| Basic Information | |
|---|---|
| Species | Sorghum bicolor |
| Cazyme ID | Sb01g043180.1 |
| Family | GH79 |
| Protein Properties | Length: 544 Molecular Weight: 60579 Isoelectric Point: 8.5692 |
| Chromosome | Chromosome/Scaffold: 1 Start: 66449401 End: 66453951 |
| Description | glucuronidase 1 |
| View CDS | |
| External Links |
|---|
| NCBI Taxonomy |
| Plaza |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
 | |||
| Family | Start | End | Evalue |
| GH79 | 44 | 537 | 0 |
| DDNYVCATIDWWPPEKCNYNQCPWGQASILNLDLDHPFLAQAIQAFDHLRIRLGGSLQDRVVYDVGTESPCSPFTNASNGLFGFSVGCLGMDRWDKLNDL FQRTGALVTFGVNALYGRYNVRRSIWAGKWNSTNAYDFVKYTISKGYPVGSWEFGNELSGHGIGAKVDAKLYGKDVIEFKSILRQLYKAPLSQPLLLAPG GFFDQQWYSQLLETSGHGVVNALSHHVYNLGGGNDVHLIRKILDPKYLDRAEDTYRDMQLTIQRHGTWASAWVSESGGVFNNGGQLVSNTFINSIWYLDQ LGMASKYNTKVFCRQTLIGGNYGLLDTETFLPNPDYYSALLWHRLMGNGVLSVDINAPRQIRAYAHCRRQQQGITLLLINLSNTTGYNVTLQNDINVSLG KRPDLEKRSSFTHRLKKAVSWLGRKPTSDTKRREEYHLTAKDGDLQSKTMLLNGVPLELGDAGSIPAMDPVLVAVDSPVHLAPTSIAFVVLPKF | |||
| Full Sequence |
|---|
| Protein Sequence Length: 544 Download |
| MELRLRRLLL LALICLHAPR WASAQQPEEA TVIVKGSSRI AATDDNYVCA TIDWWPPEKC 60 NYNQCPWGQA SILNLDLDHP FLAQAIQAFD HLRIRLGGSL QDRVVYDVGT ESPCSPFTNA 120 SNGLFGFSVG CLGMDRWDKL NDLFQRTGAL VTFGVNALYG RYNVRRSIWA GKWNSTNAYD 180 FVKYTISKGY PVGSWEFGNE LSGHGIGAKV DAKLYGKDVI EFKSILRQLY KAPLSQPLLL 240 APGGFFDQQW YSQLLETSGH GVVNALSHHV YNLGGGNDVH LIRKILDPKY LDRAEDTYRD 300 MQLTIQRHGT WASAWVSESG GVFNNGGQLV SNTFINSIWY LDQLGMASKY NTKVFCRQTL 360 IGGNYGLLDT ETFLPNPDYY SALLWHRLMG NGVLSVDINA PRQIRAYAHC RRQQQGITLL 420 LINLSNTTGY NVTLQNDINV SLGKRPDLEK RSSFTHRLKK AVSWLGRKPT SDTKRREEYH 480 LTAKDGDLQS KTMLLNGVPL ELGDAGSIPA MDPVLVAVDS PVHLAPTSIA FVVLPKFEAK 540 ACS* |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
 | ||||||||
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03662 | Glyco_hydro_79n | 0 | 27 | 345 | 320 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | ACG44916.1 | 0 | 18 | 543 | 16 | 541 | heparanase-like protein 2 precursor [Zea mays] |
| GenBank | ACV84153.1 | 0 | 7 | 543 | 4 | 542 | heparanase [Oryza sativa Indica Group] |
| RefSeq | NP_001049350.1 | 0 | 7 | 543 | 4 | 541 | Os03g0211700 [Oryza sativa (japonica cultivar-group)] |
| RefSeq | NP_001145968.1 | 0 | 18 | 543 | 16 | 541 | hypothetical protein LOC100279495 [Zea mays] |
| RefSeq | XP_002468296.1 | 0 | 1 | 543 | 1 | 543 | hypothetical protein SORBIDRAFT_01g043180 [Sorghum bicolor] |
