Basic Information | |
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Species | Mimulus guttatus |
Cazyme ID | mgv1a026758m |
Family | GH79 |
Protein Properties | Length: 504 Molecular Weight: 55912.5 Isoelectric Point: 7.1436 |
Chromosome | Chromosome/Scaffold: 37 Start: 956366 End: 958670 |
Description | glucuronidase 1 |
View CDS |
External Links |
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CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH79 | 18 | 496 | 0 |
DDNFICATLDWWPQNKCDYNQCPWAKSGILNLDLENKILTNAIKAFDHLRIRVGGSLQDQVIYRIGKPAKKCPHFKKQETGLFGFSKGCLHMDRWDQLNN LFNQTGAKITFGLNALIGRKQSSQDNSLMTGKWNHKNAHDFMKYTASKGFKIDSYELGNELCGSGVARRIEAEQYGKDMIVLKKLVQKLYPDPNTQPKVL GPGGFYDEEWFNTFLQTSGPNVVDGLTHHIYNLGAGVDPTLIDKIQDPFFLDQVAQTYKDVSTTVKLYGQWSGAWVGEAGGAYNSGGKSVSHTFVNGFWY LDQLGMTSTFNHKVFCRQALIGGNYALLNTTTFIPNPDYYGALLWHRLMGKNVLSATHDGSPYLRAYSHCSKKTAGISVLLINMSNSTTFEVSVVEDMNL YPNEETKSLEDISGDSNQREEYHLTPKDGNILSDVLLLNGTPLKLTESLEIPSMNPQLVDATLPITIAPDSIVFATLRG |
Full Sequence |
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Protein Sequence Length: 504 Download |
AEEVKLTVKG VNSIAKTDDN FICATLDWWP QNKCDYNQCP WAKSGILNLD LENKILTNAI 60 KAFDHLRIRV GGSLQDQVIY RIGKPAKKCP HFKKQETGLF GFSKGCLHMD RWDQLNNLFN 120 QTGAKITFGL NALIGRKQSS QDNSLMTGKW NHKNAHDFMK YTASKGFKID SYELGNELCG 180 SGVARRIEAE QYGKDMIVLK KLVQKLYPDP NTQPKVLGPG GFYDEEWFNT FLQTSGPNVV 240 DGLTHHIYNL GAGVDPTLID KIQDPFFLDQ VAQTYKDVST TVKLYGQWSG AWVGEAGGAY 300 NSGGKSVSHT FVNGFWYLDQ LGMTSTFNHK VFCRQALIGG NYALLNTTTF IPNPDYYGAL 360 LWHRLMGKNV LSATHDGSPY LRAYSHCSKK TAGISVLLIN MSNSTTFEVS VVEDMNLYPN 420 EETKSLEDIS GDSNQREEYH LTPKDGNILS DVLLLNGTPL KLTESLEIPS MNPQLVDATL 480 PITIAPDSIV FATLRGFKAP ACS* |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03662 | Glyco_hydro_79n | 0 | 1 | 322 | 322 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
GO:0016798 | hydrolase activity, acting on glycosyl bonds |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CBI27258.1 | 0 | 1 | 502 | 24 | 523 | unnamed protein product [Vitis vinifera] |
RefSeq | XP_002274743.1 | 0 | 1 | 502 | 22 | 521 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002315010.1 | 0 | 1 | 503 | 23 | 518 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002512114.1 | 0 | 1 | 501 | 28 | 529 | Heparanase precursor, putative [Ricinus communis] |
RefSeq | XP_002512114.1 | 0.000000000002 | 32 | 79 | 540 | 587 | Heparanase precursor, putative [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3vo0_A | 0.0001 | 68 | 385 | 75 | 383 | A Chain A, Structural Insights Into The Processivity Of Endopolygalacturonase I From Aspergillus Niger |
PDB | 3vnz_A | 0.0001 | 68 | 385 | 75 | 383 | A Chain A, Structural Insights Into The Processivity Of Endopolygalacturonase I From Aspergillus Niger |
PDB | 3vny_A | 0.0001 | 68 | 385 | 75 | 383 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
EST Download unfiltered results here | ||||
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Hit | Length | Start | End | EValue |
GR118344 | 261 | 75 | 335 | 0 |
JK986839 | 281 | 194 | 474 | 0 |
GR072627 | 268 | 219 | 486 | 0 |
AJ805815 | 236 | 178 | 413 | 0 |
GR196104 | 243 | 238 | 480 | 0 |
Sequence Alignments (This image is cropped. Click for full image.) |
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