| APIS family ID | APIS011 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Inhibited defense system | toxin-antitoxin (TA) | |||||||||||||
| CLAN ID | CLAN023 | |||||||||||||
| Seed protein property |
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| Phage property |
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| PMID/References | PMID:23478446 | |||||||||||||
| PDB structures | ; | |||||||||||||
| Pfam domains | PF17574.5 | |||||||||||||
| Phrog | phrog_2254 | |||||||||||||
| Host taxa | d__Bacteria;p__Proteobacteria;c__Gammaproteobacteria;o__Enterobacterales;f__Enterobacteriaceae;g__Escherichia;s__Escherichia coli | |||||||||||||
| Gene Location | Start: 13584; End: 13853; Strand: + | |||||||||||||
| Description | Protein gp4.5 allows T7 to block Lon (protease) from degrading antitoxins (the SanTA system in E. coli), including SanaA, thereby preventing liberation of SanaT. However, beyond a possible interaction between gp4.5 and Lon in uninfected cells, this speculative model remains untested. | |||||||||||||
| Genome accession | Start | End | Strand | Protein ID | Length | Molecular weight | Charge | Isoelectric point | Function | Phrog | PFAM |
|---|---|---|---|---|---|---|---|---|---|---|---|
| NC_001604.1 | 11565 | 13265 | + | NP_041975.1 | 566 | 62655.45 | -11.5 | 5.2337 | DNA primase/helicase | phrog_239 ; phrog_37627 ; phrog_47 | PF08273.15 ;PF13155.9 ;PF03796.18 |
| NC_001604.1 | 11635 | 11757 | + | NP_041976.1 | 40 | 4397.03 | 4.0 | 10.8565 | hypothetical protein | phrog_20075 | |
| NC_001604.1 | 11754 | 13265 | + | NP_041977.1 | 503 | 55742.97 | -10.0 | 5.2007 | DNA primase/helicase | phrog_239 ; phrog_37627 ; phrog_47 | PF13155.9 ;PF03796.18 |
| NC_001604.1 | 12988 | 13326 | + | NP_041978.1 | 112 | 12653.76 | 5.5 | 9.8477 | hypothetical protein | phrog_5140 | PF17576.5 |
| NC_001604.1 | 13352 | 13564 | + | NP_041979.1 | 70 | 7927.14 | 5.0 | 10.7019 | hypothetical protein | phrog_1950 | PF17565.5 |
| NC_001604.1 | 13584 | 13853 | + | NP_041980.1 | 89 | 10091.46 | 5.5 | 10.5538 | hypothetical protein | phrog_2254 | PF17574.5 |
| NC_001604.1 | 13927 | 14334 | + | NP_041981.1 | 135 | 15208.56 | 8.5 | 10.0361 | hypothetical protein | phrog_4023 | |
| NC_001604.1 | 14353 | 16467 | + | NP_041982.1 | 704 | 79691.65 | -1.0 | 6.4437 | DNA polymerase I | phrog_24147 ; phrog_17 ; phrog_15971 ; phrog_6375 ; phrog_403 ; phrog_38876 ; phrog_9565 ; phrog_16667 | PF00476.23 |
| NC_001604.1 | 16483 | 16839 | + | NP_041983.1 | 118 | 13067.05 | 3.5 | 8.6691 | hypothetical protein | phrog_5018 | PF11645.11 |
| NC_001604.1 | 16851 | 17147 | + | NP_041984.1 | 169 | 18712.73 | 9.0 | 9.7615 | hypothetical protein | phrog_17900 ; phrog_1452 ; phrog_1334 | PF11247.11 |
| NC_001604.1 | 17147 | 17359 | + | NP_041984.1 | 169 | 18712.73 | 9.0 | 9.7615 | hypothetical protein | phrog_17900 ; phrog_1452 ; phrog_1334 | PF11247.11 |
pTM is for the estimate of the TM-score, which is obtained from a pairwise error prediction. The higher pTM score indicates better model quality.
pLDDT is for per-residue accuracy of the structure, which representes the quality of the residue. A higher value indicates better prediction accuracy. More detail please see AlphaFold .
