| Basic Information | |
|---|---|
| Species | Thellungiella halophila |
| Cazyme ID | Thhalv10011359m |
| Family | GT68 |
| Protein Properties | Length: 560 Molecular Weight: 63676.7 Isoelectric Point: 7.8635 |
| Chromosome | Chromosome/Scaffold: 7 Start: 841178 End: 843313 |
| Description | O-fucosyltransferase family protein |
| View CDS | |
| External Links |
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| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GT68 | 235 | 537 | 0 |
| KRILVIPSHRFDYHYSRIIDIDRINTCLGRNVVVSFEEFWKKDKNRKKHHHVHINRFICYFSKPEPCYVDKEHITKLKALGITIGGKLDTPWEEDIARPS NKTAEEVETNFRSDDDVIAIGDVFYANVEREWVMQPGGPIAHKCQTLIEPNRLISLTAQRFIQTFLGKNYIALHFRRHGFLKFCNAKNPSCFYPIPQAAN CITRLIEKVEAPVIYLSTDAAESETGLLQSLLMLNGKTVPLVKRPARDSAEKWDALLYRHGLEGDSQVEAMLDKTICAVSSVFIGASGSTFTEDILRLRK DWG | |||
| Full Sequence |
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| Protein Sequence Length: 560 Download |
| MERDSSSTSS SSSSSLDESD SQIHRFRGSD EIPLSYSDAA EQRPTFDVES LRSRLTRSFK 60 LNITKRQFIV IFLPLVLVFL YLSTDFSNYF FSVKVPDSVF RPITGTGRAQ ESDLQALYLL 120 RKQEIDLFSI WNHTLSNLST IEDVKSAVFR QISLNRQIQN ALLSPHKTGN VSIDGSSDGL 180 PVGSCRKVDQ KLTGRKTIQW KPRPDKFLFA ICLSGQMSNH LICLEKHMFF AALLKRILVI 240 PSHRFDYHYS RIIDIDRINT CLGRNVVVSF EEFWKKDKNR KKHHHVHINR FICYFSKPEP 300 CYVDKEHITK LKALGITIGG KLDTPWEEDI ARPSNKTAEE VETNFRSDDD VIAIGDVFYA 360 NVEREWVMQP GGPIAHKCQT LIEPNRLISL TAQRFIQTFL GKNYIALHFR RHGFLKFCNA 420 KNPSCFYPIP QAANCITRLI EKVEAPVIYL STDAAESETG LLQSLLMLNG KTVPLVKRPA 480 RDSAEKWDAL LYRHGLEGDS QVEAMLDKTI CAVSSVFIGA SGSTFTEDIL RLRKDWGTAS 540 DCDEYLCQNE QPNFVADHE* |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| cd11296 | O-FucT_like | 0.0005 | 207 | 248 | 42 | + GDP-fucose protein O-fucosyltransferase and related proteins. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes. | ||
| pfam10250 | O-FucT | 0.0005 | 230 | 526 | 326 | + GDP-fucose protein O-fucosyltransferase. This is a family of conserved proteins representing the enzyme responsible for adding O-fucose to EGF (epidermal growth factor-like) repeats. Six highly conserved cysteines are present in O-FucT-1 as well as a DXD-like motif (ERD), conserved in mammals, Drosophila, and C. elegans. Both features are characteristic of several glycosyltransferase families. The enzyme is a membrane-bound protein released by proteolysis and, as for most glycosyltransferases, is strongly activated by manganese. | ||
| cd11298 | O-FucT-2 | 1.0e-8 | 386 | 526 | 141 | + GDP-fucose protein O-fucosyltransferase 2. O-FucT-2 adds O-fucose to thrombospondin type 1 repeats (TSRs), and appears conserved in bilateria. The O-fucosylation of TSRs appears to play a role in regulating secretion of metalloproteases of the ADAMTS superfamily. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes. | ||
| cd11296 | O-FucT_like | 8.0e-17 | 375 | 533 | 169 | + GDP-fucose protein O-fucosyltransferase and related proteins. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes. | ||
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| DDBJ | BAF00786.1 | 0 | 16 | 559 | 27 | 563 | hypothetical protein [Arabidopsis thaliana] |
| RefSeq | NP_173170.2 | 0 | 43 | 559 | 46 | 564 | unknown protein [Arabidopsis thaliana] |
| RefSeq | NP_175780.1 | 0 | 16 | 559 | 27 | 563 | unknown protein [Arabidopsis thaliana] |
| RefSeq | NP_199853.1 | 0 | 1 | 559 | 1 | 566 | unknown protein [Arabidopsis thaliana] |
| RefSeq | XP_002264087.1 | 0 | 1 | 559 | 1 | 559 | PREDICTED: hypothetical protein [Vitis vinifera] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 4ap6_D | 0.004 | 400 | 526 | 277 | 383 | A Chain A, Crystal Structure Of Human Pofut2 E54a Mutant In Complex With Gdp- Fucose |
| PDB | 4ap6_C | 0.004 | 400 | 526 | 277 | 383 | A Chain A, Crystal Structure Of Human Pofut2 E54a Mutant In Complex With Gdp- Fucose |
| PDB | 4ap6_B | 0.004 | 400 | 526 | 277 | 383 | A Chain A, Crystal Structure Of Human Pofut2 E54a Mutant In Complex With Gdp- Fucose |
| PDB | 4ap6_A | 0.004 | 400 | 526 | 277 | 383 | A Chain A, Crystal Structure Of Human Pofut2 E54a Mutant In Complex With Gdp- Fucose |
| PDB | 4ap5_B | 0.005 | 400 | 526 | 263 | 369 | A Chain A, Crystal Structure Of Human Pofut2 |
