Basic Information | |
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Species | Cucumis sativus |
Cazyme ID | Cucsa.132500.1 |
Family | GH79 |
Protein Properties | Length: 540 Molecular Weight: 60318.8 Isoelectric Point: 7.3951 |
Chromosome | Chromosome/Scaffold: 01037 Start: 432199 End: 436028 |
Description | glucuronidase 3 |
View CDS |
External Links |
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NCBI Taxonomy |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH79 | 46 | 532 | 0 |
DEDFVCATLDWWPPEKCDYGTCSWGQASLLNLDLGNNILLNAVKEFKPLKLRLGGTLQDKIIYDTEDHQEPCIYLSKNTSELFGFSQGCLPTNRWDQLND FFKKGGAKIIFGLNALNGRQIAANGCSVGAWNYTNAEMLIRYTVKKNYTIHGWELGNELSGNGVGTRILAEQYASDTIVLQNMVQSIYKDIEPKPLIIAP GGFFDENWFKEFVGKTTPSLDVVTHHIYNLGPGVDEHLVEKILDPSYLDGMVDTFNKLHEILKNSPTSAKAWVGESGGAYNSGHNLVTNAFVFSFWYLDQ LGMAAAYDTKTYCRQTLIGGNYGLLNTTTFEPNPDYYSALLWHRLMGRNVLSTGFNGTEKIRAYAHCSKQSKGITLLLLNLDGNNTVHAGIAFNRTTALH HKHRSNKHKSNIVRIPRPRGLEGEAFREEYHLTAKDGNLHSQTVLLNGNILSVNSSGNIPPLEPQHVNSSEPIMVAPFSIVFIHIPN |
Full Sequence |
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Protein Sequence Length: 540 Download |
MGFRFWLLRF CFWVCFFFLC CGSVNSEGFL RGRVLIDGKS AIGRIDEDFV CATLDWWPPE 60 KCDYGTCSWG QASLLNLDLG NNILLNAVKE FKPLKLRLGG TLQDKIIYDT EDHQEPCIYL 120 SKNTSELFGF SQGCLPTNRW DQLNDFFKKG GAKIIFGLNA LNGRQIAANG CSVGAWNYTN 180 AEMLIRYTVK KNYTIHGWEL GNELSGNGVG TRILAEQYAS DTIVLQNMVQ SIYKDIEPKP 240 LIIAPGGFFD ENWFKEFVGK TTPSLDVVTH HIYNLGPGVD EHLVEKILDP SYLDGMVDTF 300 NKLHEILKNS PTSAKAWVGE SGGAYNSGHN LVTNAFVFSF WYLDQLGMAA AYDTKTYCRQ 360 TLIGGNYGLL NTTTFEPNPD YYSALLWHRL MGRNVLSTGF NGTEKIRAYA HCSKQSKGIT 420 LLLLNLDGNN TVHAGIAFNR TTALHHKHRS NKHKSNIVRI PRPRGLEGEA FREEYHLTAK 480 DGNLHSQTVL LNGNILSVNS SGNIPPLEPQ HVNSSEPIMV APFSIVFIHI PNIILPACR* 540 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03662 | Glyco_hydro_79n | 0 | 31 | 347 | 318 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
GO:0016798 | hydrolase activity, acting on glycosyl bonds |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CAN81917.1 | 0 | 1 | 539 | 1 | 555 | hypothetical protein [Vitis vinifera] |
EMBL | CBI25561.1 | 0 | 8 | 539 | 1 | 533 | unnamed protein product [Vitis vinifera] |
RefSeq | XP_002263173.1 | 0 | 1 | 539 | 5 | 559 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002324603.1 | 0 | 32 | 538 | 1 | 505 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002533671.1 | 0 | 1 | 539 | 1 | 551 | heparanase, putative [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3vo0_A | 0.0001 | 141 | 468 | 122 | 443 | A Chain A, Crystal Structure Of St2348, A Hypothetical Protein With Cbs Domains From Sulfolobus Tokodaii Strain7 |
PDB | 3vnz_A | 0.0001 | 141 | 468 | 122 | 443 | A Chain A, Crystal Structure Of St2348, A Hypothetical Protein With Cbs Domains From Sulfolobus Tokodaii Strain7 |
PDB | 3vny_A | 0.0001 | 141 | 468 | 122 | 443 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |