| Basic Information | |
|---|---|
| Species | Citrus sinensis |
| Cazyme ID | orange1.1g008834m |
| Family | GH79 |
| Protein Properties | Length: 552 Molecular Weight: 61645 Isoelectric Point: 8.212 |
| Chromosome | Chromosome/Scaffold: 00122 Start: 127482 End: 133450 |
| Description | glucuronidase 2 |
| View CDS | |
| External Links |
|---|
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
 | |||
| Family | Start | End | Evalue |
| GH79 | 40 | 544 | 0 |
| DEHFICATVDWWPHDKCNYNHCPWGNSSVINLLHAIWYFQDLSHPLLANAIQAFQSLRIRIGGSLQDQVLYDVGDLKAPCHPFRKMKDGLFGFSKGCLHM QRWDELNQLFNRTRAIVSFGLNALHGRHNIRHNAWGGAWDSNNARDFLKYTISMGYQIDSWEYGNELSGRTSIGASVDAELYGKDLINLKNIINELYKNS SSKPTILAPGGFFDQEWYAKFLQVSGSNVVNGVTHHIYNLGPGVDPNLVSKILNPQRLSRVSETFGNLKQTIEKHGPWASAWVGESGGAYNSGGRHVSNT FVNSFWYLDQLGMSSKYNTKVYCRQTLVGGNYGLLNATTFIPNPDYYSALLWHRLMGKGVLSVATDGSSSLRSYAHCSKEREGITLLLINLSNQTDYVIS VHNSMNMKLTVKGKDINGESSLSRDIKRAVSWVGSTASDGHLTREEYHLTPKDGYLQSQTMVLNGIPLQLAEDEGIPKLDPVRVDVNSPIYITHLSIAFI VFPNF | |||
| Full Sequence |
|---|
| Protein Sequence Length: 552 Download |
| MGIFLSLFIY LISYLPVILA RDVTRVTIFV DATKTVATND EHFICATVDW WPHDKCNYNH 60 CPWGNSSVIN LLHAIWYFQD LSHPLLANAI QAFQSLRIRI GGSLQDQVLY DVGDLKAPCH 120 PFRKMKDGLF GFSKGCLHMQ RWDELNQLFN RTRAIVSFGL NALHGRHNIR HNAWGGAWDS 180 NNARDFLKYT ISMGYQIDSW EYGNELSGRT SIGASVDAEL YGKDLINLKN IINELYKNSS 240 SKPTILAPGG FFDQEWYAKF LQVSGSNVVN GVTHHIYNLG PGVDPNLVSK ILNPQRLSRV 300 SETFGNLKQT IEKHGPWASA WVGESGGAYN SGGRHVSNTF VNSFWYLDQL GMSSKYNTKV 360 YCRQTLVGGN YGLLNATTFI PNPDYYSALL WHRLMGKGVL SVATDGSSSL RSYAHCSKER 420 EGITLLLINL SNQTDYVISV HNSMNMKLTV KGKDINGESS LSRDIKRAVS WVGSTASDGH 480 LTREEYHLTP KDGYLQSQTM VLNGIPLQLA EDEGIPKLDP VRVDVNSPIY ITHLSIAFIV 540 FPNFSARACV V* |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
 | ||||||||
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03662 | Glyco_hydro_79n | 0 | 25 | 351 | 327 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CBI15157.1 | 0 | 15 | 550 | 14 | 513 | unnamed protein product [Vitis vinifera] |
| RefSeq | NP_196400.2 | 0 | 1 | 549 | 1 | 542 | AtGUS2 (Arabidopsis thaliana glucuronidase 2); beta-glucuronidase |
| RefSeq | XP_002284470.1 | 0 | 15 | 550 | 14 | 539 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002321464.1 | 0 | 1 | 550 | 1 | 541 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002514696.1 | 0 | 16 | 550 | 15 | 539 | Heparanase-2, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3vo0_A | 0.0006 | 176 | 439 | 142 | 409 | A Chain A, Crystal Structure Of Barley Beta-D-Glucan Glucohydrolase Isoenzyme Exo1 In Complex With Gluco-Phenylimidazole |
| PDB | 3vnz_A | 0.0006 | 176 | 439 | 142 | 409 | A Chain A, Crystal Structure Of Barley Beta-D-Glucan Glucohydrolase Isoenzyme Exo1 In Complex With Gluco-Phenylimidazole |
| PDB | 3vny_A | 0.0006 | 176 | 439 | 142 | 409 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
