complex with compound 17 ((4Z,8S,11E,14S)-5-(2-amino-1,3-thiazol-4-yl)-14-(5,6-dihydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-8-formyl-2-methyl-6-oxo-3,10-dioxa-4,7,11-triazatetradeca-4,11-diene-2,12,14-tricarboxylic acid) [Pseudomonas aeruginosa PAO1]
3UDF_A	2.06e-92	4	558	28	731	ChainA, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDF_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii]
3ZG8_B	6.15e-85	98	558	2	476	CrystalStructure of Penicillin Binding Protein 4 from Listeria monocytogenes in the Ampicillin bound form [Listeria monocytogenes],3ZG9_B Crystal Structure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the Cefuroxime bound form [Listeria monocytogenes],3ZGA_B Crystal Structure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the Carbenicillin bound form [Listeria monocytogenes]
7U4H_A	1.03e-79	4	537	29	755	ChainA, Penicillin-binding protein 1A (Pbp1a) [Chlamydia trachomatis D/UW-3/CX],7U4H_B Chain B, Penicillin-binding protein 1A (Pbp1a) [Chlamydia trachomatis D/UW-3/CX]
5U2G_A	1.48e-79	3	554	29	769	2.6Angstrom Resolution Crystal Structure of Penicillin-Binding Protein 1A from Haemophilus influenzae [Haemophilus influenzae Rd KW20],5U2G_B 2.6 Angstrom Resolution Crystal Structure of Penicillin-Binding Protein 1A from Haemophilus influenzae [Haemophilus influenzae Rd KW20]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
O66874	8.83e-119	3	554	52	679	Penicillin-binding protein 1A OS=Aquifex aeolicus (strain VF5) OX=224324 GN=mrcA PE=1 SV=1
P38050	1.56e-107	2	516	55	571	Penicillin-binding protein 1F OS=Bacillus subtilis (strain 168) OX=224308 GN=pbpF PE=2 SV=2
O87579	1.74e-105	6	554	59	717	Penicillin-binding protein 1A OS=Neisseria lactamica OX=486 GN=mrcA PE=3 SV=1
P70997	1.09e-104	3	554	62	619	Penicillin-binding protein 2D OS=Bacillus subtilis (strain 168) OX=224308 GN=pbpG PE=2 SV=3
Q5FAC7	2.74e-103	9	565	62	728	Penicillin-binding protein 1A OS=Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090) OX=242231 GN=mrcA PE=3 SV=3

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000069	0.000001	0.000000	0.000000	0.000000	0.000000

TMHMM  Annotations     

There is no transmembrane helices in MGYG000004858_00697.