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Seed proteins  | Seed genomic context  | Seed protein 3D structures  |  Structural homologs  |  Family infomation  | Homology to other families  | Family members, sources, and their hosts  

Seed protein information help

APIS family ID APIS010
Inhibited defense system restriction-modification (RM);bacteriophage exclusion (BREX)
CLAN ID CLAN009
Seed protein property
Accession ID Gene name Protein length Molecular weight Isoelectric point Charge
NP_041954.1 gene_page: Ocr 117 13809.08 3.6438 -26.0
Phage property
Phage Assembly id
T7 of E. coli GCF_000844825.1
PMID/References PMID:32338761 329108 12235377 11804597
PDB structures 1S7Z;
Pfam domains PF08684.13
Phrog phrog_2568
Host taxa d__Bacteria;p__Proteobacteria;c__Gammaproteobacteria;o__Enterobacterales;f__Enterobacteriaceae;g__Escherichia;s__Escherichia coli
Gene Location Start: 925;  End: 1278;  Strand: +
Description Ocr physically associates with BrxX methyltransferase to neutralizes their ability to both methylate and exclude incoming phage DNA. Ocr structurally mimics the DNA phosphate backbone and interacts directly with EcoKI (both the MTase and REase domain of this type I R–M enzyme), thereby interfering with the activity of this system.

Seed genomic context      Download table help

Genome accession Start End Strand Protein ID Length Molecular weight Charge Isoelectric point Function Phrog PFAM
NC_001604.1 925 1278 + NP_041954.1 117 13809.08 -26.0 3.6438 ocr-like anti-restriction phrog_2568 PF08684.13
NC_001604.1 1278 1433 + NP_041955.1 51 5752.54 -2.0 4.2992 hypothetical protein phrog_25044 ; phrog_7202
NC_001604.1 1496 1639 + NP_041956.1 47 4744.86 4.0 10.3264 hypothetical protein phrog_16572
NC_001604.1 1636 1794 + NP_041957.1 111 13235.34 22.5 11.9065 hypothetical protein phrog_8393 ; phrog_29241
NC_001604.1 1796 1972 + NP_041957.1 111 13235.34 22.5 11.9065 hypothetical protein phrog_8393 ; phrog_29241
NC_001604.1 2021 3100 + NP_041959.1 359 41123.79 0.5 6.5721 serine-threonine kinase phrog_18305 ; phrog_2828 ; phrog_15752

Seed genomic context- JBrowse     

PDB structure: 1S7Z ; Download help

Full Sequence      Download help

Structural homologs

No homologs found in AlphaFold database

Structure homologs against by esmdb (html) ; download full result table

Hit Query start Query end Hit start Hit end TMscore(ali) TMscore(avg)
MGYP002658425696.pdb 1 106 6 114 0.7328 0.6731

Family information      Download help

Fam ID Seed protein Member count Model Alignment
APIS010 NP_041954.1 42 HMM model Member alignment

Host Taxa distribution

Length distribution

Homology to other families       download full data without filtering help

Clan ID: CLAN009

Hit APIS family E-Value Query Start Query End Hit Start Hit End Immune system Seed protein
APIS085 3.99E-73 1 112 1 112 OL964750_00001
APIS077 1.11E-61 1 122 1 122 KU946962_00005
APIS087 2.91E-31 1 113 1 113 ON528733_00011

