| Basic Information | |
|---|---|
| Species | Citrus sinensis |
| Cazyme ID | orange1.1g008762m |
| Family | GH79 |
| Protein Properties | Length: 555 Molecular Weight: 60953.4 Isoelectric Point: 8.2891 |
| Chromosome | Chromosome/Scaffold: 00013 Start: 235167 End: 238283 |
| Description | glucuronidase 3 |
| View CDS | |
| External Links |
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| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
 | |||
| Family | Start | End | Evalue |
| GH79 | 58 | 547 | 0 |
| DDDFVCATLDWWPPEKCDYGTCSWDRASLLNLDLNSNILLNAVKAFSPLKIRLGGTLQDKVIYDTEDNRQPCKQFVKNSSEMFGFTQGCLPMHRWDELNA FFKKSGCPCIQFRAKIVFGLNALTGRSIQNDGSVKGAWDYTNAESFISYTVKKNYSIHGWELGNELCGNGVGTRVAAAQYATDTISLRNVVQKIYTGVDS KPLIIAPGGFFDAKWFKEFLDKSGQSLDVATHHIYNLGPGVDQHLVEKILDPLYLDREVDTFSQLENTLKSSATSAVAWVGESGGAYNSGHNLVTNAFVF SFWYLDQLGMAAAHDTKTYCRQSLIGGNYGLLNTTTFVPNPDYYSALLWHRLMGRNALSTSFSGTKKIRSYAHCAKQSKGLVLLLINLDNSTTVHASVAF NGTLTSRHKHKSLKMKIIKLPQASVGGNEREEYHLTAKDGDLHSQTMLLNGNILSVNSIGDIPTLEPLRVKSTQPVSVGPFSIVFVHMPH | |||
| Full Sequence |
|---|
| Protein Sequence Length: 555 Download |
| MGSQAWLKVL LFGFCFWLSS RSSSSSSLSI LQAEAAGGAG FVGGNVFIDR RSVIGRTDDD 60 FVCATLDWWP PEKCDYGTCS WDRASLLNLD LNSNILLNAV KAFSPLKIRL GGTLQDKVIY 120 DTEDNRQPCK QFVKNSSEMF GFTQGCLPMH RWDELNAFFK KSGCPCIQFR AKIVFGLNAL 180 TGRSIQNDGS VKGAWDYTNA ESFISYTVKK NYSIHGWELG NELCGNGVGT RVAAAQYATD 240 TISLRNVVQK IYTGVDSKPL IIAPGGFFDA KWFKEFLDKS GQSLDVATHH IYNLGPGVDQ 300 HLVEKILDPL YLDREVDTFS QLENTLKSSA TSAVAWVGES GGAYNSGHNL VTNAFVFSFW 360 YLDQLGMAAA HDTKTYCRQS LIGGNYGLLN TTTFVPNPDY YSALLWHRLM GRNALSTSFS 420 GTKKIRSYAH CAKQSKGLVL LLINLDNSTT VHASVAFNGT LTSRHKHKSL KMKIIKLPQA 480 SVGGNEREEY HLTAKDGDLH SQTMLLNGNI LSVNSIGDIP TLEPLRVKST QPVSVGPFSI 540 VFVHMPHVIL PACS* |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03662 | Glyco_hydro_79n | 0 | 46 | 366 | 322 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CAN81917.1 | 0 | 1 | 553 | 1 | 554 | hypothetical protein [Vitis vinifera] |
| EMBL | CBI25561.1 | 0 | 12 | 553 | 1 | 532 | unnamed protein product [Vitis vinifera] |
| RefSeq | XP_002263173.1 | 0 | 1 | 553 | 5 | 558 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002324603.1 | 0 | 44 | 554 | 1 | 506 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002533671.1 | 0 | 7 | 553 | 3 | 550 | heparanase, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3vo0_A | 0.0003 | 153 | 406 | 122 | 357 | A Chain A, Glu381ser Mutant Of Maize Cytokinin OxidaseDEHYDROGENASE COMPLEXED With N6-Isopentenyladenosine |
| PDB | 3vnz_A | 0.0003 | 153 | 406 | 122 | 357 | A Chain A, Glu381ser Mutant Of Maize Cytokinin OxidaseDEHYDROGENASE COMPLEXED With N6-Isopentenyladenosine |
| PDB | 3vny_A | 0.0003 | 153 | 406 | 122 | 357 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
