| AD families | AD genes | Defense system | CLAN ID | Phages/MGEs | References | Description |
|---|---|---|---|---|---|---|
| APIS091 | HOS17_gp01 | restriction-modification (RM);bacteriophage exclusion (BREX) | CLAN035 | T3 of E. coli | Andriianov et al., 2023 | T3 encodes a SAMase that circumvents the SAM-dependent Type I R-M defence of the host E. coli through cleavage of S-adenosyl-methionine (SAM). SAMase also allows T3 to evade BREX defence. |
| APIS093 | CLAN035 | Pantoea phage vB_PagP-SK1 |