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Browse anti-prokaryotic immune system families by CLAN ID

AD families AD genes Defense system CLAN ID Phages/MGEs References Description
APIS002 vs.4 cyclic oligonucleotide-based antiphage signaling system (CBASS) CLAN018 T4 of E. coli PMID:36848932 Vs.4 antagonized cGAS signaling by binding tightly to cGAMP (dissociation constant of approximately 30 nM) and sequestering it; Bioinformatic analyses identified 198 homologues of Vs.4 in diverse phages; belongs to PHROG 717.
APIS004 Acb2 cyclic oligonucleotide-based antiphage signaling system (CBASS) CLAN018 PaMx33 of Pseudomonas aeruginosa PMID:36750095 Anti-CBASS protein ("Acb2") that forms a hexamer with three 3',3'-cGAMP molecules and reduces phospholipase activity.
APIS048 CLAN018 Ralstonia phage YO108_2