| Basic Information | |
|---|---|
| Species | Physcomitrella patens |
| Cazyme ID | Pp1s149_19V6.1 |
| Family | GT68 |
| Protein Properties | Length: 466 Molecular Weight: 52628.5 Isoelectric Point: 8.2217 |
| Chromosome | Chromosome/Scaffold: 149 Start: 78024 End: 79421 |
| Description | O-fucosyltransferase family protein |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| Plaza |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GT68 | 159 | 442 | 0 |
| LVLPHGKLDYKYEHLLDMAHLKKCLGNSSVITFEEFAELRNETLHVDRLICYMHSCHFDKDHPRAWEALGYTFGERQDAWSSSSNPPAAHKDDILSRFAC NAKVLAVGDLFYAAVEDSHGFAVAHDCTVSPVLPNRNIVVTAERFVQTYLGPNFLSLHFRRHGFLVFCNKQKSPSCFYPIPQAARCIRRKVWEARADVVY LSTDAPASEVDILKQELAGVTVVRRTKVHEAEAKWDSLLWRNGLESELAVMAMVDKTICVLGVGFMGTRESTFSYDILRMRNEM | |||
| Full Sequence |
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| Protein Sequence Length: 466 Download |
| MERRDWIVLL PSLALALVFL ISSSITHWTW QSRWDKESSR VATSSKAMAV LNRQEVELLA 60 ELNNPLSSIT NTKFAKQQLT VNKELQSLLM QSHGNASEKA ILAACARKRR GAELSGEGIQ 120 WRPKADRYLL MICQTGQVTN HLICFRKHMW FAALLNRTLV LPHGKLDYKY EHLLDMAHLK 180 KCLGNSSVIT FEEFAELRNE TLHVDRLICY MHSCHFDKDH PRAWEALGYT FGERQDAWSS 240 SSNPPAAHKD DILSRFACNA KVLAVGDLFY AAVEDSHGFA VAHDCTVSPV LPNRNIVVTA 300 ERFVQTYLGP NFLSLHFRRH GFLVFCNKQK SPSCFYPIPQ AARCIRRKVW EARADVVYLS 360 TDAPASEVDI LKQELAGVTV VRRTKVHEAE AKWDSLLWRN GLESELAVMA MVDKTICVLG 420 VGFMGTREST FSYDILRMRN EMRTASSCDG FICDGETPSF LAQAP* |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| cd11302 | O-FucT-1 | 0.005 | 151 | 383 | 296 | + GDP-fucose protein O-fucosyltransferase 1. The protein O-fucosyltransferase 1 (Ofut1 or O-FucT-1) adds O-fucose to EGF (epidermal growth factor-like) repeats. The O-fucsosylation of the Notch receptor signaling protein is dependent on this enzyme, which requires GDP-fucose as a substrate. O-fucose residues added to the target of O-FucT-1 may be further elongated by other glycosyltransferases. On top of O-fucosylation, O-FucT-1 may have other functions such as the regulation of the Notch receptor exit from the ER. Six highly conserved cysteines are present in O-FucT-1, which is a soluble ER protein, as well as a DXD-like motif (ERD), conserved in mammals, Drosophila, and C. elegans. Both features are characteristic of several glycosyltransferase families. The membrane-bound pre-protein is released by proteolysis and, as for most glycosyltransferases, is strongly activated by manganese. O-FucT-1 is similar to family 1 glycosyltransferases (GT1). | ||
| cd11296 | O-FucT_like | 0.0007 | 128 | 162 | 35 | + GDP-fucose protein O-fucosyltransferase and related proteins. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes. | ||
| pfam10250 | O-FucT | 4.0e-10 | 151 | 439 | 324 | + GDP-fucose protein O-fucosyltransferase. This is a family of conserved proteins representing the enzyme responsible for adding O-fucose to EGF (epidermal growth factor-like) repeats. Six highly conserved cysteines are present in O-FucT-1 as well as a DXD-like motif (ERD), conserved in mammals, Drosophila, and C. elegans. Both features are characteristic of several glycosyltransferase families. The enzyme is a membrane-bound protein released by proteolysis and, as for most glycosyltransferases, is strongly activated by manganese. | ||
| cd11298 | O-FucT-2 | 2.0e-10 | 266 | 435 | 202 | + GDP-fucose protein O-fucosyltransferase 2. O-FucT-2 adds O-fucose to thrombospondin type 1 repeats (TSRs), and appears conserved in bilateria. The O-fucosylation of TSRs appears to play a role in regulating secretion of metalloproteases of the ADAMTS superfamily. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes. | ||
| cd11296 | O-FucT_like | 3.0e-14 | 292 | 440 | 160 | + GDP-fucose protein O-fucosyltransferase and related proteins. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes. | ||
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| RefSeq | NP_001060060.1 | 0 | 78 | 463 | 153 | 555 | Os07g0572600 [Oryza sativa (japonica cultivar-group)] |
| RefSeq | NP_173170.2 | 0 | 12 | 463 | 78 | 562 | unknown protein [Arabidopsis thaliana] |
| RefSeq | XP_001772368.1 | 0 | 131 | 465 | 1 | 335 | predicted protein [Physcomitrella patens subsp. patens] |
| RefSeq | XP_002264087.1 | 0 | 77 | 462 | 150 | 556 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002533327.1 | 0 | 77 | 463 | 160 | 563 | conserved hypothetical protein [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 4ap5_B | 0.000005 | 308 | 440 | 263 | 377 | A Chain A, Crystal Structure Of Human Pofut2 |
| PDB | 4ap5_A | 0.000005 | 308 | 440 | 263 | 377 | A Chain A, Crystal Structure Of Human Pofut2 |
| PDB | 4ap6_D | 0.000005 | 308 | 440 | 277 | 391 | A Chain A, Crystal Structure Of Human Pofut2 E54a Mutant In Complex With Gdp- Fucose |
| PDB | 4ap6_C | 0.000005 | 308 | 440 | 277 | 391 | A Chain A, Crystal Structure Of Human Pofut2 E54a Mutant In Complex With Gdp- Fucose |
| PDB | 4ap6_B | 0.000005 | 308 | 440 | 277 | 391 | A Chain A, Crystal Structure Of Human Pofut2 E54a Mutant In Complex With Gdp- Fucose |
