| Basic Information | |
|---|---|
| Species | Mimulus guttatus |
| Cazyme ID | mgv1a026019m |
| Family | GH79 |
| Protein Properties | Length: 545 Molecular Weight: 59653.4 Isoelectric Point: 5.82 |
| Chromosome | Chromosome/Scaffold: 79 Start: 101072 End: 103688 |
| Description | glucuronidase 3 |
| View CDS | |
| External Links |
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| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GH79 | 46 | 537 | 0 |
| DEDFICATMDWWPPTKCDYGTCSWGTASLLNLDLSNKILVNAIRAFSPLKIRIGGTLQDKVIYQTADDPTPCSQFLRNSSEMFGFTQGCLPLSRWDDLNN FFNMTGAEIIFGLNALNGRTIGSDGSCTGAWNSSNAESLIRHTVNSGYTIYGWELGNELSGRGIGASVAAEQYASDIITLQKTVQDIYKGFETKPLVLGP GGFFDANWFTKFVKGAANSLQVLTHHIYNLGPGVDDHLIEKILDPSYLDGGAQPFRDLQKILNSSGSSTVAWVGEAGGAYNSGRDRVTNAFVFSFWYLDQ LGMSSSYDSKTYCRQSLIGGNYGLLDTNTYLPNPDYYSALLWHRLMGRNVLSTSFEGTKKIRAYAHCSKNSIGITLVLINLDKATTVEVGVSIENFISNK TLTVEQIVEQTRNTNPTSRYKHNGENEMMMREEYHLTAKDGDLHSQTMLLNGEIVKVNTSSGIIPPLVPRRVISSEPITVAPFSILFAQIPS | |||
| Full Sequence |
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| Protein Sequence Length: 545 Download |
| MASVLKIMGL SLWLYLASSQ GSTSSVFSEV NGTVHIDVSS SIGFTDEDFI CATMDWWPPT 60 KCDYGTCSWG TASLLNLDLS NKILVNAIRA FSPLKIRIGG TLQDKVIYQT ADDPTPCSQF 120 LRNSSEMFGF TQGCLPLSRW DDLNNFFNMT GAEIIFGLNA LNGRTIGSDG SCTGAWNSSN 180 AESLIRHTVN SGYTIYGWEL GNELSGRGIG ASVAAEQYAS DIITLQKTVQ DIYKGFETKP 240 LVLGPGGFFD ANWFTKFVKG AANSLQVLTH HIYNLGPGVD DHLIEKILDP SYLDGGAQPF 300 RDLQKILNSS GSSTVAWVGE AGGAYNSGRD RVTNAFVFSF WYLDQLGMSS SYDSKTYCRQ 360 SLIGGNYGLL DTNTYLPNPD YYSALLWHRL MGRNVLSTSF EGTKKIRAYA HCSKNSIGIT 420 LVLINLDKAT TVEVGVSIEN FISNKTLTVE QIVEQTRNTN PTSRYKHNGE NEMMMREEYH 480 LTAKDGDLHS QTMLLNGEIV KVNTSSGIIP PLVPRRVISS EPITVAPFSI LFAQIPSIQV 540 PACK* |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03662 | Glyco_hydro_79n | 0 | 29 | 347 | 320 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CBI25561.1 | 0 | 8 | 544 | 1 | 533 | unnamed protein product [Vitis vinifera] |
| RefSeq | XP_002263173.1 | 0 | 1 | 544 | 5 | 559 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002283254.1 | 0 | 1 | 543 | 1 | 536 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002283260.1 | 0 | 1 | 544 | 1 | 546 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002324878.1 | 0 | 32 | 543 | 1 | 504 | predicted protein [Populus trichocarpa] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3vo0_A | 0.000002 | 58 | 450 | 36 | 422 | A Chain A, The Structure Of A Protein In Glycosyl Transferase Family 8 From Anaerococcus Prevotii. |
| PDB | 3vnz_A | 0.000002 | 58 | 450 | 36 | 422 | A Chain A, The Structure Of A Protein In Glycosyl Transferase Family 8 From Anaerococcus Prevotii. |
| PDB | 3vny_A | 0.000002 | 58 | 450 | 36 | 422 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
