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Seed proteins  | Seed genomic context  | Seed protein 3D structures  |  Structural homologs  |  Family infomation  | Homology to other families  | Family members, sources, and their hosts  

Seed protein information help

APIS family ID APIS016
Inhibited defense system cyclic oligonucleotide-based antiphage signaling system (CBASS)
CLAN ID CLAN019
Seed protein property
Accession ID Gene name Protein length Molecular weight Isoelectric point Charge
NP_049750.1 gene_page: Acb1 152 17244.5 4.9749 -4.5
Phage property
Phage Assembly id
T4 of E. coli GCF_000836945.1
PMID/References PMID:35395152
PDB structures 7T26;
Pfam domains
Phrog phrog_755
Host taxa d__Bacteria;p__Proteobacteria;c__Gammaproteobacteria;o__Enterobacterales;f__Enterobacteriaceae;g__Escherichia;s__Escherichia coli
Gene Location Start: 73952;  End: 74410;  Strand: -
Description Acb1 rapidly degrades the CBASS signals 3′3′-cGAMP, cUA and cAAA, but does not cleave cGG.

Seed genomic context      Download table help

Genome accession Start End Strand Protein ID Length Molecular weight Charge Isoelectric point Function Phrog PFAM
NC_000866.4 71253 71918 - NP_049745.2 221 26073.77 14.5 10.0776 homing endonuclease phrog_7168 ; phrog_19446 ; phrog_37840 ; phrog_447 ; phrog_15209 ; phrog_314 PF01541.27
NC_000866.4 72628 72915 - NP_049746.1 95 11153.69 -3.0 4.8667 hypothetical protein phrog_2023
NC_000866.4 72918 73328 - NP_049747.1 136 16034.61 -6.0 4.6254 hypothetical protein phrog_17649 ; phrog_33719 ; phrog_4811 ; phrog_1411
NC_000866.4 73329 73514 - NP_049748.1 61 6557.94 1.0 7.7990 hypothetical protein phrog_1692
NC_000866.4 73591 73878 - NP_049749.1 95 10176.80 3.0 9.6274 internal virion protein phrog_4363 PF11634.11
NC_000866.4 73952 74410 - NP_049750.1 152 17244.53 -4.5 4.9749 RNA ligase phrog_755
NC_000866.4 74407 74649 - NP_049751.1 80 8730.81 -9.0 4.0694 tail fiber chaperone phrog_1002 PF17594.5
NC_000866.4 74649 75374 - NP_049752.1 241 27329.15 -5.5 4.8518 deoxynucleoside monophosphate kinase phrog_139
NC_000866.4 75424 75954 - NP_049753.1 176 19712.27 -9.5 4.1283 tail protein phrog_45 PF06841.15
NC_000866.4 76061 76885 - NP_049754.1 274 31610.09 31.0 10.7851 DNA end protector phrog_32288 ; phrog_429
NC_000866.4 76885 77337 - NP_049755.1 150 17627.41 12.5 10.3980 head closure phrog_14892 ; phrog_218 PF08722.14

Seed genomic context- JBrowse     

PDB structure: 7T26 ; Download help

Full Sequence      Download help

Structural homologs

No homologs found in AlphaFold database

Structure homologs against by esmdb (html) ; download full result table

Hit Query start Query end Hit start Hit end TMscore(ali) TMscore(avg)
MGYP001306717441.pdb 1 137 8 147 0.9749 0.9089
MGYP001124013561.pdb 1 137 8 144 0.9608 0.9075
MGYP001021327017.pdb 1 137 2 138 0.9445 0.9068
MGYP002769065333.pdb 1 137 9 147 0.9661 0.9034
MGYP003610834631.pdb 1 137 3 141 0.926 0.8928
MGYP003620843858.pdb 1 137 8 146 0.9459 0.8824
MGYP003608119546.pdb 1 137 7 148 0.9304 0.8708
MGYP003635017775.pdb 1 137 3 145 0.9189 0.8633
MGYP001774826977.pdb 1 137 11 149 0.9199 0.8566
MGYP003526094176.pdb 1 137 10 157 0.9417 0.854

Family information      Download help

Fam ID Seed protein Member count Model Alignment
APIS016 NP_049750.1 41 HMM model Member alignment

Host Taxa distribution

Length distribution

Homology to other families       help

Clan ID: CLAN019

APIS016 has no similar APIS family.

