dbAPIS: a database of anti-prokaryotic immune systems

Seed protein information help

APIS family ID

APIS004

Inhibited defense system

cyclic oligonucleotide-based antiphage signaling system (CBASS)

CLAN ID

CLAN002

Seed protein property

Accession ID	Gene name	Protein length	Molecular weight	Isoelectric point	Charge
ANA48877.1	gene_page: Acb2	93	10699.13	6.7258	0.5

Phage property

Phage	Assembly id
PaMx33 of Pseudomonas aeruginosa	GCA_002757475.1

PMID/References

PMID:36750095

PDB structures

8H2X;

Pfam domains

Phrog

phrog_29522,phrog_717

Host taxa

d__Bacteria;p__Proteobacteria;c__Gammaproteobacteria;o__Pseudomonadales;f__Pseudomonadaceae;g__Pseudomonas;s__Pseudomonas aeruginosa

Gene Location

Start: 24098; End: 24379; Strand: -

Description

Anti-CBASS protein ("Acb2") that forms a hexamer with three 3',3'-cGAMP molecules and reduces phospholipase activity.

Seed genomic context Download table help

Search:

Genome accession	Start	End	Strand	Protein ID	Length	Molecular weight	Charge	Isoelectric point	Function	Phrog	PFAM
KU884561.1	12321	12692	+	ANA48872.1	123	13711.84	-1.0	5.0953	hypothetical protein	phrog_15925
KU884561.1	12703	15798	+	ANA48873.1	1031	115474.27	-29.5	4.6028	structural protein	phrog_25726 ; phrog_20849 ; phrog_16563 ; phrog_37462
KU884561.1	15809	16726	+	ANA48874.1	305	31387.72	-1.0	5.2890	structural protein	phrog_16266
KU884561.1	16740	18473	+	ANA48875.1	577	63373.91	-9.5	4.7716	structural protein	phrog_15195
KU884561.1	18491	24040	+	ANA48876.1	1849	203831.04	-5.0	6.1487	structural protein	phrog_26138 ; phrog_12813 ; phrog_16165 ; phrog_35393
KU884561.1	24098	24379	-	ANA48877.1	93	10699.13	0.5	6.7258	hypothetical protein	phrog_29522 ; phrog_717
KU884561.1	24381	24893	-	ANA48878.1	170	19320.72	-13.5	4.2091	hypothetical protein	phrog_15622
KU884561.1	25028	25282	-	ANA48879.1	84	9472.00	2.0	9.0439	hypothetical protein	phrog_16359
KU884561.1	25261	26151	-	ANA48880.1	296	33655.64	-1.5	5.8623	putative pyrophosphohydrolase	phrog_10631 ; phrog_229 ; phrog_16522
KU884561.1	26154	27407	-	ANA48881.1	417	47637.95	2.5	6.8881	putative primase	phrog_14296 ; phrog_17599 ; phrog_35120	PF13148.9 ;PF13148.9
KU884561.1	27326	29731	-	ANA48882.1	801	92426.48	17.0	8.7730	putative DNA polymerase I		PF00476.23

Showing 1 to 11 of 11 entries

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Seed genomic context- JBrowse

PDB structure: 8H2X ; Download help

Full Sequence Download help

MDNQHKKIKG YRDLSQEEID MMNRVKELGS QFEKLIQDVS DHLRGQYNAS LHNRDEITRI	60
ANAEPGRWLA IGKTDIQTGM MAIIRAIAQP DSF	93

Structural homologs

No homologs found in AlphaFold database

Structure homologs against by esmdb (html) ; download full result table

Hit	Query start	Query end	Hit start	Hit end	TMscore(ali)	TMscore(avg)
MGYP003566141174.pdb	1	86	9	91	0.8483	0.7901

Family information Download help

Fam ID	Seed protein	Member count	Model	Alignment
APIS004	ANA48877.1	206	HMM model	Member alignment

Host Taxa distribution

Length distribution

Homology to other families download full data without filtering help

Clan ID: CLAN002

Search:

Hit APIS family	E-Value	Query Start	Query End	Hit Start	Hit End	Immune system	Seed protein
APIS002	1.31E-07	6	83	4	87	cyclic oligonucleotide-based antiphage signaling system (CBASS)	NP_049728.1
APIS048	9.84E-50	1	84	22	129		ON170191_00003

Showing 1 to 2 of 2 entries

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Family members, sources, and their hosts help

Search:

Member	pident	evalue	bitscore	qcovs	phage	host	SourceDB	Phrog
ANA48877.1	100.000	8.87e-70	194	100%	PaMx33 of Pseudomonas aeruginosa	Pseudomonas aeruginosa	NCBI	phrog_29522 phrog_717
DQ163914_00021	95.699	3.88e-60	186	100%	Pseudomonas phage 119X	Pseudomonas	INPHARED	phrog_29522 phrog_717
EF057797_00030	46.491	3.20e-25	99.4	97%	Vibrio phage VP882	Vibrio	INPHARED	phrog_29522 phrog_717
HM032710_00014	45.161	2.75e-21	87.8	100%	Acinetobacter phage Ac42	Acinetobacter	INPHARED	phrog_29522 phrog_717
IMGVR_UViG_2032320007_000040\|2032320007\|ATEDB_6414140	50.000	2.97e-24	96.3	98%			IMGVR	phrog_29522
IMGVR_UViG_2502545037_000001\|2502545037\|2502674691	51.000	2.12e-25	99.4	97%		Halomonas venusta	IMGVR	phrog_29522 phrog_717
IMGVR_UViG_2504643027_000008\|2504643027\|2504733478	46.000	2.97e-25	99.0	100%		Acinetobacter baumannii	IMGVR	phrog_29522 phrog_717
IMGVR_UViG_2508501040_000002\|2508501040\|2508685179	47.706	5.13e-22	90.9	97%		Paraburkholderia sp000178415	IMGVR	phrog_29522 phrog_717
IMGVR_UViG_2524614738_000005\|2524614738\|2525595533	51.613	5.94e-26	100	98%		Pseudomonas aeruginosa	IMGVR	phrog_29522 phrog_717
IMGVR_UViG_2526164572_000005\|2526164572\|2526434306	47.059	4.13e-23	93.6	98%		Pseudomonas_E khazarica	IMGVR	phrog_29522 phrog_717

Showing 1 to 10 of 206 entries

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APIS	Contig	Range
APIS004	KU884561.1	12321 - 29731

Seed protein information help

Seed genomic context Download table help

Seed genomic context- JBrowse

PDB structure: 8H2X ; Download help

Full Sequence Download help

Structural homologs

No homologs found in AlphaFold database

Structure homologs against by esmdb (html) ; download full result table

Family information Download help

Host Taxa distribution

Length distribution

Homology to other families download full data without filtering help

Clan ID: CLAN002

Family members, sources, and their hosts help

Results of representative protein blast against members.

Gene cluster comparison plot by clinker Download html