| Basic Information | |
|---|---|
| Species | Cucumis sativus |
| Cazyme ID | Cucsa.149140.1 |
| Family | GT68 |
| Protein Properties | Length: 574 Molecular Weight: 65445.6 Isoelectric Point: 6.6227 |
| Chromosome | Chromosome/Scaffold: 01110 Start: 9671 End: 12377 |
| Description | O-fucosyltransferase family protein |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GT68 | 254 | 548 | 0 |
| NRVLVIPSHKVDYQFSRVIDIDRMNMCLGRKVVISFEEFSEIKKHHLHIDRFICYFSKPNPCYVDDEHISKLKNLGISMGKLESAWNEDTKHPNRKTVSD VESKFSSNNDDVIAVGDIFFANVEQEWVNQPGGPIAHKCQTLIEPSHLIKLTAQRFIQTFLGKNYIALHFRRHGFLKFCNAKQPSCFYPIPQAADCIIRM VERANVPVIYLSTDAAESEHGLLQSLLVLNGKPIPLVKRPPRNSAEKWDALLYRHGLEEDSQVEAMLDKTICAMSSTFIGAPGSTFTEDILRLRK | |||
| Full Sequence |
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| Protein Sequence Length: 574 Download |
| MDRSDSSSDE EDDRQSLVEH NDIKPHPSPP THSTTFDIDD DPHFRPPIPR FPFSIPKFAF 60 DKRYYYLLAA ALPLCILVLF FSVDITSLFS TTLSSTLKTS DSLTDRMRES ELTALYLLRQ 120 QQLGFFHLWN HSLFLQSNSS FNSTPSNNLS SNSALTEYIK SALLKQITLN KEIQNVLLSP 180 HRSGNLSEEV GDALPMDTFA LDRCRKMDQK LSDRRTIEWK PKSNKFLFAI CTSGQMSNHL 240 ICLEKHMFFA AILNRVLVIP SHKVDYQFSR VIDIDRMNMC LGRKVVISFE EFSEIKKHHL 300 HIDRFICYFS KPNPCYVDDE HISKLKNLGI SMGKLESAWN EDTKHPNRKT VSDVESKFSS 360 NNDDVIAVGD IFFANVEQEW VNQPGGPIAH KCQTLIEPSH LIKLTAQRFI QTFLGKNYIA 420 LHFRRHGFLK FCNAKQPSCF YPIPQAADCI IRMVERANVP VIYLSTDAAE SEHGLLQSLL 480 VLNGKPIPLV KRPPRNSAEK WDALLYRHGL EEDSQVEAML DKTICAMSST FIGAPGSTFT 540 EDILRLRKDW GTASMCDEYL CQGEEPNFIS ENE* |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| cd11296 | O-FucT_like | 6.0e-5 | 226 | 267 | 42 | + GDP-fucose protein O-fucosyltransferase and related proteins. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes. | ||
| pfam10250 | O-FucT | 4.0e-5 | 249 | 540 | 327 | + GDP-fucose protein O-fucosyltransferase. This is a family of conserved proteins representing the enzyme responsible for adding O-fucose to EGF (epidermal growth factor-like) repeats. Six highly conserved cysteines are present in O-FucT-1 as well as a DXD-like motif (ERD), conserved in mammals, Drosophila, and C. elegans. Both features are characteristic of several glycosyltransferase families. The enzyme is a membrane-bound protein released by proteolysis and, as for most glycosyltransferases, is strongly activated by manganese. | ||
| cd11298 | O-FucT-2 | 4.0e-9 | 414 | 540 | 129 | + GDP-fucose protein O-fucosyltransferase 2. O-FucT-2 adds O-fucose to thrombospondin type 1 repeats (TSRs), and appears conserved in bilateria. The O-fucosylation of TSRs appears to play a role in regulating secretion of metalloproteases of the ADAMTS superfamily. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes. | ||
| cd11296 | O-FucT_like | 9.0e-19 | 389 | 547 | 169 | + GDP-fucose protein O-fucosyltransferase and related proteins. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes. | ||
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | AAM66093.1 | 0 | 6 | 573 | 4 | 566 | unknown [Arabidopsis thaliana] |
| RefSeq | NP_173170.2 | 0 | 6 | 573 | 4 | 564 | unknown protein [Arabidopsis thaliana] |
| RefSeq | NP_199853.1 | 0 | 6 | 573 | 4 | 566 | unknown protein [Arabidopsis thaliana] |
| RefSeq | XP_002264087.1 | 0 | 7 | 573 | 5 | 559 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002303337.1 | 0 | 84 | 573 | 51 | 527 | predicted protein [Populus trichocarpa] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 4ap6_D | 0.005 | 414 | 540 | 277 | 383 | A Chain A, Crystal Structure Of Human Pofut2 E54a Mutant In Complex With Gdp- Fucose |
| PDB | 4ap6_C | 0.005 | 414 | 540 | 277 | 383 | A Chain A, Crystal Structure Of Human Pofut2 E54a Mutant In Complex With Gdp- Fucose |
| PDB | 4ap6_B | 0.005 | 414 | 540 | 277 | 383 | A Chain A, Crystal Structure Of Human Pofut2 E54a Mutant In Complex With Gdp- Fucose |
| PDB | 4ap6_A | 0.005 | 414 | 540 | 277 | 383 | A Chain A, Crystal Structure Of Human Pofut2 E54a Mutant In Complex With Gdp- Fucose |
| PDB | 4ap5_B | 0.005 | 414 | 540 | 263 | 369 | A Chain A, Crystal Structure Of Human Pofut2 |
