Browse anti-prokaryotic immune system families by CLAN ID

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AD families	AD genes	Defense system	CLAN ID	Phages/MGEs	References	Description
APIS002	vs.4	cyclic oligonucleotide-based antiphage signaling system (CBASS)	CLAN002	T4 of E. coli	PMID:36848932	Vs.4 antagonized cGAS signaling by binding tightly to cGAMP (dissociation constant of approximately 30 nM) and sequestering it; Bioinformatic analyses identified 198 homologues of Vs.4 in diverse phages; belongs to PHROG 717.
APIS004	Acb2	cyclic oligonucleotide-based antiphage signaling system (CBASS)	CLAN002	PaMx33 of Pseudomonas aeruginosa	PMID:36750095	Anti-CBASS protein ("Acb2") that forms a hexamer with three 3',3'-cGAMP molecules and reduces phospholipase activity.
APIS048			CLAN002	Ralstonia phage YO108_2

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