| Basic Information | |
|---|---|
| Species | Physcomitrella patens |
| Cazyme ID | Pp1s69_76V6.1 |
| Family | GT47 |
| Protein Properties | Length: 430 Molecular Weight: 49029.2 Isoelectric Point: 7.5393 |
| Chromosome | Chromosome/Scaffold: 69 Start: 457059 End: 459170 |
| Description | Exostosin family protein |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| Plaza |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GT47 | 55 | 362 | 3.9e-39 |
| PPVYLHPARFDTSMRKVEENRNPTESSHCSMGSCFDYSRCDGMEELLVYHYDSPSSQAWYFKQALEKSPYYTVDPSKACLFFVTVDTRAEHALDFNTLPY WNHGLNHVIISVSDNWAKQKTLIPDVAEMASTMTSSTHRTTYREGFDISVPLPQRKFYLELQRRKALERKYFLTFTGTRFLGRSGLRNNAVLRSMHNGEN IIVATTCNQGLNSEAMLKHPELRSDCARDQSIYDKYKFEDLMDSTFGLVSAGRGSSSFRLLEVLSAGSIPVVISDNFVLPFDTLIDWSRCLYVFPSSQMH RIVRTLRS | |||
| Full Sequence |
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| Protein Sequence Length: 430 Download |
| MSTIKEAPEP KISTYLQILY GLFNFLLLGL MIVSVVNMGT YVISGGGPTS NATSPPVYLH 60 PARFDTSMRK VEENRNPTES SHCSMGSCFD YSRCDGMEEL LVYHYDSPSS QAWYFKQALE 120 KSPYYTVDPS KACLFFVTVD TRAEHALDFN TLPYWNHGLN HVIISVSDNW AKQKTLIPDV 180 AEMASTMTSS THRTTYREGF DISVPLPQRK FYLELQRRKA LERKYFLTFT GTRFLGRSGL 240 RNNAVLRSMH NGENIIVATT CNQGLNSEAM LKHPELRSDC ARDQSIYDKY KFEDLMDSTF 300 GLVSAGRGSS SFRLLEVLSA GSIPVVISDN FVLPFDTLID WSRCLYVFPS SQMHRIVRTL 360 RSLREEDIEF RWSYCLFIYR EFLADDDKIV KTVAMALKAR FFGALPKLNP NIPLLPRHLT 420 MEYAMSEFL* |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03016 | Exostosin | 3.0e-33 | 104 | 362 | 283 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| RefSeq | XP_001761172.1 | 0 | 77 | 408 | 5 | 343 | predicted protein [Physcomitrella patens subsp. patens] |
| RefSeq | XP_001764506.1 | 0 | 1 | 423 | 1 | 432 | predicted protein [Physcomitrella patens subsp. patens] |
| RefSeq | XP_001764615.1 | 0 | 1 | 429 | 1 | 429 | predicted protein [Physcomitrella patens subsp. patens] |
| RefSeq | XP_001769183.1 | 0 | 1 | 422 | 1 | 421 | predicted protein [Physcomitrella patens subsp. patens] |
| RefSeq | XP_001769488.1 | 0 | 77 | 406 | 5 | 335 | predicted protein [Physcomitrella patens subsp. patens] |
| Transmembrane Domains | |||||
|---|---|---|---|---|---|
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| Start | End | ||||
| 21 | 43 | ||||
| Hydropathy |
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| EST Download unfiltered results here | ||||
|---|---|---|---|---|
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| Hit | Length | Start | End | EValue |
| FC387632 | 191 | 88 | 278 | 0 |
| FC393957 | 207 | 1 | 207 | 0 |
| FC425748 | 154 | 277 | 430 | 0 |
| DC924657 | 148 | 283 | 430 | 0 |
| FC393956 | 143 | 288 | 430 | 0 |
| Orthologous Group | |||||
|---|---|---|---|---|---|
| Species | ID | ||||
| Physcomitrella patens | Pp1s143_125V6.1 | Pp1s115_92V6.1 | Pp1s47_67V6.1 | Pp1s13_257V6.1 | Pp1s47_134V6.1 |
| Pp1s47_145V6.1 | Pp1s68_175V6.1 | Pp1s111_147V6.1 | |||
| Selaginella moellendorffii | 23945 | ||||
| Sequence Alignments (This image is cropped. Click for full image.) |
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| Phylogeny |
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