| Hit | Query start | Query end | Hit start | Hit end | TMscore(ali) | TMscore(avg) |
|---|---|---|---|---|---|---|
| MGYP003595835577.pdb | 1 | 86 | 1 | 85 | 0.7503 | 0.7168 |
| Fam ID | Seed protein | Member count | Model | Alignment | APIS011 | NP_041980.1 | 43 | HMM model | Member alignment |
|---|
| Hit APIS family | E-Value | Query Start | Query End | Hit Start | Hit End | Immune system | Seed protein |
|---|---|---|---|---|---|---|---|
| APIS078 | 6.20E-33 | 1 | 73 | 1 | 73 | KX078568_00026 | |
| APIS080 | 6.25E-32 | 4 | 87 | 9 | 90 | ON602753_00020 | |
| APIS084 | 5.37E-29 | 4 | 72 | 9 | 77 | MW001769_00023 |
| Member | pident | evalue | bitscore | qcovs | phage | host | SourceDB | Pfam | Phrog |
|---|---|---|---|---|---|---|---|---|---|
| AY264776_00018 | 100.000 | 1.02e-57 | 181 | 100% | Escherichia phage T7 | Escherichia | INPHARED | PF17574 | phrog_2254 |
| AY264778_00021 | 97.753 | 9.19e-57 | 177 | 100% | Escherichia phage T7 | Escherichia | INPHARED | PF17574 | phrog_2254 |
| EU734174_00021 | 96.512 | 3.47e-53 | 169 | 97% | Escherichia phage 13a | Escherichia | INPHARED | PF17574 | phrog_2254 |
| FR667955_00018 | 95.506 | 2.51e-55 | 174 | 100% | Salmonella phage Vi06 | Salmonella | INPHARED | PF17574 | phrog_2254 |
| IMGVR_UViG_3300013307_000032|3300013307|Ga0157372_1000058425 | 59.740 | 6.33e-21 | 87.4 | 84% | IMGVR | PF17574 | phrog_2254 | ||
| IMGVR_UViG_3300045988_000100|3300045988|Ga0495776_025784_7113_7409 | 96.629 | 8.47e-56 | 175 | 100% | IMGVR | PF17574 | phrog_2254 | ||
| IMGVR_UViG_3300045988_000519|3300045988|Ga0495776_043652_12984_13274 | 97.701 | 6.20e-55 | 173 | 98% | IMGVR | PF17574 | phrog_2254 | ||
| IMGVR_UViG_3300045988_001011|3300045988|Ga0495776_127866_17262_17558 | 98.864 | 2.37e-56 | 177 | 99% | IMGVR | PF17574 | phrog_2254 | ||
| KM242061_00029 | 96.629 | 1.04e-55 | 175 | 100% | Escherichia phage CICC 80001 | Escherichia | INPHARED | PF17574 | phrog_2254 |
| MG488277_00025 | 96.629 | 1.19e-55 | 175 | 100% | Escherichia phage EG1 | Escherichia | INPHARED | PF17574 | phrog_2254 |
| MG832642_00027 | 97.753 | 1.07e-56 | 177 | 100% | Escherichia phage HZ2R8 | Escherichia | INPHARED | PF17574 | phrog_2254 |
| MG966531_00020 | 68.182 | 7.56e-37 | 127 | 99% | Escherichia phage Ebrios | Escherichia | INPHARED | PF17574 | phrog_2254 |
| MGV-GENOME-0262495_20 | 97.701 | 8.69e-55 | 172 | 98% | MGV | PF17574 | phrog_2254 | ||
| MGV-GENOME-0263483_29 | 97.753 | 3.14e-56 | 176 | 100% | MGV | PF17574 | phrog_2254 | ||
| MGV-GENOME-0265351_15 | 96.629 | 9.41e-56 | 175 | 100% | MGV | PF17574 | phrog_2254 | ||
| MH370477_00025 | 61.644 | 1.31e-23 | 94.4 | 82% | Escherichia phage SRT7 | Escherichia | INPHARED | PF17574 | phrog_2254 |
| MH382198_00028 | 97.701 | 1.04e-54 | 172 | 98% | Salmonella phage 3A_8767 | Salmonella | INPHARED | PF17574 | phrog_2254 |
| MK310182_00022 | 97.753 | 3.01e-56 | 176 | 100% | Escherichia phage NC-A | Escherichia | INPHARED | PF17574 | phrog_2254 |
| MK542821_00027 | 96.629 | 8.54e-56 | 175 | 100% | Escherichia phage HZP2 | Escherichia | INPHARED | PF17574 | phrog_2254 |
