dbAPIS: a database of anti-prokaryotic immune systems

Seed protein information help

APIS family ID

APIS016

Inhibited defense system

cyclic oligonucleotide-based antiphage signaling system (CBASS)

CLAN ID

CLAN015

Seed protein property

Accession ID	Gene name	Protein length	Molecular weight	Isoelectric point	Charge
NP_049750.1	gene_page: Acb1	152	17244.53	4.9749	-4.5

Phage property

Phage	Assembly id
T4 of E. coli	GCF_000836945.1

PMID/References

PMID:35395152

PDB structures

7T26;

Pfam domains

Phrog

phrog_755

Host taxa

d__Bacteria;p__Proteobacteria;c__Gammaproteobacteria;o__Enterobacterales;f__Enterobacteriaceae;g__Escherichia;s__Escherichia coli

Gene Location

Start: 73952; End: 74410; Strand: -

Description

Acb1 rapidly degrades the CBASS signals 3′3′-cGAMP, cUA and cAAA, but does not cleave cGG.

Seed genomic context Download table help

Search:

Genome accession	Start	End	Strand	Protein ID	Length	Molecular weight	Charge	Isoelectric point	Function	Phrog	PFAM
NC_000866.4	71253	71918	-	NP_049745.2	221	26073.77	14.5	10.0776	homing endonuclease	phrog_7168 ; phrog_19446 ; phrog_37840 ; phrog_447 ; phrog_15209 ; phrog_314	PF01541.27
NC_000866.4	72628	72915	-	NP_049746.1	95	11153.69	-3.0	4.8667	hypothetical protein	phrog_2023
NC_000866.4	72918	73328	-	NP_049747.1	136	16034.61	-6.0	4.6254	hypothetical protein	phrog_17649 ; phrog_33719 ; phrog_4811 ; phrog_1411
NC_000866.4	73329	73514	-	NP_049748.1	61	6557.94	1.0	7.7990	hypothetical protein	phrog_1692
NC_000866.4	73591	73878	-	NP_049749.1	95	10176.80	3.0	9.6274	internal virion protein	phrog_4363	PF11634.11
NC_000866.4	73952	74410	-	NP_049750.1	152	17244.53	-4.5	4.9749	RNA ligase	phrog_755
NC_000866.4	74407	74649	-	NP_049751.1	80	8730.81	-9.0	4.0694	tail fiber chaperone	phrog_1002	PF17594.5
NC_000866.4	74649	75374	-	NP_049752.1	241	27329.15	-5.5	4.8518	deoxynucleoside monophosphate kinase	phrog_139
NC_000866.4	75424	75954	-	NP_049753.1	176	19712.27	-9.5	4.1283	tail protein	phrog_45	PF06841.15
NC_000866.4	76061	76885	-	NP_049754.1	274	31610.09	31.0	10.7851	DNA end protector	phrog_32288 ; phrog_429
NC_000866.4	76885	77337	-	NP_049755.1	150	17627.41	12.5	10.3980	head closure	phrog_14892 ; phrog_218	PF08722.14

Showing 1 to 11 of 11 entries

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Seed genomic context- JBrowse

PDB structure: 7T26 ; Download help

Full Sequence Download help

MMEFKDFSTG LYVAAKFSEL TLDALEELQR SLRVPNPVPR EKIHSTICYS RVNVPYVPSS	60
GSFEVASSGH LEVWKTQDGS TLVLVLDSEY LRCRHMYARA LGATHDFDDY TPHITLSYNV	120
GPLSFSGDVQ IPVVLDREYK EPLKLDWADD LK	152

Structural homologs

No homologs found in AlphaFold database

Structure homologs against by esmdb (html) ; download full result table

Hit	Query start	Query end	Hit start	Hit end	TMscore(ali)	TMscore(avg)
MGYP001306717441.pdb	1	137	8	147	0.9749	0.9089
MGYP001124013561.pdb	1	137	8	144	0.9608	0.9075
MGYP001021327017.pdb	1	137	2	138	0.9445	0.9068
MGYP002769065333.pdb	1	137	9	147	0.9661	0.9034
MGYP003610834631.pdb	1	137	3	141	0.926	0.8928
MGYP003620843858.pdb	1	137	8	146	0.9459	0.8824
MGYP003608119546.pdb	1	137	7	148	0.9304	0.8708
MGYP003635017775.pdb	1	137	3	145	0.9189	0.8633
MGYP001774826977.pdb	1	137	11	149	0.9199	0.8566
MGYP003526094176.pdb	1	137	10	157	0.9417	0.854

Family information Download help

Fam ID	Seed protein	Member count	Model	Alignment
APIS016	NP_049750.1	41	HMM model	Member alignment

Host Taxa distribution

Length distribution

Homology to other families help

Clan ID: CLAN015

APIS016 has no similar APIS family.

Family members, sources, and their hosts help