Basic Information | |
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Species | Gossypium raimondii |
Cazyme ID | Gorai.N009200.1 |
Family | GH79 |
Protein Properties | Length: 501 Molecular Weight: 55165.6 Isoelectric Point: 7.1019 |
Chromosome | Chromosome/Scaffold: 20 Start: 80840 End: 83503 |
Description | glucuronidase 1 |
View CDS |
External Links |
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NCBI Taxonomy |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH79 | 41 | 200 | 3.19496e-43 |
DDNFVCATLDWWPTEKCNYNQCPWGKAGILNLDLKMKGLINAVKAFNPLRIKIGGSLQDQVVYGVGEVKNCPNFIKNEDSLFGFSQGCLPLERWDQLNNF FNQTGVKVIFGLNALLGRNRSEIEKGLWVGDWQSQNARDFMKYTISKGYKVDSHEFVKEL | |||
GH79 | 197 | 494 | 0 |
VKELHPDPKTQPKVLGPSGYYDEKWFNSFLEVSGHDVVDGVTHHIYNLGPGDDPNMIAKIQDPSYLNQVSQTYKGVLNIVNKFKPQSGAWVSESGGALHG GAKDLSPTFADGFWYLDQLGMASTYNQKVFCRQTLIGGNYALLNTTTSIPNPDYYGALLWHRLMGSTVLAVTQESNPNLRVYAHCAKKKPGISIIFINLS KDSSFNATLSNYEHQGRNLRSTDVVKPNFEFRGSKDREEYHLAALAGNIRGQIVLLNDVPMVPTETFDIPAVEPKLVNASTPIHIAAHSIVYVTIRDF |
Full Sequence |
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Protein Sequence Length: 501 Download |
MAVELVATRG VAVGLGQVAD ETCGGSTRCG ARGATPIAET DDNFVCATLD WWPTEKCNYN 60 QCPWGKAGIL NLDLKMKGLI NAVKAFNPLR IKIGGSLQDQ VVYGVGEVKN CPNFIKNEDS 120 LFGFSQGCLP LERWDQLNNF FNQTGVKVIF GLNALLGRNR SEIEKGLWVG DWQSQNARDF 180 MKYTISKGYK VDSHEFVKEL HPDPKTQPKV LGPSGYYDEK WFNSFLEVSG HDVVDGVTHH 240 IYNLGPGDDP NMIAKIQDPS YLNQVSQTYK GVLNIVNKFK PQSGAWVSES GGALHGGAKD 300 LSPTFADGFW YLDQLGMAST YNQKVFCRQT LIGGNYALLN TTTSIPNPDY YGALLWHRLM 360 GSTVLAVTQE SNPNLRVYAH CAKKKPGISI IFINLSKDSS FNATLSNYEH QGRNLRSTDV 420 VKPNFEFRGS KDREEYHLAA LAGNIRGQIV LLNDVPMVPT ETFDIPAVEP KLVNASTPIH 480 IAAHSIVYVT IRDFQAPACA * |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03662 | Glyco_hydro_79n | 5.0e-145 | 33 | 316 | 313 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
GO:0016798 | hydrolase activity, acting on glycosyl bonds |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CBI27258.1 | 0 | 33 | 499 | 33 | 523 | unnamed protein product [Vitis vinifera] |
RefSeq | XP_002274743.1 | 0 | 33 | 499 | 31 | 521 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002315010.1 | 0 | 31 | 500 | 30 | 518 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002512114.1 | 0 | 32 | 498 | 36 | 529 | Heparanase precursor, putative [Ricinus communis] |
RefSeq | XP_002512114.1 | 0.0000000000005 | 34 | 102 | 507 | 587 | Heparanase precursor, putative [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3vo0_A | 0.0000003 | 132 | 398 | 119 | 403 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
PDB | 3vnz_A | 0.0000003 | 132 | 398 | 119 | 403 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
PDB | 3vny_A | 0.0000003 | 132 | 398 | 119 | 403 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
EST Download unfiltered results here | ||||
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Hit | Length | Start | End | EValue |
GO873410 | 322 | 39 | 332 | 0 |
JK986839 | 276 | 196 | 471 | 0 |
CK266509 | 313 | 85 | 368 | 0 |
GO875320 | 331 | 105 | 407 | 0 |
GR072627 | 267 | 213 | 479 | 0 |
Sequence Alignments (This image is cropped. Click for full image.) |
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