| Basic Information | |
|---|---|
| Species | Oryza sativa |
| Cazyme ID | LOC_Os06g08090.1 |
| Family | GH79 |
| Protein Properties | Length: 527 Molecular Weight: 56683.7 Isoelectric Point: 7.9799 |
| Chromosome | Chromosome/Scaffold: 6 Start: 3924681 End: 3927916 |
| Description | glucuronidase 3 |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GH79 | 41 | 520 | 0 |
| DEDFVCATMDWWPPDKCDYGTCSWGLASLLNLDLSNKILLNAIRGTFSPLKLRLGGSLQDKLVYGTGDGGGPCAPFVKNTSEMFGFTQGCLPLHRWDELN AFFQKSGARIVFGLNALNGRVPLPDGSMGGPWDYTNAASLIRYTASKGYKIHGWELGNELSGSGVGTKVGADQYAADVIALKSLVDTIYQGNPSKPLVLA PGGFFDAGWFTEVIVKTRPNLLNVVTHHIYNLGPGVDTHLIEKILNPSYLDGMVSTFSNLQGILKSAGTSAVAWVGESGGAYNSGRHLVTDSFVFSFWFL DQLGMSAKYDTKSYCRQSLIGGNYGLLNKETFQPNPDYYSALLWHRLMGTKVLSATFNGTNMIRTYAHCAKDSPGITLLLINLSGNTTSQVSVTSEGAHA NTVKKHSRKTRHLAAGSMREEYHLTAKDGSLQSQVMLLNGRALVADENGEIPRLEPVKVDAAQPIAVAPYSIVFAHIHNF | |||
| Full Sequence |
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| Protein Sequence Length: 527 Download |
| MEMRRFLGGL CFLALLRLGG AAEAVVGVAG VDGRRAIAAT DEDFVCATMD WWPPDKCDYG 60 TCSWGLASLL NLDLSNKILL NAIRGTFSPL KLRLGGSLQD KLVYGTGDGG GPCAPFVKNT 120 SEMFGFTQGC LPLHRWDELN AFFQKSGARI VFGLNALNGR VPLPDGSMGG PWDYTNAASL 180 IRYTASKGYK IHGWELGNEL SGSGVGTKVG ADQYAADVIA LKSLVDTIYQ GNPSKPLVLA 240 PGGFFDAGWF TEVIVKTRPN LLNVVTHHIY NLGPGVDTHL IEKILNPSYL DGMVSTFSNL 300 QGILKSAGTS AVAWVGESGG AYNSGRHLVT DSFVFSFWFL DQLGMSAKYD TKSYCRQSLI 360 GGNYGLLNKE TFQPNPDYYS ALLWHRLMGT KVLSATFNGT NMIRTYAHCA KDSPGITLLL 420 INLSGNTTSQ VSVTSEGAHA NTVKKHSRKT RHLAAGSMRE EYHLTAKDGS LQSQVMLLNG 480 RALVADENGE IPRLEPVKVD AAQPIAVAPY SIVFAHIHNF PAPACS* |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03662 | Glyco_hydro_79n | 0 | 40 | 344 | 305 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0005618 | cell wall |
| GO:0008150 | biological_process |
| GO:0008152 | metabolic process |
| GO:0016020 | membrane |
| GO:0016787 | hydrolase activity |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | ACF81144.1 | 0 | 32 | 526 | 35 | 543 | unknown [Zea mays] |
| GenBank | EAY99897.1 | 0 | 1 | 526 | 1 | 525 | hypothetical protein OsI_21892 [Oryza sativa Indica Group] |
| GenBank | EAZ36024.1 | 0 | 1 | 526 | 1 | 525 | hypothetical protein OsJ_20330 [Oryza sativa Japonica Group] |
| RefSeq | NP_001056967.1 | 0 | 1 | 526 | 1 | 526 | Os06g0179000 [Oryza sativa (japonica cultivar-group)] |
| RefSeq | NP_001132339.1 | 0 | 32 | 526 | 35 | 543 | hypothetical protein LOC100193781 [Zea mays] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3vo0_A | 0.0002 | 137 | 445 | 122 | 420 | A Chain A, Upf1-Rna Complex |
| PDB | 3vnz_A | 0.0002 | 137 | 445 | 122 | 420 | A Chain A, Upf1-Rna Complex |
| PDB | 3vny_A | 0.0002 | 137 | 445 | 122 | 420 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
