CAZyme Information: MGYG000004878_02593

Basic Information

• Species: Butyricimonas sp900184685
• Lineage: Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Marinifilaceae; Butyricimonas; Butyricimonas sp900184685
• CAZyme ID: MGYG000004878_02593
• CAZy Family: GT51
• CAZyme Description: Penicillin-binding protein 1A

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
762		86292.35	7.5402

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000004878	4513844	MAG	China	Asia

• Gene Location: Start: 41; End: 2329 Strand: +

Full Sequence      

MFVIFVGGIFFFFYLVSDGKLGFMPTFEELENPNNSFATEVYSADGKIIGKYFEGSENRR
YMEYKDIPQSVIDALIATEDVRFYEHSGIDVRGLFRVAKGMATGNSAAGGGSTITQQLAK
MLFPREANQNFMELAMRKFREWVIAVKLEKSYTKEEIITMYLNKFDFLNLAVGINSAANI
YFSTSPDSLRVEQSAMLVGMAKNPSLFNPVRRPDKTLGRRNVVLSQMLKYDKISETEYDS
LKNLPLGLDFHKEDHKEGIATYFREYMRLYLTANKPEKKNYKWNKDQYAVDSLAWERDPL
YGWCNKNLKSDGSRYNIYTDGLKIYTTLDSRMQKYAEEAVTEHLGGTLQPTFMAERKHKA
NPPFSNDLTKEAINEILNTSIRRTERYRSMNKAGKSFAEIKKEFAKPIAMSVFTWNGVRD
TTMSPLDSLKHYKSFFRAGFMAMEPATGHIKAYVGGPNYHYFQYDMVSTGKRQIGSTIKP
ILYTLAMQEGLEPCQKVLNVQQTFVLPDGTTWTPRNSTNKREGEMVTLKWGLANSVNNIS
GWVLKQFTPEAVVQMAHRMGINSFIDPVPAIFLGSSEVSVKEMVSAFSVYANKGVYNSPI
MVTKIEDKYGNLLATFQPESREVITENTAYLMANLLKGVIDEGTGIRLRYRYKFTNPIGG
KTGTTQNHSDGWFIGITPDLAGGVWVGAEDRSIHFQNLANGQGASMALPIWALFMQKVYA
DKSLAVPQRDFEKPNGVNKVLDCDDEGDEVVTESDFVDEIFD

Enzyme Prediction     

No EC number prediction in MGYG000004878_02593.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT51	46	227	3.9e-59	0.9830508474576272

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
TIGR02074	PBP_1a_fam	3.77e-152	58	721	1	531	penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG5009	MrcA	1.43e-146	24	740	34	736	Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis].
COG0744	MrcB	5.51e-144	23	737	40	615	Membrane carboxypeptidase (penicillin-binding protein) [Cell wall/membrane/envelope biogenesis].
TIGR02071	PBP_1b	1.38e-84	30	738	117	696	penicillin-binding protein 1B. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of a particular bifunctional transglycosylase/transpeptidase in E. coli and other Proteobacteria, designated penicillin-binding protein 1B. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
PRK11636	mrcA	2.99e-77	40	740	49	802	penicillin-binding protein 1a; Provisional

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QRO50642.1	0.0	1	762	15	777
AZS30376.1	0.0	1	762	17	779
SNV41702.1	0.0	3	745	15	756
ADY33734.1	0.0	3	745	15	756
BAX80294.1	0.0	12	746	42	775

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
3UDF_A	5.28e-72	40	715	22	712	ChainA, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDF_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii]
4OON_A	1.29e-68	28	737	10	737	Crystalstructure of PBP1a in complex with compound 17 ((4Z,8S,11E,14S)-5-(2-amino-1,3-thiazol-4-yl)-14-(5,6-dihydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-8-formyl-2-methyl-6-oxo-3,10-dioxa-4,7,11-triazatetradeca-4,11-diene-2,12,14-tricarboxylic acid) [Pseudomonas aeruginosa PAO1]
5U2G_A	7.87e-55	24	733	7	775	2.6Angstrom Resolution Crystal Structure of Penicillin-Binding Protein 1A from Haemophilus influenzae [Haemophilus influenzae Rd KW20],5U2G_B 2.6 Angstrom Resolution Crystal Structure of Penicillin-Binding Protein 1A from Haemophilus influenzae [Haemophilus influenzae Rd KW20]
7U4H_A	1.50e-44	54	711	35	753	ChainA, Penicillin-binding protein 1A (Pbp1a) [Chlamydia trachomatis D/UW-3/CX],7U4H_B Chain B, Penicillin-binding protein 1A (Pbp1a) [Chlamydia trachomatis D/UW-3/CX]
5FGZ_A	1.65e-42	15	730	116	705	E.coli PBP1b in complex with FPI-1465 [Escherichia coli K-12],5HL9_A E. coli PBP1b in complex with acyl-ampicillin and moenomycin [Escherichia coli K-12],5HLA_A E. coli PBP1b in complex with acyl-cephalexin and moenomycin [Escherichia coli K-12],5HLB_A E. coli PBP1b in complex with acyl-aztreonam and moenomycin [Escherichia coli K-12],5HLD_A E. coli PBP1b in complex with acyl-CENTA and moenomycin [Escherichia coli K-12],6YN0_A Structure of E. coli PBP1b with a FtsN peptide activating transglycosylase activity [Escherichia coli K-12],7LQ6_A Chain A, Penicillin-binding protein 1B [Escherichia coli K-12]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
O66874	1.20e-80	24	734	30	679	Penicillin-binding protein 1A OS=Aquifex aeolicus (strain VF5) OX=224324 GN=mrcA PE=1 SV=1
Q9KNU5	1.85e-76	11	740	25	775	Penicillin-binding protein 1A OS=Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) OX=243277 GN=mrcA PE=3 SV=2
O87579	2.61e-72	24	737	35	720	Penicillin-binding protein 1A OS=Neisseria lactamica OX=486 GN=mrcA PE=3 SV=1
P0A0Z6	1.70e-70	15	716	29	703	Penicillin-binding protein 1A OS=Neisseria meningitidis serogroup B (strain MC58) OX=122586 GN=mrcA PE=3 SV=1
P0A0Z5	1.70e-70	15	716	29	703	Penicillin-binding protein 1A OS=Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491) OX=122587 GN=mrcA PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.873643	0.124290	0.001596	0.000121	0.000107	0.000254

TMHMM  Annotations     

There is no transmembrane helices in MGYG000004878_02593.