Family members, sources, and their hosts        help

Results of representative protein blast against members.
Member pident evalue bitscore qcovs phage host SourceDB Pfam Phrog
AY264776_00001 96.581 6.59e-76 228 100% Escherichia phage T7 Escherichia INPHARED PF08684 phrog_2568
AY264778_00001 97.436 1.88e-76 229 100% Escherichia phage T7 Escherichia INPHARED PF08684 phrog_2568
GU071091_00001 99.145 1.25e-77 233 100% Escherichia phage T7 Escherichia INPHARED PF08684 phrog_2568
IMGVR_UViG_3300038674_000002|3300038674|Ga0416709_08861_110_463 85.567 4.44e-54 173 83% IMGVR PF08684 phrog_2568
IMGVR_UViG_3300045988_000100|3300045988|Ga0495776_025784_34681_35049 93.396 1.84e-64 199 91% IMGVR PF08684 phrog_2568
JQ957925_00001 96.296 1.22e-69 213 92% Yersinia phage Y Yersinia INPHARED PF08684 phrog_2568 phrog_2828
JQ965701_00001 96.117 1.61e-66 204 88% Yersinia phage YpP-R Yersinia INPHARED PF08684 phrog_2568
KM242061_00009 94.175 4.30e-66 203 88% Escherichia phage CICC 80001 Escherichia INPHARED PF08684 phrog_2568
KP090454_00008 94.175 6.03e-65 201 88% Escherichia phage P694 Escherichia INPHARED PF08684 phrog_2568
KP313531_00001 88.350 1.48e-58 184 88% Citrobacter phage phiCFP-1 Citrobacter INPHARED PF08684 phrog_2568
KT008108_00001 86.408 4.14e-57 181 88% Yersinia phage phiYe-F10 Yersinia INPHARED PF08684 phrog_2568
KU927499_00002 97.087 8.73e-67 205 88% Escherichia phage 64795_ec1 Escherichia INPHARED PF08684 phrog_2568
KX130726_00015 87.379 4.52e-58 183 88% Escherichia phage ECA2 Escherichia INPHARED PF08684 phrog_2568
MG488277_00001 95.146 2.06e-65 202 88% Escherichia phage EG1 Escherichia INPHARED PF08684 phrog_2568
MH717099_00001 96.117 8.10e-67 205 88% Escherichia phage C5 Escherichia INPHARED PF08684 phrog_2568
MK310182_00001 96.117 1.54e-66 204 88% Escherichia phage NC-A Escherichia INPHARED PF08684 phrog_2568
MK542821_00008 95.146 1.18e-64 200 88% Escherichia phage HZP2 Escherichia INPHARED PF08684 phrog_2568
MK685668_00045 95.614 9.95e-74 223 97% Shigella phage VB_Ship_A7 Shigella INPHARED PF08684 phrog_2568
MN098329_00001 95.726 4.76e-74 223 100% Serratia phage Pila Serratia INPHARED PF08684 phrog_2568
MN481365_00048 96.117 6.35e-67 206 88% Escherichia phage vB_EcoP_PHB19 Escherichia INPHARED PF08684 phrog_2568
MN481366_00002 97.087 3.47e-67 206 88% Escherichia phage vB_EcoP_PHB20 Escherichia INPHARED PF08684 phrog_2568
MT350293_00049 95.536 1.62e-65 202 96% Enterococcus phage EFA-2 Enterococcus INPHARED PF08684 phrog_2568
MT543041_00001 96.117 8.86e-65 200 88% Serratia phage vB_SmaP-UFV01 Serratia INPHARED PF08684 phrog_2568
MW074885_00041 98.261 6.53e-75 226 98% Escherichia phage JB01 Escherichia INPHARED PF08684 phrog_2568
MZ220766_00001 93.878 1.34e-61 192 84% Edwardsiella phage PVN09 Edwardsiella INPHARED PF08684 phrog_2568
MZ375280_00001 99.145 6.29e-77 231 100% Escherichia phage T7 Escherichia INPHARED PF08684 phrog_2568
MZ375284_00001 98.291 5.01e-76 228 100% Escherichia phage T7 Escherichia INPHARED PF08684 phrog_2568
MZ501078_00006 96.117 2.56e-66 204 88% Escherichia phage JacobBurckhardt Escherichia INPHARED PF08684 phrog_2568
MZ501081_00008 95.283 6.14e-68 208 91% Escherichia phage JeanTinguely Escherichia INPHARED PF08684 phrog_2568
MZ833439_00001 94.175 2.13e-64 199 88% Enterobacteria phage AH67C600_Q5 Enterobacteria INPHARED PF08684 phrog_2568
NP_041954.1 100.000 1.33e-84 233 100% T7 of E. coli Escherichia coli NCBI PF08684 phrog_2568
OK042080_00001 84.466 1.15e-57 182 88% Yersinia phage vB_YenP_Rambo Yersinia INPHARED PF08684 phrog_2568
OL964741_00001 99.145 3.67e-77 231 100% Escherichia phage T7 Escherichia INPHARED PF08684 phrog_2568
OM630586_00024 97.087 8.09e-66 202 88% Escherichia phage vB_EcoP_LNA7 Escherichia INPHARED PF08684 phrog_2568
ON528715_00007 97.087 2.42e-67 206 88% Shigella phage ESh1 Shigella INPHARED PF08684 phrog_2568
ON528717_00047 96.000 7.07e-65 200 85% Shigella phage ESh3 Shigella INPHARED PF08684 phrog_2568
ON528719_00010 97.087 3.47e-67 206 88% Shigella phage ESh6 Shigella INPHARED PF08684 phrog_2568
ON568193_00001 86.408 8.67e-57 180 88% Cedecea phage Yanou Cedecea INPHARED PF08684 phrog_2568
ON886116_00005 96.117 3.80e-66 204 88% Salmonella phage PSP2-22 Salmonella INPHARED PF08684 phrog_2568
OP331230_00017 95.726 1.96e-73 222 100% Escherichia phage 04922B Escherichia INPHARED PF08684 phrog_2568
uvig_395422_49 95.146 7.92e-66 202 88% GPD PF08684 phrog_2568
uvig_557579_43 98.058 1.12e-67 207 88% GPD PF08684 phrog_2568
APIS Contig Range
APIS010 NC_001604.1 925 - 3100

Gene cluster comparison plot by clinker      Download html