| MN184885_00032 | 62.500 | 1.25e-22 | 92.0 | 80% | Erwinia phage pEp_SNUABM_09 | Erwinia | INPHARED | PF17574 | phrog_2254 |
| MN450150_00019 | 63.380 | 1.69e-21 | 89.0 | 80% | Pantoea phage vB_PagP-SK1 | Pantoea | INPHARED | PF17574 | phrog_2254 |
| MN481365_00028 | 95.506 | 3.60e-55 | 173 | 100% | Escherichia phage vB_EcoP_PHB19 | Escherichia | INPHARED | PF17574 | phrog_2254 |
| MN481366_00020 | 96.629 | 1.17e-55 | 175 | 100% | Escherichia phage vB_EcoP_PHB20 | Escherichia | INPHARED | PF17574 | phrog_2254 |
| MT350293_00027 | 98.851 | 2.04e-55 | 174 | 98% | Enterococcus phage EFA-2 | Enterococcus | INPHARED | PF17574 | phrog_2254 |
| MT465573_00022 | 61.644 | 1.48e-23 | 94.0 | 82% | Escherichia phage P1723 | Escherichia | INPHARED | PF17574 | phrog_2254 |
| MT681669_00029 | 67.816 | 2.34e-36 | 126 | 98% | Aeromonas phage PZL-Ah1 | Aeromonas | INPHARED | PF17574 | phrog_2254 |
| MW074885_00011 | 95.506 | 4.53e-55 | 173 | 100% | Escherichia phage JB01 | Escherichia | INPHARED | PF17574 | phrog_2254 |
| MZ220766_00022 | 95.402 | 1.86e-53 | 169 | 98% | Edwardsiella phage PVN09 | Edwardsiella | INPHARED | PF17574 | phrog_2254 |
| MZ375287_00015 | 98.876 | 3.57e-57 | 179 | 100% | Escherichia phage T7 | Escherichia | INPHARED | PF17574 | phrog_2254 |
| MZ501081_00028 | 98.864 | 1.12e-56 | 177 | 99% | Escherichia phage JeanTinguely | Escherichia | INPHARED | PF17574 | phrog_2254 |
| MZ833439_00021 | 95.506 | 2.24e-55 | 174 | 100% | Enterobacteria phage AH67C600_Q5 | Enterobacteria | INPHARED | PF17574 | phrog_2254 |
| NP_041980.1 | 100.000 | 2.78e-64 | 180 | 100% | T7 of E. coli | Escherichia coli | NCBI | PF17574 | phrog_2254 |
| OK042080_00019 | 95.402 | 5.01e-53 | 168 | 98% | Yersinia phage vB_YenP_Rambo | Yersinia | INPHARED | PF17574 | phrog_2254 |
| OM630586_00042 | 97.753 | 7.88e-57 | 177 | 100% | Escherichia phage vB_EcoP_LNA7 | Escherichia | INPHARED | PF17574 | phrog_2254 |
| ON528716_00023 | 100.000 | 3.96e-56 | 176 | 98% | Shigella phage ESh2 | Shigella | INPHARED | PF17574 | phrog_2254 |
| ON528719_00030 | 94.382 | 4.12e-54 | 171 | 100% | Shigella phage ESh6 | Shigella | INPHARED | PF17574 | phrog_2254 |
| ON715521_00019 | 59.155 | 1.48e-22 | 91.7 | 80% | Erwinia phage Stepyanka | Erwinia | INPHARED | PF17574 | phrog_2254 |
| ON886116_00048 | 97.753 | 2.50e-56 | 176 | 100% | Salmonella phage PSP2-22 | Salmonella | INPHARED | PF17574 | phrog_2254 |
| OP331230_00040 | 98.876 | 5.25e-57 | 178 | 100% | Escherichia phage 04922B | Escherichia | INPHARED | PF17574 | phrog_2254 |
| OQ507919_00016 | 70.000 | 1.95e-28 | 106 | 89% | Escherichia phage vB_Ec_Tarrare | Escherichia | INPHARED | PF17574 | phrog_2254 |
| uvig_395422_28 | 96.629 | 3.79e-56 | 176 | 100% | GPD | PF17574 | phrog_2254 | ||
| uvig_481475_20 | 97.701 | 8.43e-55 | 172 | 98% | GPD | PF17574 | phrog_2254 | ||
| uvig_557579_21 | 97.753 | 7.88e-57 | 177 | 100% | GPD | PF17574 | phrog_2254 |
| APIS | Contig | Range |
|---|---|---|
| APIS011 | NC_001604.1 | 11565 - 17359 |