Basic Information | |
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Species | Panicum virgatum |
Cazyme ID | Pavirv00018674m |
Family | GH79 |
Protein Properties | Length: 432 Molecular Weight: 46890.7 Isoelectric Point: 6.5704 |
Chromosome | Chromosome/Scaffold: 047722 Start: 1773 End: 4705 |
Description | glucuronidase 3 |
View CDS |
External Links |
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CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH79 | 2 | 425 | 0 |
LIYDTGDSGQPCTPFVKNTSAMFGFSQGCLPLHRWDELNAFFQKSGAKIIFGLNALNGRVPMPDGSLGGPWNYTNAASFIRYTVNKGYDIHGWELGNELS GSGVGARIDADQYAADVINLKHIIDSTYQGNPSKPLVLAPGGFFDAAWFTELVSKTRAGQMDVITHHIYNLGPGVDDHLIEKILNPSYLDGEASTFSNLQ GILKSAGTSTVAWVGEAGGAYNSGHHLVTDAFVFSFWYLDQLGMSSKYDTKSYCRQTLVGGNYGLLNTTTFEPNPDYYSALLWHRLMGTTVLSATFNGTN KIRTYAHCAKNSEGITLLLINLSGNNTNSIYVTSNGAQTQSARKEGRRFSHIPGLGEAAELTREEYHLTPKDGNLQSQQVLLNGKVLATDANGDIPKLEP MQVEGTKPITVGPYSIVFAHIPSF |
Full Sequence |
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Protein Sequence Length: 432 Download |
MLIYDTGDSG QPCTPFVKNT SAMFGFSQGC LPLHRWDELN AFFQKSGAKI IFGLNALNGR 60 VPMPDGSLGG PWNYTNAASF IRYTVNKGYD IHGWELGNEL SGSGVGARID ADQYAADVIN 120 LKHIIDSTYQ GNPSKPLVLA PGGFFDAAWF TELVSKTRAG QMDVITHHIY NLGPGVDDHL 180 IEKILNPSYL DGEASTFSNL QGILKSAGTS TVAWVGEAGG AYNSGHHLVT DAFVFSFWYL 240 DQLGMSSKYD TKSYCRQTLV GGNYGLLNTT TFEPNPDYYS ALLWHRLMGT TVLSATFNGT 300 NKIRTYAHCA KNSEGITLLL INLSGNNTNS IYVTSNGAQT QSARKEGRRF SHIPGLGEAA 360 ELTREEYHLT PKDGNLQSQQ VLLNGKVLAT DANGDIPKLE PMQVEGTKPI TVGPYSIVFA 420 HIPSFYAPAC R* |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam12876 | Cellulase-like | 0.007 | 88 | 170 | 91 | + Sugar-binding cellulase-like. This is a putative cellulase family. | ||
pfam03662 | Glyco_hydro_79n | 3.0e-161 | 2 | 244 | 243 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
GO:0016798 | hydrolase activity, acting on glycosyl bonds |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
GenBank | EAY87898.1 | 0 | 1 | 431 | 110 | 541 | hypothetical protein OsI_09318 [Oryza sativa Indica Group] |
GenBank | EAY99897.1 | 0 | 2 | 430 | 101 | 524 | hypothetical protein OsI_21892 [Oryza sativa Indica Group] |
RefSeq | NP_001048420.1 | 0 | 1 | 431 | 110 | 541 | Os02g0802200 [Oryza sativa (japonica cultivar-group)] |
RefSeq | NP_001056967.1 | 0 | 2 | 430 | 102 | 525 | Os06g0179000 [Oryza sativa (japonica cultivar-group)] |
RefSeq | XP_002452991.1 | 0 | 1 | 430 | 110 | 539 | hypothetical protein SORBIDRAFT_04g036200 [Sorghum bicolor] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3vo0_A | 0.000004 | 37 | 321 | 122 | 395 | A Chain A, Elucidation Of The Substrate Specificity And Protein Structure Of Abfb, A Family 51 Alpha-L-Arabinofuranosidase From Bifidobacterium Longum. |
PDB | 3vnz_A | 0.000004 | 37 | 321 | 122 | 395 | A Chain A, Elucidation Of The Substrate Specificity And Protein Structure Of Abfb, A Family 51 Alpha-L-Arabinofuranosidase From Bifidobacterium Longum. |
PDB | 3vny_A | 0.000004 | 37 | 321 | 122 | 395 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
EST Download unfiltered results here | ||||
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Hit | Length | Start | End | EValue |
GO873156 | 326 | 87 | 409 | 0 |
JG950118 | 292 | 105 | 396 | 0 |
FL908740 | 227 | 39 | 265 | 0 |
GO873156 | 113 | 320 | 432 | 0.0000001 |
FL908740 | 36 | 243 | 278 | 6.6 |
Sequence Alignments (This image is cropped. Click for full image.) |
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