| AD families | AD genes | Defense system | CLAN ID | Phages/MGEs | References | Description |
|---|---|---|---|---|---|---|
| APIS104 | narp2_nampt | NAD+ reconstitution pathway (NARP) | CLAN043 | Vibrio phage KVP40 | Osterman et al., 2024 | Nicotinamide phosphoribosyltransferase activity (Nampt), capable of producing NMN from PRPP and nicotinamide. |
| APIS197 | narp1_namat | NAD+ reconstitution pathway (NARP) | CLAN043 | Escherichia phage JohannRWettstein | Osterman et al., 2024 | Phage enzyme Nicotinamide ADPR-transferase (Namat) |