| Basic Information | |
|---|---|
| Species | Capsella rubella |
| Cazyme ID | Carubv10004531m |
| Family | GH79 |
| Protein Properties | Length: 545 Molecular Weight: 60644 Isoelectric Point: 7.6479 |
| Chromosome | Chromosome/Scaffold: 7 Start: 13347617 End: 13352856 |
| Description | glucuronidase 3 |
| View CDS | |
| External Links |
|---|
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
 | |||
| Family | Start | End | Evalue |
| GH79 | 53 | 537 | 0 |
| DEDFICATLDWWPPEKCDYGTCSWDHASILNLDLNNIIFQNAIKAFAPLKIRIGGTLQDLVIYETPDQKQPCVPFTQNSSIIFGYTQGCLPMHRWGELNA FFSKTGAKIIFGLNALSGRSINPKGEAVGAWDSTNAESFIRYTAQSNYTVDGWELGNELCGGGVGTRVAANQYAIDTINLRNVVNRVYKNVSPMPLVIGP GGFFEDAWFSEYLKKAGNSLNATTHHIYDLGPGVDEHLIEKILNPSYLDQEANTFRSLKNVIKKSSTKAVSWVGESGGAYNSGRNLVSNAFVYSFWYLDQ LGMASVYDTKTYCRQSLIGGNYGLLNTTNFTPNPDYYSALIWRKLMGRKALFTSFSGTKKIRSYAHCARQSKGITVLLMNLDNTTTVLAKVELNNTFSLR HTKHVKSYKRATSQLSWDSDGEVQREEYHLTAKDGNLHSQTMLLNGNALQVNSMGDIPPIEPIHINSTEPITIAPYSIVFVHMPS | |||
| Full Sequence |
|---|
| Protein Sequence Length: 545 Download |
| MREKCCRQIW FFKVLFFLCC VLQFLDYTVS SAVEEDNTGK VFVYGRAAVG TIDEDFICAT 60 LDWWPPEKCD YGTCSWDHAS ILNLDLNNII FQNAIKAFAP LKIRIGGTLQ DLVIYETPDQ 120 KQPCVPFTQN SSIIFGYTQG CLPMHRWGEL NAFFSKTGAK IIFGLNALSG RSINPKGEAV 180 GAWDSTNAES FIRYTAQSNY TVDGWELGNE LCGGGVGTRV AANQYAIDTI NLRNVVNRVY 240 KNVSPMPLVI GPGGFFEDAW FSEYLKKAGN SLNATTHHIY DLGPGVDEHL IEKILNPSYL 300 DQEANTFRSL KNVIKKSSTK AVSWVGESGG AYNSGRNLVS NAFVYSFWYL DQLGMASVYD 360 TKTYCRQSLI GGNYGLLNTT NFTPNPDYYS ALIWRKLMGR KALFTSFSGT KKIRSYAHCA 420 RQSKGITVLL MNLDNTTTVL AKVELNNTFS LRHTKHVKSY KRATSQLSWD SDGEVQREEY 480 HLTAKDGNLH SQTMLLNGNA LQVNSMGDIP PIEPIHINST EPITIAPYSI VFVHMPSVVV 540 PACA* |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
 | ||||||||
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03662 | Glyco_hydro_79n | 0 | 39 | 354 | 317 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| DDBJ | BAB10787.1 | 0 | 7 | 544 | 4 | 536 | unnamed protein product [Arabidopsis thaliana] |
| EMBL | CBI25561.1 | 0 | 39 | 543 | 30 | 532 | unnamed protein product [Vitis vinifera] |
| RefSeq | NP_851093.1 | 0 | 7 | 544 | 4 | 536 | AtGUS3 (Arabidopsis thaliana glucuronidase 3); beta-glucuronidase |
| RefSeq | XP_002263173.1 | 0 | 39 | 543 | 41 | 558 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002324603.1 | 0 | 39 | 544 | 1 | 506 | predicted protein [Populus trichocarpa] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3vo0_A | 0.0000002 | 150 | 439 | 124 | 406 | B Chain B, Crystal Structure Of The Complex Between Pectin Methylesterase And Its Inhibitor Protein |
| PDB | 3vnz_A | 0.0000002 | 150 | 439 | 124 | 406 | B Chain B, Crystal Structure Of The Complex Between Pectin Methylesterase And Its Inhibitor Protein |
| PDB | 3vny_A | 0.0000002 | 150 | 439 | 124 | 406 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
