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Cite: NAR/gkaa742 2020



PUL General Information

Literature Information

PUL ID

PUL0472

PubMed

18996345, Cell Host Microbe. 2008 Nov 13;4(5):447-57. doi: 10.1016/j.chom.2008.09.007.

Characterization method

microarray,qPCR

Genomic accession number

AE015928.1

Nucelotide position range

5301977-5353000

Substrate

mucin

Loci

BT4069-BT4096

Species

Bacteroides thetaiotaomicron/818

Degradation or Biosynthesis

degradation

Gene Name

Locus Tag

Protein ID

Gene Position

GenBank Contig Range

EC Number

- BT_4069 AAO79174.1 0 - 1605 (+) AE015928.1:5301977-5303582 -
- BT_4070 AAO79175.1 1795 - 2320 (+) AE015928.1:5303772-5304297 -
- BT_4071 AAO79176.1 2395 - 2626 (+) AE015928.1:5304372-5304603 -
- BT_4072 AAO79177.1 2633 - 5183 (+) AE015928.1:5304610-5307160 -
- BT_4073 AAO79178.1 5217 - 7566 (+) AE015928.1:5307194-5309543 -
- BT_4074 AAO79179.1 7579 - 10663 (+) AE015928.1:5309556-5312640 -
- BT_4075 AAO79180.1 11428 - 12832 (+) AE015928.1:5313405-5314809 -
- BT_4076 AAO79181.1 12902 - 15581 (+) AE015928.1:5314879-5317558 -
- BT_4077 AAO79182.1 15590 - 16457 (+) AE015928.1:5317567-5318434 -
- BT_4078 AAO79183.1 16788 - 17481 (+) AE015928.1:5318765-5319458 -
- BT_4079 AAO79184.1 17508 - 19269 (+) AE015928.1:5319485-5321246 -
- BT_4080 AAO79185.1 19453 - 20824 (+) AE015928.1:5321430-5322801 -
- BT_4081 AAO79186.1 20855 - 23957 (+) AE015928.1:5322832-5325934 -
- BT_4082 AAO79187.1 23988 - 26040 (+) AE015928.1:5325965-5328017 -
- BT_4083 AAO79188.1 26059 - 27088 (+) AE015928.1:5328036-5329065 -
- BT_4084 AAO79189.1 27114 - 28446 (+) AE015928.1:5329091-5330423 -
- BT_4085 AAO79190.1 28663 - 30520 (+) AE015928.1:5330640-5332497 -
- BT_4086 AAO79191.1 30549 - 31002 (+) AE015928.1:5332526-5332979 -
- BT_4087 AAO79192.1 31019 - 32072 (+) AE015928.1:5332996-5334049 -
- BT_4088 AAO79193.1 32096 - 35231 (+) AE015928.1:5334073-5337208 -
- BT_4089 AAO79194.1 35237 - 37034 (+) AE015928.1:5337214-5339011 -
- BT_4090 AAO79195.1 37038 - 40119 (+) AE015928.1:5339015-5342096 -
- BT_4091 AAO79196.1 40271 - 42260 (+) AE015928.1:5342248-5344237 -
- BT_4092 AAO79197.1 42297 - 44571 (+) AE015928.1:5344274-5346548 -
- BT_4093 AAO79198.1 44689 - 46843 (+) AE015928.1:5346666-5348820 -
- BT_4094 AAO79199.1 46869 - 48003 (+) AE015928.1:5348846-5349980 -
- BT_4095 AAO79200.1 48009 - 49548 (+) AE015928.1:5349986-5351525 -
- BT_4096 AAO79201.1 49641 - 51024 (+) AE015928.1:5351618-5353001 -

Cluster number

1

Gene name

Gene position

Gene type

Found by CGCFinder?

- 1 - 1605 (+) CDS No
- 1796 - 2320 (+) TF: DBD-Pfam|GerE No
- 2396 - 2626 (+) CDS No
- 2634 - 5183 (+) CAZyme: GH38 Yes
- 5218 - 7566 (+) CAZyme: GH92 Yes
- 7580 - 10663 (+) CAZyme: CBM32|GH2 Yes
- 11429 - 12832 (+) other Yes
- 12903 - 15581 (+) CAZyme: GH78|CBM67 Yes
- 15591 - 16457 (+) CAZyme: CE1 Yes
- 16789 - 17481 (+) other Yes
- 17509 - 19269 (+) other Yes
- 19454 - 20824 (+) other Yes
- 20856 - 23957 (+) TC: gnl|TC-DB|Q45780|1.B.14.6.1 Yes
- 23989 - 26040 (+) other Yes
- 26060 - 27088 (+) other Yes
- 27115 - 28446 (+) other Yes
- 28664 - 30520 (+) other Yes
- 30550 - 31002 (+) other Yes
- 31020 - 32072 (+) other Yes
- 32097 - 35231 (+) other Yes
- 35238 - 37034 (+) other Yes
- 37039 - 40119 (+) TC: gnl|TC-DB|Q45780|1.B.14.6.1 Yes
- 40272 - 42260 (+) other Yes
- 42298 - 44571 (+) CAZyme: GH92 Yes
- 44690 - 46843 (+) CAZyme: GH92 Yes
- 46870 - 48003 (+) CAZyme: GH130 Yes
- 48010 - 49548 (+) CAZyme: GH43_8 Yes
- 49642 - 51024 (+) CDS No

PUL ID

PUL0472

PubMed

18996345, Cell Host Microbe. 2008 Nov 13;4(5):447-57. doi: 10.1016/j.chom.2008.09.007.

Title

Mucosal glycan foraging enhances fitness and transmission of a saccharolytic human gut bacterial symbiont.

Author

Martens EC, Chiang HC, Gordon JI

Abstract

The distal human gut is a microbial bioreactor that digests complex carbohydrates. The strategies evolved by gut microbes to sense and process diverse glycans have important implications for the assembly and operation of this ecosystem. The human gut-derived bacterium Bacteroides thetaiotaomicron forages on both host and dietary glycans. Its ability to target these substrates resides in 88 polysaccharide utilization loci (PULs), encompassing 18% of its genome. Whole genome transcriptional profiling and genetic tests were used to define the mechanisms underlying host glycan foraging in vivo and in vitro. PULs that target all major classes of host glycans were identified. However, mucin O-glycans are the principal host substrate foraged in vivo. Simultaneous deletion of five genes encoding ECF-sigma transcription factors, which activate mucin O-glycan utilization, produces defects in bacterial persistence in the gut and in mother-to-offspring transmission. Thus, PUL-mediated glycan catabolism is an important component in gut colonization and may impact microbiota ecology.