| Basic Information | |
|---|---|
| Species | Setaria italica |
| Cazyme ID | Si006147m |
| Family | GH79 |
| Protein Properties | Length: 573 Molecular Weight: 60910.5 Isoelectric Point: 9.7564 |
| Chromosome | Chromosome/Scaffold: 4 Start: 3999683 End: 4002907 |
| Description | glucuronidase 3 |
| View CDS | |
| External Links |
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| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GH79 | 49 | 565 | 0 |
| EDFVCATLDWWPPDKCDYGTCAWGRAGLLNLDLSNKVLLNAIRAFSPLKLRLGGSLQDKVVYGTADLGRPCTPFVKNASQMLGFTQGCLPLRRWDELNAF FQKSGAKVVFGLNALNGRVPLPDGSMGGPWDYTNAASLIRYTAYKGYQIHGWELGNELSGSGVGTRIGAGQYAADVIALRRIVDDIYRSNPSKPLVLAPG GFFEPGWFTELIVKTKPNLLNVITHHIYNLGPGRDTHLIEKILDPSVLDGMISTFSNLQGILKSTGTSTVAWVGEAGGAYNSGHHLVTDAFVFSFWFLDQ LGMSAKYDTKSYCRQSLIGGNYGLLNTTTFQPNPDYYSALLWHRLMGTKVLATTFTGTNKIRAYAHCARDSPGITLLLINLSGNTKTQVSVTQTAAVAGG AHNHGARRSNTTTQVSVTTQAAAAGEHKHGWRRHGRKFGHSHAPGLAAAAAAGATRDEYHLTPKGGDLRSQVMLLNGRALATGADGSIPRLEPVKVGAAE PIAVAPYSIVFARIPHF | |||
| Full Sequence |
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| Protein Sequence Length: 573 Download |
| MVAAGLRLLG VVWIFATLMP LGAAAAGAAG GHAAVAAVDG RRAVAATGED FVCATLDWWP 60 PDKCDYGTCA WGRAGLLNLD LSNKVLLNAI RAFSPLKLRL GGSLQDKVVY GTADLGRPCT 120 PFVKNASQML GFTQGCLPLR RWDELNAFFQ KSGAKVVFGL NALNGRVPLP DGSMGGPWDY 180 TNAASLIRYT AYKGYQIHGW ELGNELSGSG VGTRIGAGQY AADVIALRRI VDDIYRSNPS 240 KPLVLAPGGF FEPGWFTELI VKTKPNLLNV ITHHIYNLGP GRDTHLIEKI LDPSVLDGMI 300 STFSNLQGIL KSTGTSTVAW VGEAGGAYNS GHHLVTDAFV FSFWFLDQLG MSAKYDTKSY 360 CRQSLIGGNY GLLNTTTFQP NPDYYSALLW HRLMGTKVLA TTFTGTNKIR AYAHCARDSP 420 GITLLLINLS GNTKTQVSVT QTAAVAGGAH NHGARRSNTT TQVSVTTQAA AAGEHKHGWR 480 RHGRKFGHSH APGLAAAAAA GATRDEYHLT PKGGDLRSQV MLLNGRALAT GADGSIPRLE 540 PVKVGAAEPI AVAPYSIVFA RIPHFNAPAC RS* |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03662 | Glyco_hydro_79n | 0 | 47 | 350 | 304 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | ACF81144.1 | 0 | 39 | 570 | 35 | 542 | unknown [Zea mays] |
| GenBank | EAY99897.1 | 0 | 7 | 570 | 5 | 524 | hypothetical protein OsI_21892 [Oryza sativa Indica Group] |
| GenBank | EAZ36024.1 | 0 | 7 | 570 | 5 | 524 | hypothetical protein OsJ_20330 [Oryza sativa Japonica Group] |
| RefSeq | NP_001132339.1 | 0 | 39 | 570 | 35 | 542 | hypothetical protein LOC100193781 [Zea mays] |
| RefSeq | XP_002437942.1 | 0 | 1 | 570 | 1 | 553 | hypothetical protein SORBIDRAFT_10g005260 [Sorghum bicolor] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3vo0_A | 0.0000002 | 143 | 464 | 122 | 433 | A Chain A, Plant Carboxylesterase Aecxe1 From Actinidia Eriantha With Acyl Adduct |
| PDB | 3vnz_A | 0.0000002 | 143 | 464 | 122 | 433 | A Chain A, Plant Carboxylesterase Aecxe1 From Actinidia Eriantha With Acyl Adduct |
| PDB | 3vny_A | 0.0000002 | 143 | 464 | 122 | 433 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
