| Basic Information | |
|---|---|
| Species | Physcomitrella patens |
| Cazyme ID | Pp1s90_137V6.1 |
| Family | GH79 |
| Protein Properties | Length: 579 Molecular Weight: 63806.8 Isoelectric Point: 6.5658 |
| Chromosome | Chromosome/Scaffold: 90 Start: 876123 End: 879416 |
| Description | glucuronidase 3 |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| Plaza |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GH79 | 83 | 564 | 0 |
| DEHFLCATLDWWPPEKCDYGTCAWGNTSLLNVDLSNHLFEVALRDLSPLRIRLGGSLQDQVVYDIGDLQVECRPFEYNASHMFNFQGGCLSMERWTALLT LFNKTSTKVAFGLNALYNRPKLASGAWGPWDPSNAHDFIQYTIAQGFQVDAWQLGNELSGSGVRTSVPALQYAEDVTKLRDIVAVLHANTAKPLVIAPDG FFDYSWWEAFLKAAGPGSVNFTTRHIYNLGPGVSQDLVEKILNPQYLDGEKRTFGSVNELLQRVAPSTGAWIGEAGGAYNSGRHLVTDAFAFSFWYLDQL GMAASLNNKVYCRQSFIGGNYGLLNKTYQPNPDYFSALLWNRLMGTQVLMAKSGDNASHLRVYAHCTRDSNAQGGVTVLLINLSNTTTYEVEVSLTARTV TQYMKETFEGLVSIFTPSSERLEYHLTAPANDLHSQNMLLNGKLLQRSLTGQAPELTPLKVGSQTPINVSPLSITIAVIQNA | |||
| Full Sequence |
|---|
| Protein Sequence Length: 579 Download |
| MLWFLNPALS ALRIVLRDAD RFDTCTKMKI LLIPLIVSLL HLVVTLLVGI RYENPCHGSL 60 VCNDNVVSVK VEVNSSAAVA TVDEHFLCAT LDWWPPEKCD YGTCAWGNTS LLNVDLSNHL 120 FEVALRDLSP LRIRLGGSLQ DQVVYDIGDL QVECRPFEYN ASHMFNFQGG CLSMERWTAL 180 LTLFNKTSTK VAFGLNALYN RPKLASGAWG PWDPSNAHDF IQYTIAQGFQ VDAWQLGNEL 240 SGSGVRTSVP ALQYAEDVTK LRDIVAVLHA NTAKPLVIAP DGFFDYSWWE AFLKAAGPGS 300 VNFTTRHIYN LGPGVSQDLV EKILNPQYLD GEKRTFGSVN ELLQRVAPST GAWIGEAGGA 360 YNSGRHLVTD AFAFSFWYLD QLGMAASLNN KVYCRQSFIG GNYGLLNKTY QPNPDYFSAL 420 LWNRLMGTQV LMAKSGDNAS HLRVYAHCTR DSNAQGGVTV LLINLSNTTT YEVEVSLTAR 480 TVTQYMKETF EGLVSIFTPS SERLEYHLTA PANDLHSQNM LLNGKLLQRS LTGQAPELTP 540 LKVGSQTPIN VSPLSITIAV IQNAGLRFCK TLPAPFSN* |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03662 | Glyco_hydro_79n | 2.0e-147 | 81 | 383 | 305 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | EAY99897.1 | 0 | 73 | 575 | 31 | 522 | hypothetical protein OsI_21892 [Oryza sativa Indica Group] |
| RefSeq | NP_001056967.1 | 0 | 73 | 575 | 31 | 523 | Os06g0179000 [Oryza sativa (japonica cultivar-group)] |
| RefSeq | XP_001767170.1 | 0 | 1 | 578 | 1 | 544 | predicted protein [Physcomitrella patens subsp. patens] |
| RefSeq | XP_001769830.1 | 0 | 71 | 571 | 52 | 558 | predicted protein [Physcomitrella patens subsp. patens] |
| RefSeq | XP_001774747.1 | 0 | 64 | 569 | 13 | 523 | predicted protein [Physcomitrella patens subsp. patens] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3vo0_A | 0.0000006 | 180 | 479 | 124 | 410 | A Chain A, Structure And Mechanisim Of Core 2 Beta1,6-N- Acetylglucosaminyltransferase: A Metal-Ion Independent Gt-A Glycosyltransferase |
| PDB | 3vnz_A | 0.0000006 | 180 | 479 | 124 | 410 | A Chain A, Structure And Mechanisim Of Core 2 Beta1,6-N- Acetylglucosaminyltransferase: A Metal-Ion Independent Gt-A Glycosyltransferase |
| PDB | 3vny_A | 0.0000006 | 180 | 479 | 124 | 410 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
