| Basic Information | |
|---|---|
| Species | Physcomitrella patens |
| Cazyme ID | Pp1s111_147V6.1 |
| Family | GT47 |
| Protein Properties | Length: 434 Molecular Weight: 49010.5 Isoelectric Point: 9.2753 |
| Chromosome | Chromosome/Scaffold: 111 Start: 913114 End: 915584 |
| Description | Exostosin family protein |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| Plaza |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GT47 | 151 | 360 | 2.6e-29 |
| LSRLPYWNHGLNHVVISVVDKPRNPDARSIEMASTMTSITHQTIYRAGFDVSVPLPQRKFYPNLQRLSAMGRKYLLTYKGNRCLEVGSRGGRVCIDPVLR GMHNGKDIVVVTTCKQVSSNEVAKVEARCAKDQFVYDQYKFDDLINSTFALVPAGSGVSSYRLMEVLSAGSIPVAISESIVLPFDSLIEWRRCLFVFPPS QMHRIVPTLQ | |||
| Full Sequence |
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| Protein Sequence Length: 434 Download |
| MSTIKEAPGP RLSPYLQCFY GLFNLLFLCV MILSFLSVSG TFSRSPEAQT SNLTTISRSS 60 LLHTNIVPTQ GSSTSARSVI DTISSCSMDN CFNYSRCDKM EELLVYHYDS QYSPDWYFKD 120 ALKRSPYYTT NPAEACLFLV VDRRRVGGPP LSRLPYWNHG LNHVVISVVD KPRNPDARSI 180 EMASTMTSIT HQTIYRAGFD VSVPLPQRKF YPNLQRLSAM GRKYLLTYKG NRCLEVGSRG 240 GRVCIDPVLR GMHNGKDIVV VTTCKQVSSN EVAKVEARCA KDQFVYDQYK FDDLINSTFA 300 LVPAGSGVSS YRLMEVLSAG SIPVAISESI VLPFDSLIEW RRCLFVFPPS QMHRIVPTLQ 360 TLNKDEIEFR REHCLFIYRQ FFGSDDKVVA TTAMAFKSRF FGVLPKLIPN VPLPPRHLSL 420 KQQQQQQPNL KLQ* |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03016 | Exostosin | 1.0e-28 | 110 | 360 | 278 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| RefSeq | XP_001761179.1 | 0 | 86 | 407 | 11 | 343 | predicted protein [Physcomitrella patens subsp. patens] |
| RefSeq | XP_001764506.1 | 0 | 1 | 422 | 1 | 432 | predicted protein [Physcomitrella patens subsp. patens] |
| RefSeq | XP_001764615.1 | 0 | 1 | 426 | 1 | 427 | predicted protein [Physcomitrella patens subsp. patens] |
| RefSeq | XP_001769183.1 | 0 | 1 | 433 | 1 | 433 | predicted protein [Physcomitrella patens subsp. patens] |
| RefSeq | XP_001769488.1 | 0 | 86 | 405 | 11 | 335 | predicted protein [Physcomitrella patens subsp. patens] |
| Transmembrane Domains | |||||
|---|---|---|---|---|---|
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| Start | End | ||||
| 20 | 42 | ||||
| Hydropathy |
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| EST Download unfiltered results here | ||||
|---|---|---|---|---|
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| Hit | Length | Start | End | EValue |
| FC327742 | 265 | 1 | 265 | 0 |
| DC945220 | 194 | 241 | 434 | 0 |
| BJ611124 | 181 | 254 | 434 | 0 |
| FC327741 | 126 | 309 | 434 | 0 |
| FC387632 | 186 | 91 | 272 | 0 |
| Orthologous Group | |||||
|---|---|---|---|---|---|
| Species | ID | ||||
| Physcomitrella patens | Pp1s143_125V6.1 | Pp1s115_92V6.1 | Pp1s47_67V6.1 | Pp1s13_257V6.1 | Pp1s47_134V6.1 |
| Pp1s47_145V6.1 | Pp1s69_76V6.1 | Pp1s68_175V6.1 | |||
| Selaginella moellendorffii | 23945 | ||||
| Sequence Alignments (This image is cropped. Click for full image.) |
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| Phylogeny |
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