| APIS family ID | APIS004 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Inhibited defense system | cyclic oligonucleotide-based antiphage signaling system (CBASS) | |||||||||||||
| CLAN ID | CLAN018 | |||||||||||||
| Seed protein property |
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| Phage property |
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| PMID/References | PMID:36750095 | |||||||||||||
| PDB structures | 8H2X; | |||||||||||||
| Pfam domains | ||||||||||||||
| Phrog | phrog_29522,phrog_717 | |||||||||||||
| Host taxa | d__Bacteria;p__Proteobacteria;c__Gammaproteobacteria;o__Pseudomonadales;f__Pseudomonadaceae;g__Pseudomonas;s__Pseudomonas aeruginosa | |||||||||||||
| Gene Location | Start: 24098; End: 24379; Strand: - | |||||||||||||
| Description | Anti-CBASS protein ("Acb2") that forms a hexamer with three 3',3'-cGAMP molecules and reduces phospholipase activity. | |||||||||||||
| Genome accession | Start | End | Strand | Protein ID | Length | Molecular weight | Charge | Isoelectric point | Function | Phrog | PFAM |
|---|---|---|---|---|---|---|---|---|---|---|---|
| KU884561.1 | 12321 | 12692 | + | ANA48872.1 | 123 | 13711.84 | -1.0 | 5.0953 | hypothetical protein | phrog_15925 | |
| KU884561.1 | 12703 | 15798 | + | ANA48873.1 | 1031 | 115474.27 | -29.5 | 4.6028 | structural protein | phrog_25726 ; phrog_20849 ; phrog_16563 ; phrog_37462 | |
| KU884561.1 | 15809 | 16726 | + | ANA48874.1 | 305 | 31387.72 | -1.0 | 5.2890 | structural protein | phrog_16266 | |
| KU884561.1 | 16740 | 18473 | + | ANA48875.1 | 577 | 63373.91 | -9.5 | 4.7716 | structural protein | phrog_15195 | |
| KU884561.1 | 18491 | 24040 | + | ANA48876.1 | 1849 | 203831.04 | -5.0 | 6.1487 | structural protein | phrog_26138 ; phrog_12813 ; phrog_16165 ; phrog_35393 | |
| KU884561.1 | 24098 | 24379 | - | ANA48877.1 | 93 | 10699.13 | 0.5 | 6.7258 | hypothetical protein | phrog_29522 ; phrog_717 | |
| KU884561.1 | 24381 | 24893 | - | ANA48878.1 | 170 | 19320.72 | -13.5 | 4.2091 | hypothetical protein | phrog_15622 | |
| KU884561.1 | 25028 | 25282 | - | ANA48879.1 | 84 | 9472.00 | 2.0 | 9.0439 | hypothetical protein | phrog_16359 | |
| KU884561.1 | 25261 | 26151 | - | ANA48880.1 | 296 | 33655.64 | -1.5 | 5.8623 | putative pyrophosphohydrolase | phrog_10631 ; phrog_229 ; phrog_16522 | |
| KU884561.1 | 26154 | 27407 | - | ANA48881.1 | 417 | 47637.95 | 2.5 | 6.8881 | putative primase | phrog_14296 ; phrog_17599 ; phrog_35120 | PF13148.9 ;PF13148.9 |
| KU884561.1 | 27326 | 29731 | - | ANA48882.1 | 801 | 92426.48 | 17.0 | 8.7730 | putative DNA polymerase I | PF00476.23 |
| Hit | Query start | Query end | Hit start | Hit end | TMscore(ali) | TMscore(avg) |
|---|---|---|---|---|---|---|
| MGYP003566141174.pdb | 1 | 86 | 9 | 91 | 0.8483 | 0.7901 |
| Fam ID | Seed protein | Member count | Model | Alignment | APIS004 | ANA48877.1 | 206 | HMM model | Member alignment |
|---|
| Hit APIS family | E-Value | Query Start | Query End | Hit Start | Hit End | Immune system | Seed protein |
|---|---|---|---|---|---|---|---|
| APIS048 | 9.84E-50 | 1 | 84 | 22 | 129 | ON170191_00003 | |
| APIS002 | 1.31E-07 | 6 | 83 | 4 | 87 | cyclic oligonucleotide-based antiphage signaling system (CBASS) | NP_049728.1 |
| APIS | Contig | Range |
|---|---|---|
| APIS004 | KU884561.1 | 12321 - 29731 |