| APIS family ID |
APIS010
|
| Inhibited defense system |
restriction-modification (RM);bacteriophage exclusion (BREX)
|
| CLAN ID |
CLAN009
|
| Seed protein property |
| Accession ID |
Gene name |
Protein length |
Molecular weight |
Isoelectric point |
Charge |
|
NP_041954.1
|
gene_page: Ocr |
117 |
13809.08 |
3.6438 |
-26.0 |
|
| Phage property |
|
| PMID/References |
PMID:32338761 329108 12235377 11804597
|
| PDB structures |
1S7Z;
|
| Pfam domains |
PF08684.13
|
| Phrog |
phrog_2568
|
| Host taxa |
d__Bacteria;p__Proteobacteria;c__Gammaproteobacteria;o__Enterobacterales;f__Enterobacteriaceae;g__Escherichia;s__Escherichia coli
|
| Gene Location |
Start: 925;
End: 1278;
Strand: +
|
| Description |
Ocr physically associates with BrxX methyltransferase to neutralizes their ability to both methylate and exclude incoming phage DNA. Ocr structurally mimics the DNA phosphate backbone and interacts directly with EcoKI (both the MTase and REase domain of this type I R–M enzyme), thereby interfering with the activity of this system.
|
