| AD families | AD genes | Defense system | CLAN ID | Phages/MGEs | References | Description |
|---|---|---|---|---|---|---|
| APIS002 | vs.4 | cyclic oligonucleotide-based antiphage signaling system (CBASS) | CLAN018 | T4 of E. coli | PMID:36848932 | Vs.4 antagonized cGAS signaling by binding tightly to cGAMP (dissociation constant of approximately 30 nM) and sequestering it; Bioinformatic analyses identified 198 homologues of Vs.4 in diverse phages; belongs to PHROG 717. |
| APIS004 | Acb2 | cyclic oligonucleotide-based antiphage signaling system (CBASS) | CLAN018 | PaMx33 of Pseudomonas aeruginosa | PMID:36750095 | Anti-CBASS protein ("Acb2") that forms a hexamer with three 3',3'-cGAMP molecules and reduces phospholipase activity. |
| APIS048 | CLAN018 | Ralstonia phage YO108_2 |