| APIS family ID | APIS027 | |||||||||||||
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| Inhibited defense system | defence-associated sirtuin (DSR) | |||||||||||||
| CLAN ID | CLAN026 | |||||||||||||
| Seed protein property |
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| Phage property |
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| PMID/References | PMID:36192536 | |||||||||||||
| PDB structures | ; | |||||||||||||
| Pfam domains | ||||||||||||||
| Phrog | phrog_37006 | |||||||||||||
| Host taxa | d__Bacteria;p__Firmicutes;c__Bacilli;o__Bacillales;f__Bacillaceae;g__Bacillus;s__Bacillus subtilis | |||||||||||||
| Gene Location | Start: ; End: ; Strand: | |||||||||||||
| Description | DSAD1 is a phage anti-DSR2 protein that binds and inhibits Defence-associated sirtuins (DSR2). In bacteria, N-terminal sirtuin (SIR2) domains within DSR2 were shown to participate in defence systems including prokaryotic argonautes (pAgo), Thoeris, AVAST, defence-associated sirtuin (DSR), etc. | |||||||||||||
pTM is for the estimate of the TM-score, which is obtained from a pairwise error prediction. The higher pTM score indicates better model quality.
pLDDT is for per-residue accuracy of the structure, which representes the quality of the residue. A higher value indicates better prediction accuracy. More detail please see AlphaFold .
| Fam ID | Seed protein | Member count | Model | Alignment | APIS027 | WP_004399562.1 | 4 | HMM model | Member alignment |
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| Member | pident | evalue | bitscore | qcovs | phage | host | SourceDB | Pfam | Phrog |
|---|---|---|---|---|---|---|---|---|---|
| IMGVR_UViG_2518645535_000002|2518645535|2518770019 | 100.000 | 5.40e-82 | 244 | 100% | Bacillus subtilis | IMGVR | phrog_37006 | ||
| IMGVR_UViG_2908369612_000002|2908369612|2908372442 | 85.000 | 3.40e-67 | 206 | 100% | Bacillus atrophaeus | IMGVR | phrog_37006 | ||
| IMGVR_UViG_3300011580_000013|3300011580|Ga0121001_100011177 | 100.000 | 8.28e-82 | 243 | 100% | Bacillus | IMGVR | phrog_37006 | ||
| WP_004399562.1 | 100.000 | 2.06e-88 | 243 | 100% | SPbeta phages of B. subtilis | Bacillus subtilis | NCBI | phrog_37006 |