| Basic Information | |
|---|---|
| Species | Oryza sativa |
| Cazyme ID | LOC_Os06g08090.2 |
| Family | GH79 |
| Protein Properties | Length: 526 Molecular Weight: 56596.6 Isoelectric Point: 7.9799 |
| Chromosome | Chromosome/Scaffold: 6 Start: 3924681 End: 3927945 |
| Description | glucuronidase 3 |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GH79 | 41 | 519 | 0 |
| DEDFVCATMDWWPPDKCDYGTCSWGLASLLNLDLSNKILLNAIRAFSPLKLRLGGSLQDKLVYGTGDGGGPCAPFVKNTSEMFGFTQGCLPLHRWDELNA FFQKSGARIVFGLNALNGRVPLPDGSMGGPWDYTNAASLIRYTASKGYKIHGWELGNELSGSGVGTKVGADQYAADVIALKSLVDTIYQGNPSKPLVLAP GGFFDAGWFTEVIVKTRPNLLNVVTHHIYNLGPGVDTHLIEKILNPSYLDGMVSTFSNLQGILKSAGTSAVAWVGESGGAYNSGRHLVTDSFVFSFWFLD QLGMSAKYDTKSYCRQSLIGGNYGLLNKETFQPNPDYYSALLWHRLMGTKVLSATFNGTNMIRTYAHCAKDSPGITLLLINLSGNTTSQVSVTSEGAHAN TVKKHSRKTRHLAAGSMREEYHLTAKDGSLQSQVMLLNGRALVADENGEIPRLEPVKVDAAQPIAVAPYSIVFAHIHNF | |||
| Full Sequence |
|---|
| Protein Sequence Length: 526 Download |
| MEMRRFLGGL CFLALLRLGG AAEAVVGVAG VDGRRAIAAT DEDFVCATMD WWPPDKCDYG 60 TCSWGLASLL NLDLSNKILL NAIRAFSPLK LRLGGSLQDK LVYGTGDGGG PCAPFVKNTS 120 EMFGFTQGCL PLHRWDELNA FFQKSGARIV FGLNALNGRV PLPDGSMGGP WDYTNAASLI 180 RYTASKGYKI HGWELGNELS GSGVGTKVGA DQYAADVIAL KSLVDTIYQG NPSKPLVLAP 240 GGFFDAGWFT EVIVKTRPNL LNVVTHHIYN LGPGVDTHLI EKILNPSYLD GMVSTFSNLQ 300 GILKSAGTSA VAWVGESGGA YNSGRHLVTD SFVFSFWFLD QLGMSAKYDT KSYCRQSLIG 360 GNYGLLNKET FQPNPDYYSA LLWHRLMGTK VLSATFNGTN MIRTYAHCAK DSPGITLLLI 420 NLSGNTTSQV SVTSEGAHAN TVKKHSRKTR HLAAGSMREE YHLTAKDGSL QSQVMLLNGR 480 ALVADENGEI PRLEPVKVDA AQPIAVAPYS IVFAHIHNFP APACS* |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03662 | Glyco_hydro_79n | 0 | 40 | 343 | 304 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0005618 | cell wall |
| GO:0008150 | biological_process |
| GO:0008152 | metabolic process |
| GO:0016020 | membrane |
| GO:0016787 | hydrolase activity |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | ACF81144.1 | 0 | 32 | 525 | 35 | 543 | unknown [Zea mays] |
| GenBank | EAY99897.1 | 0 | 1 | 525 | 1 | 525 | hypothetical protein OsI_21892 [Oryza sativa Indica Group] |
| GenBank | EAZ36024.1 | 0 | 1 | 525 | 1 | 525 | hypothetical protein OsJ_20330 [Oryza sativa Japonica Group] |
| RefSeq | NP_001056967.1 | 0 | 1 | 525 | 1 | 526 | Os06g0179000 [Oryza sativa (japonica cultivar-group)] |
| RefSeq | NP_001132339.1 | 0 | 32 | 525 | 35 | 543 | hypothetical protein LOC100193781 [Zea mays] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3vo0_A | 0.0002 | 136 | 444 | 122 | 420 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
| PDB | 3vnz_A | 0.0002 | 136 | 444 | 122 | 420 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
| PDB | 3vny_A | 0.0002 | 136 | 444 | 122 | 420 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
