Basic Information | |
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Species | Arabidopsis lyrata |
Cazyme ID | 326421 |
Family | GT47 |
Protein Properties | Length: 655 Molecular Weight: 75292.5 Isoelectric Point: 9.3775 |
Chromosome | Chromosome/Scaffold: 6 Start: 8571406 End: 8577580 |
Description | Exostosin family protein |
View CDS |
External Links |
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NCBI Taxonomy |
Plaza |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GT47 | 321 | 605 | 0 |
EKKFKVWVYREGDTPLVHMGPVNNIYSIEGQFMDEIETGMSPFAASGPEEAHAFLLPVSIANVVHYLYRPLVTYSREQLHKVFLDYVNVVAHKYPYWNRS LGADHFFVSCHDWAPDVSGSNPEMMKNLIRVLCNANTSEGFMPQRDVSIPEINIPRGQLGPPQLSRSSGHDRPILAFFSGGSHGYIRKILLQHWKDKDEE VQVHEYLTNNKDYFKLMATARFCLCPSGYEVASPRVVAAINLGCVPVIISDHYALPFSDVLDWTKFTIHVPSEKIPEIKTILKSI |
Full Sequence |
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Protein Sequence Length: 655 Download |
MKDNEYILNY YRADWSIRDA FFSVFSFHNE SLNVWTHLIG FILFVALTVA NIIHHDGFFP 60 VDAKSPGNVT RWPFFVFLGG SMFCLLASSI CHLFCCHSKD LNVFLLRIDY AGITAMIITS 120 FFPPIFYIFQ CTPRWYFIYL AGITSMGIFT IITLFTPSLS APKYRAFRAL LFASMGLFGI 180 VPAVHALVVN WGNPQRNVTL VYELLMAVFY LVGTGFYVGR VPERLKPGWF DRVGHSHQIF 240 HVFVLLGALS HYAAALLFLD WRDHKEKKRN RIEEGLAKSR AAIREAVRLK KFASDKEETS 300 VPRGAVYRNA FAFHQSHMEM EKKFKVWVYR EGDTPLVHMG PVNNIYSIEG QFMDEIETGM 360 SPFAASGPEE AHAFLLPVSI ANVVHYLYRP LVTYSREQLH KVFLDYVNVV AHKYPYWNRS 420 LGADHFFVSC HDWAPDVSGS NPEMMKNLIR VLCNANTSEG FMPQRDVSIP EINIPRGQLG 480 PPQLSRSSGH DRPILAFFSG GSHGYIRKIL LQHWKDKDEE VQVHEYLTNN KDYFKLMATA 540 RFCLCPSGYE VASPRVVAAI NLGCVPVIIS DHYALPFSDV LDWTKFTIHV PSEKIPEIKT 600 ILKSISWRRY KVLQRRVLQV QRHFVINRPS QPFDMLRMLL HSVWLRRLNL RLPL* 660 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
TIGR01065 | hlyIII | 3.0e-13 | 29 | 259 | 233 | + channel protein, hemolysin III family. This family includes proteins from pathogenic and non-pathogenic bacteria, Homo sapiens and Drosophila. In Bacillus cereus, a pathogen, it has been show to function as a channel-forming cytolysin. The human protein is expressed preferentially in mature macrophages, consistent with a role cytolytic role. | ||
COG1272 | COG1272 | 1.0e-32 | 1 | 262 | 264 | + Predicted membrane protein, hemolysin III homolog [General function prediction only] | ||
pfam03006 | HlyIII | 9.0e-53 | 25 | 252 | 229 | + Haemolysin-III related. Members of this family are integral membrane proteins. This family includes a protein with hemolytic activity from Bacillus cereus. It has been proposed that YOL002c encodes a Saccharomyces cerevisiae protein that plays a key role in metabolic pathways that regulate lipid and phosphate metabolism. In eukaryotes, members are seven-transmembrane pass molecules found to encode functional receptors with a broad range of apparent ligand specificities, including progestin and adipoQ receptors, and hence have been named PAQR proteins. The mammalian members include progesterone binding proteins. Unlike the case with GPCR receptor proteins, the evolutionary ancestry of the members of this family can be traced back to the Archaea. | ||
pfam03016 | Exostosin | 7.0e-62 | 320 | 605 | 304 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
GO:0016021 | integral to membrane |