Family members, sources, and their hosts        help

Results of representative protein blast against members.
Member pident evalue bitscore qcovs phage host SourceDB Pfam Phrog
HM035025_00145 99.342 2.76e-108 313 100% Shigella phage Shfl2 Shigella INPHARED phrog_755
IMGVR_UViG_3300045988_154884|3300045988|Ga0495776_101933_102131_102586 88.079 1.30e-94 278 99% IMGVR phrog_755
IMGVR_UViG_651703089_000001|651703089|651709829 99.338 2.40e-107 310 99% IMGVR phrog_755
KX009778_00148 99.338 7.65e-108 311 99% Escherichia phage UFV-AREG1 Escherichia INPHARED phrog_755
MF001359_00146 99.342 1.06e-108 314 100% Escherichia phage EC121 Escherichia INPHARED phrog_755
MF001360_00175 100.000 8.29e-105 304 96% Escherichia phage ECO4 Escherichia INPHARED phrog_755
MGV-GENOME-0373836_158 100.000 3.25e-109 315 100% MGV phrog_755
MGV-GENOME-0375647_201 88.079 1.35e-94 278 99% MGV phrog_755
MGV-GENOME-0377517_209 86.093 7.04e-95 279 99% MGV phrog_755
MGV-GENOME-0377569_108 100.000 3.29e-108 312 99% MGV phrog_755
MGV-GENOME-0377573_125 86.093 1.07e-94 278 99% MGV phrog_755
MGV-GENOME-0377602_246 99.338 3.12e-107 310 99% MGV phrog_755
MGV-GENOME-0377637_9 85.430 3.46e-94 277 99% MGV phrog_755
MK327936_00142 99.338 7.75e-107 309 99% Escherichia phage vB_EcoM_G2540 Escherichia INPHARED phrog_755
MK373782_00151 84.768 3.98e-94 277 99% Escherichia phage vB_EcoM_KAW3E185 Escherichia INPHARED phrog_755
MK373786_00155 99.338 8.73e-108 311 99% Escherichia phage vB_EcoM_R5505 Escherichia INPHARED phrog_755
MK524178_00242 86.093 1.44e-94 278 99% Escherichia phage PHB12 Escherichia INPHARED phrog_755
MK962750_00147 99.342 9.01e-109 314 100% Shigella phage CM8 Shigella INPHARED phrog_755
MK962752_00155 99.338 1.15e-107 311 99% Shigella phage JK23 Shigella INPHARED phrog_755
MK962755_00149 99.342 2.19e-108 313 100% Shigella phage JK38 Shigella INPHARED phrog_755
MN648445_00012 85.430 3.34e-94 277 99% Escherichia phage FP43 Escherichia INPHARED phrog_755
MT446387_00104 98.675 6.50e-107 309 99% Escherichia phage TH09 Escherichia INPHARED phrog_755
MT682710_00039 98.013 6.96e-106 306 99% Escherichia phage vB_EcoM_FT Escherichia INPHARED phrog_755
MW341595_00202 99.338 6.56e-108 311 99% Shigella phage Sfk20 Shigella INPHARED phrog_755
MW749001_00151 99.338 1.03e-107 311 99% Escherichia phage vB_EcoM_Kelasse Escherichia INPHARED phrog_755
MZ311865_00060 86.093 1.03e-94 278 99% Escherichia phage vB_EcoM_LNA2 Escherichia INPHARED phrog_755
MZ501047_00254 85.430 1.01e-94 278 99% Escherichia phage AlbertHofmann Escherichia INPHARED phrog_755
MZ501056_00249 86.093 6.81e-95 279 99% Escherichia phage ChristianSchoenbein Escherichia INPHARED phrog_755
MZ502380_00147 98.052 4.82e-106 307 99% Escherichia phage vB_EcoM_Nami Escherichia INPHARED phrog_755
NP_049750.1 100.000 8.09e-116 315 100% T4 of E. coli Escherichia coli NCBI phrog_755
OK040907_00146 99.338 1.45e-107 311 99% Enterobacteria phage Ac3 Enterobacteria INPHARED phrog_755
OL770073_00167 99.338 5.69e-108 312 99% Escherichia phage vB_EcoM-RPN226 Escherichia INPHARED phrog_755
OL770074_00244 86.093 8.29e-95 278 99% Escherichia phage vB_EcoM-RPN187 Escherichia INPHARED phrog_755
OL870317_00149 99.342 9.73e-109 314 100% Escherichia phage UTI-E4 Escherichia INPHARED phrog_755
ON528740_00148 99.338 1.67e-107 311 99% Shigella phage ESh30 Shigella INPHARED phrog_755
OP611477_00195 99.338 1.09e-107 311 99% Escherichia virus CAM-21 Escherichia INPHARED phrog_755
OQ067374_00246 85.430 3.30e-94 277 99% Escherichia phage a20 Escherichia INPHARED phrog_755
OQ466432_00246 100.000 3.18e-108 312 99% Escherichia phage ADUt Escherichia INPHARED phrog_755
OQ703618_00035 84.768 4.11e-94 277 99% Escherichia phage GADS24 Escherichia INPHARED phrog_755
OQ721911_00151 99.338 4.88e-108 312 99% Escherichia phage vB_VIPECOOM03 Escherichia INPHARED phrog_755
uvig_225001_246 99.338 3.02e-107 310 99% GPD phrog_755
APIS Contig Range
APIS016 NC_000866.4 71253 - 77337

Gene cluster comparison plot by clinker      Download html