| AD families | AD genes | Defense system | CLAN ID | Phages/MGEs | References | Description |
|---|---|---|---|---|---|---|
| APIS012 | tifA | toxin-antitoxin (TA) | CLAN011 | T4 of E. coli | PMID:35924892 | Original gene 61.4, experimentally evolved T4 phage to overcome a phage-defensive toxin-antitoxin system (toxIN) in E. coli. Through recombination, T4 rapidly acquires segmental amplifications of a previously uncharacterized gene, now named tifA, encoding an inhibitor of the toxin, ToxN. |
| APIS086 | CLAN011 | Escherichia phage vB_EcoM_CE1 |