| AD families | AD genes | Defense system | CLAN ID | Phages/MGEs | References | Description |
|---|---|---|---|---|---|---|
| ADG.17 | ADG.17 | toxin-antitoxin (TA) | CLAN067 | Sulfolobus monocaudavirus SMV1 | PMID:38698035 | ADG.17 and its homologs in archaea viruses act as antitoxins to inhibit host toxin Doc. It's the first example of an inhibitor of an archaeal toxin-antitoxin immune system. |