| PULID | Characterization Method(s) | Substrate | Organism | Publication | Publish Date | Type | Num Genes | Num CAZymes | CazyFamily |
|---|---|---|---|---|---|---|---|---|---|
| PUL0009 | enzyme activity assay, immunoblotting, ATPase assay | glycosaminoglycan | Streptobacillus moniliformis | 28432302 A bacterial ABC transporter enables import of mammalian host glycosaminoglycans. Sci Rep. 2017 Apr 21;7(1):1069. doi: 10.1038/s41598-017-00917-y. |
2017 Apr 21 | degradation | 15 | 4 | PL8, PL8, GH88 |
| PUL0018 | rapid plate method growth assay, gene deletion mutant and growth assay, RT-PCR, enzyme activity assay | glycosaminoglycan | Streptococcus pneumoniae | 22311922 Streptococcus pneumoniae can utilize multiple sources of hyaluronic acid for growth. Infect Immun. 2012 Apr;80(4):1390-8. doi: 10.1128/IAI.05756-11. Epub 2012 Feb 6. |
2012 Apr | degradation | 12 | 3 | CBM70, PL8_1, PL8, GH88, PL12_1 |
| PUL0020 | rapid plate method growth assay, adhesion assay | glycosaminoglycan | Lactobacillus rhamnosus | 30006634 Probiotics in human gut microbiota can degrade host glycosaminoglycans. Sci Rep. 2018 Jul 13;8(1):10674. doi: 10.1038/s41598-018-28886-w. |
2018 Jul 13 | degradation | 16 | 3 | PL12_1, PL12, GH88, PL8 |
| PUL0021 | rapid plate method growth assay, adhesion assay | glycosaminoglycan | Lactobacillus casei | 30006634 Probiotics in human gut microbiota can degrade host glycosaminoglycans. Sci Rep. 2018 Jul 13;8(1):10674. doi: 10.1038/s41598-018-28886-w. |
2018 Jul 13 | degradation | 16 | 2 | PL12, PL12_1, GH88 |
| PUL0145 | enzyme activity assay | glycosaminoglycan, chondroitin sulfate | Bacteroides thetaiotaomicron | 30262663 The human gut microbe Bacteroides thetaiotaomicron encodes the founding member of a novel glycosaminoglycan-degrading polysaccharide lyase family PL29. J Biol Chem. 2018 Nov 16;293(46):17906-17916. doi: 10.1074/jbc.RA118.004510. Epub 2018 Sep 27. |
2018 Nov 16 | degradation | 27 | 5 | PL8, PL8_2, PL29, GH2, GH88, PL8_2 |
| PUL0207 | enzyme activity assay | N-glycan | Streptococcus agalactiae | 25605731 Metabolic fate of unsaturated glucuronic/iduronic acids from glycosaminoglycans: molecular identification and structure determination of streptococcal isomerase and dehydrogenase. J Biol Chem. 2015 Mar 6;290(10):6281-92. doi: 10.1074/jbc.M114.604546. Epub 2015 Jan 20. |
2015 Mar 6 | degradation | 7 | 2 | PL12, PL12_1, GH88 |
| PUL0210 | enzyme activity assay | N-glycan | Clostridium perfringens | 25605731 Metabolic fate of unsaturated glucuronic/iduronic acids from glycosaminoglycans: molecular identification and structure determination of streptococcal isomerase and dehydrogenase. J Biol Chem. 2015 Mar 6;290(10):6281-92. doi: 10.1074/jbc.M114.604546. Epub 2015 Jan 20. |
2015 Mar 6 | degradation | 13 | 3 | PL8, GH88, PL12_1 |
| PUL0369 | RT-PCR | unsaturated hyaluronate disaccharide, chondroitin disaccharide | Streptococcus agalactiae NEM316 | 19416976 Substrate specificity of streptococcal unsaturated glucuronyl hydrolases for sulfated glycosaminoglycan. J Biol Chem. 2009 Jul 3;284(27):18059-69. doi: 10.1074/jbc.M109.005660. Epub 2009 May 5. |
2009 Jul 3 | degradation | 11 | 1 | GH88 |
| PUL0377 | microarray, qPCR | glycosaminoglycan | Bacteroides thetaiotaomicron | 18996345 Mucosal glycan foraging enhances fitness and transmission of a saccharolytic human gut bacterial symbiont. Cell Host Microbe. 2008 Nov 13;4(5):447-57. doi: 10.1016/j.chom.2008.09.007. |
2008 Nov 13 | degradation | 27 | 3 | PL8_2, PL8, PL29, GH2, GH88, PL8_2 |
| PUL0384 | microarray, qPCR | glycosaminoglycan | Bacteroides thetaiotaomicron | 18996345 Mucosal glycan foraging enhances fitness and transmission of a saccharolytic human gut bacterial symbiont. Cell Host Microbe. 2008 Nov 13;4(5):447-57. doi: 10.1016/j.chom.2008.09.007. |
2008 Nov 13 | degradation | 12 | 3 | PL15_2, PL15, PL12, PL12_2, GH88, PL12_2 |
| PUL0543 | RNA-Seq | cellobiose, beta-glucan, glucosamine | Bacteroides cellulosilyticus | 23976882 Effects of diet on resource utilization by a model human gut microbiota containing Bacteroides cellulosilyticus WH2, a symbiont with an extensive glycobiome. PLoS Biol. 2013;11(8):e1001637. doi: 10.1371/journal.pbio.1001637. Epub 2013 Aug 20. |
2013 | degradation | 6 | 3 | GH30, GH30_3, GH2, CBM57, GH88 |
| PUL0555 | gene deletion mutant and growth assay, qRT-PCR, microarray, enzyme activity assay | N-glycan | Bacteroides fragilis | 25139987 Efficient utilization of complex N-linked glycans is a selective advantage for Bacteroides fragilis in extraintestinal infections. Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12901-6. doi: 10.1073/pnas.1407344111. Epub 2014 Aug 19. |
2014 Sep 2 | degradation | 9 | 5 | GH154, GH2, GH20, GH88, PL0, PL33_1 |
| PUL0613 | RNA-Seq | O-glycan, N-glycan | Prevotella sp. PINT | 33113351 Distinct Polysaccharide Utilization Determines Interspecies Competition between Intestinal Prevotella spp. Cell Host Microbe. 2020 Dec 9;28(6):838-852.e6. doi: 10.1016/j.chom.2020.09.012. Epub 2020 Oct 27. |
2020 Dec 9 | degradation | 5 | 2 | PL38, GH88, GH2, CBM57 |
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