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Seed proteins  | Seed genomic context  | Seed protein 3D structures  |  Structural homologs  |  Family infomation  | Homology to other families  | Family members, sources, and their hosts  

Seed protein information help

APIS family ID APIS015
Inhibited defense system restriction-modification (RM)
CLAN ID CLAN014
Seed protein property
Accession ID Gene name Protein length Molecular weight Isoelectric point Charge
NP_049734.1 gene_page: IpII 100 11085.80 10.0101 5.0
Phage property
Phage Assembly id
T4 of E. coli GCF_000836945.1
PMID/References Silas et al., 2023
PDB structures ;
Pfam domains
Phrog phrog_7857
Host taxa d__Bacteria;p__Proteobacteria;c__Gammaproteobacteria;o__Enterobacterales;f__Enterobacteriaceae;g__Escherichia;s__Escherichia coli
Gene Location Start: 65416;  End: 65718;  Strand: -
Description T4 internal-protein, a T2-restricting defense system was disabled by IpII. IpII restored T2 and T6 plaquing but did not further enhance T4 infection.

Seed genomic context      Download table help

Genome accession Start End Strand Protein ID Length Molecular weight Charge Isoelectric point Function Phrog PFAM
NC_000866.4 63381 63557 - NP_049729.1 58 6611.00 2.0 10.3162 hypothetical protein phrog_1986
NC_000866.4 63557 63919 - NP_049730.1 120 13813.65 -1.5 5.9896 autonomous glycyl radical cofactor GrcA phrog_21327 ; phrog_1209 ; phrog_32552 PF01228.24
NC_000866.4 63927 64256 - NP_049731.1 109 12835.07 4.5 9.3432 hypothetical protein phrog_29719 ; phrog_2049 ; phrog_11888
NC_000866.4 64253 64912 - NP_049732.1 219 25026.71 12.5 9.4437 hypothetical protein phrog_1488
NC_000866.4 64939 65355 - NP_049733.1 138 16078.57 7.0 9.7612 endonuclease V N-glycosylase UV repair enzyme phrog_1183 ; phrog_18345 PF03013.17
NC_000866.4 65416 65718 - NP_049734.1 100 11085.80 5.0 10.0101 internal virion protein phrog_8765 ; phrog_3155 ; phrog_2667 ; phrog_7857 ; phrog_15565 ; phrog_5341 ; phrog_8111
NC_000866.4 65834 66415 - NP_049735.1 193 21686.75 10.0 10.1965 internal virion protein phrog_8765 ; phrog_2667 ; phrog_15565 ; phrog_5341 ; phrog_35655 ; phrog_8111
NC_000866.4 66503 66997 - NP_049736.1 164 18691.56 8.5 10.0791 glycoside hydrolase family protein phrog_15410 ; phrog_7 ; phrog_33534 ; phrog_13211 PF00959.22
NC_000866.4 67035 67490 - NP_049737.1 151 17653.27 -3.0 5.0111 nudix hydrolase phrog_9999 ; phrog_1198 ; phrog_1185 PF00293.31
NC_000866.4 67652 67960 - NP_049738.1 102 12155.99 0.0 6.2859 hypothetical protein phrog_35263 ; phrog_2203
NC_000866.4 67957 68319 - NP_049739.1 120 14154.75 4.5 8.9827 hypothetical protein phrog_2330

Seed genomic context- JBrowse     

Predicted 3D structure by alphafold2 with pTM = 0.57 Download help

pTM is for the estimate of the TM-score, which is obtained from a pairwise error prediction. The higher pTM score indicates better model quality.

pLDDT is for per-residue accuracy of the structure, which representes the quality of the residue. A higher value indicates better prediction accuracy. More detail please see AlphaFold .

Residues were colored according to plddt ( blue-> high quality; red-> low quality ).

Full Sequence
90 < plddt <=100 ;
70 < plddt <= 90 ;
50 < plddt <= 70 ;
0 <= plddt <= 50 ;      Download help

Structural homologs

No homologs found in AlphaFold database

No homologs found in esmfold database

Family information      Download help

Fam ID Seed protein Member count Model Alignment
APIS015 NP_049734.1 34 HMM model Member alignment

Host Taxa distribution

Length distribution

Homology to other families       help

Clan ID: CLAN014

APIS015 has no similar APIS family.

Family members, sources, and their hosts        help

Results of representative protein blast against members.

