| AD families | AD genes | Defense system | CLAN ID | Phages/MGEs | References | Description |
|---|---|---|---|---|---|---|
| APIS007 | KlcA | restriction-modification (RM) | CLAN006 | IncP-1b plasmid of Bordetella pertussis | PMID:20007596 | ArdB and KlcA act as anti-restriction proteins and inhibit the four main families of Type I RM systems in vivo. |
| APIS037 | CLAN006 | |||||
| APIS038 | CLAN006 | |||||
| APIS039 | CLAN006 | |||||
| APIS055 | CLAN006 | Pseudomonas phage Churro | ||||
| APIS069 | CLAN006 | |||||
| APIS100 | CLAN006 | |||||
| ArdB | ArdB | restriction-modification (RM) | CLAN006 | plasmid pKM101 of E. coli | PMID:8393008 | Like ArdA, ArdB efficiently inhibits restriction by members of the three known families of type I systems of E. coli and only slightly affects the type II enzyme, EcoRI. |