Member pident evalue bitscore qcovs phage host SourceDB Pfam Phrog
AP019521_00117 93.000 2.62e-60 187 100% Escherichia phage KIT01 Escherichia INPHARED phrog_7857 phrog_2667
HE956709_00130 52.222 1.55e-22 92.0 90% Yersinia phage phiR1-RT Yersinia INPHARED phrog_7857
IMGVR_UViG_3300045988_040361|3300045988|Ga0495776_001689_155076_155378 93.023 1.33e-51 165 86% IMGVR phrog_7857
KP202158_00128 51.111 1.36e-21 89.4 90% Yersinia phage vB_YenM_TG1 Yersinia INPHARED phrog_7857
KR269720_00074 93.000 6.51e-61 189 100% Klebsiella phage PKO111 Klebsiella INPHARED phrog_7857
KU878969_00113 94.000 1.45e-61 191 100% Escherichia phage MX01 Escherichia INPHARED phrog_7857
KY593455_00133 62.245 6.46e-34 120 98% Yersinia phage fHe-Yen9-01 Yersinia INPHARED phrog_8765 phrog_7857
MGV-GENOME-0377468_124 94.186 1.65e-52 167 86% MGV phrog_7857
MGV-GENOME-0377499_216 92.000 9.06e-60 186 100% MGV phrog_7857
MGV-GENOME-0377588_265 93.000 1.45e-60 188 100% MGV phrog_7857
MGV-GENOME-0377667_253 93.023 1.37e-51 165 86% MGV phrog_7857
MH051917_00166 93.000 1.50e-60 188 100% Enterobacteria phage vB_EcoM_IME341 Enterobacteria INPHARED phrog_7857
MK234886_00064 92.000 1.06e-59 186 100% Escherichia phage AnYang Escherichia INPHARED phrog_7857 phrog_2667
MK295203_00123 93.000 2.28e-60 187 100% Escherichia phage vB_EcoM_005 Escherichia INPHARED phrog_7857 phrog_2667
MN013081_00019 82.558 1.42e-44 147 86% Klebsiella phage vB_KpnM_Potts1 Klebsiella INPHARED phrog_7857
MN044033_00110 93.182 4.64e-54 172 88% Klebsiella phage Marfa Klebsiella INPHARED phrog_7857
MN106245_00120 94.186 2.62e-52 167 86% Klebsiella phage EI Klebsiella INPHARED phrog_7857
MN434095_00109 95.349 7.23e-54 171 86% Klebsiella phage JIPh_Kp122 Klebsiella INPHARED phrog_7857
MT446423_00066 92.000 8.59e-60 186 100% Escherichia virus TH58 Escherichia INPHARED phrog_7857
MW239157_00163 94.000 8.64e-62 191 100% Klebsiella phage vB_KpnM_17-11 Klebsiella INPHARED phrog_7857
MW325771_00143 77.551 4.71e-36 126 98% Salmonella phage KM16 Salmonella INPHARED phrog_7857
MZ375356_00098 100.000 9.39e-62 191 94% Escherichia phage T4 Escherichia INPHARED phrog_7857
MZ560701_00153 91.000 1.76e-58 182 100% Escherichia phage vB_EcoM_TU01 Escherichia INPHARED phrog_7857
MZ634347_00193 94.186 3.09e-52 167 86% Klebsiella phage PWKp16 Klebsiella INPHARED phrog_7857
NP_049734.1 100.000 4.29e-72 200 100% T4 of E. coli Escherichia coli NCBI phrog_7857
OK254198_00028 94.186 6.15e-53 169 86% Escherichia phage PSD2001 Escherichia INPHARED phrog_7857
OL770074_00008 93.000 1.40e-60 188 100% Escherichia phage vB_EcoM-RPN187 Escherichia INPHARED phrog_7857
OL870318_00109 92.000 8.78e-60 186 100% Klebsiella phage UTI-K1 Klebsiella INPHARED phrog_7857
OL964735_00119 100.000 1.08e-65 201 100% Escherichia phage T4 Escherichia INPHARED phrog_7857
OP172784_00207 91.000 5.07e-60 187 100% Escherichia phage ECO07P1 Escherichia INPHARED phrog_7857
OQ331036_00272 58.511 1.05e-29 110 94% Yersinia phage MHG19 Yersinia INPHARED phrog_7857
OQ721911_00120 94.000 4.53e-61 189 100% Escherichia phage vB_VIPECOOM03 Escherichia INPHARED phrog_7857
OV877765_00121 93.000 9.46e-61 188 100% Escherichia phage UGJNEcP4 Escherichia INPHARED phrog_7857 phrog_2667
uvig_234713_124 94.186 1.60e-52 167 86% GPD phrog_7857
APIS Contig Range
APIS015 NC_000866.4 63381 - 68319

Gene cluster comparison plot by clinker      Download html