| Basic Information | |
|---|---|
| Species | Malus domestica |
| Cazyme ID | MDP0000212192 |
| Family | GT41 |
| Protein Properties | Length: 567 Molecular Weight: 62563.4 Isoelectric Point: 6.1012 |
| Chromosome | Chromosome/Scaffold: 016913157 Start: 76 End: 5350 |
| Description | Tetratricopeptide repeat (TPR)-like superfamily protein |
| View CDS | |
| External Links |
|---|
| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GT41 | 16 | 504 | 0 |
| QGKMDAAANMIDKAIVANPTYAEAYNNLGVLYRDAGNITLAIGAYEECLKIDPDSRNAGQFFSLGNVFNALGLLANRLLAMNYINEGHDDKLFVAHRDWG RRFXRLYPQYTSWDNPKDPERPLIIGYVSPDYFTHSVSYFIEAPLAHHEYTKYKVVVYSAVVKADAKTIRFREKVLKKGGIWRDIYGIDEKKVASIIRED KVDILVELTGHTANNKLGTMACRPSPVQVTWIGYPNTTGLPAIDYRITDSLADPPDSKQTHVEDLVRLPDCFLCYTPSPEAGPVMPTPALSNGFVTFGSF NNLAKITPKVLQVWARILSAIPNSRLVVKCKPFSCDSVRERFLSTLEQLGLEPLRVDLLPLILLNYDHMQAYSLMXISLDTFPYAGTTTTCESLYMGVPC VTMAGSVHAHNVGVSILSKVGLGNLIAKNEDEYVQLAVQLASDVTALSNLRMGLRDLMARSPVCDGPKFTSGXESAYRSMWHRYCKGDV | |||
| Full Sequence |
|---|
| Protein Sequence Length: 567 Download |
| MAIHQIVADC PLCYWQGKMD AAANMIDKAI VANPTYAEAY NNLGVLYRDA GNITLAIGAY 60 EECLKIDPDS RNAGQFFSLG NVFNALGLLA NRLLAMNYIN EGHDDKLFVA HRDWGRRFXR 120 LYPQYTSWDN PKDPERPLII GYVSPDYFTH SVSYFIEAPL AHHEYTKYKV VVYSAVVKAD 180 AKTIRFREKV LKKGGIWRDI YGIDEKKVAS IIREDKVDIL VELTGHTANN KLGTMACRPS 240 PVQVTWIGYP NTTGLPAIDY RITDSLADPP DSKQTHVEDL VRLPDCFLCY TPSPEAGPVM 300 PTPALSNGFV TFGSFNNLAK ITPKVLQVWA RILSAIPNSR LVVKCKPFSC DSVRERFLST 360 LEQLGLEPLR VDLLPLILLN YDHMQAYSLM XISLDTFPYA GTTTTCESLY MGVPCVTMAG 420 SVHAHNVGVS ILSKVGLGNL IAKNEDEYVQ LAVQLASDVT ALSNLRMGLR DLMARSPVCD 480 GPKFTSGXES AYRSMWHRYC KGDVPSQRQM EMLQEEVIAE DPAAGISDPT SITTPXEGPP 540 GSIKTNGFGP VPXPALNPSA CEENGGV 600 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| cd00189 | TPR | 2.0e-12 | 12 | 83 | 72 | + Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans in various subcellular locations; involved in a variety of functions including protein-protein interactions, but common features in the interaction partners have not been defined; involved in chaperone, cell-cycle, transciption, and protein transport complexes; the number of TPR motifs varies among proteins (1,3-11,13 15,16,19); 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accomodate an alpha-helix of a target protein; it has been proposed that TPR proteins preferably interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes; examples of TPR-proteins include, Cdc16p, Cdc23p and Cdc27p components of the cyclosome/APC, the Pex5p/Pas10p receptor for peroxisomal targeting signals, the Tom70p co-receptor for mitochondrial targeting signals, Ser/Thr phosphatase 5C and the p110 subunit of O-GlcNAc transferase; three copies of the repeat are present here | ||
| pfam13844 | Glyco_transf_41 | 7.0e-15 | 138 | 287 | 153 | + Glycosyl transferase family 41. This family of glycosyltransferases includes O-linked beta-N-acetylglucosamine (O-GlcNAc) transferase, an enzyme which catalyzes the addition of O-GlcNAc to serine and threonine residues. In addition to its function as an O-GlcNAc transferase, human OGT, also appears to proteolytically cleave the epigenetic cell-cycle regulator HCF-1. | ||
| pfam13844 | Glyco_transf_41 | 2.0e-19 | 310 | 496 | 187 | + Glycosyl transferase family 41. This family of glycosyltransferases includes O-linked beta-N-acetylglucosamine (O-GlcNAc) transferase, an enzyme which catalyzes the addition of O-GlcNAc to serine and threonine residues. In addition to its function as an O-GlcNAc transferase, human OGT, also appears to proteolytically cleave the epigenetic cell-cycle regulator HCF-1. | ||
| COG3914 | Spy | 4.0e-80 | 123 | 499 | 384 | + Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones] | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0005515 | protein binding |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CAX46402.1 | 0 | 16 | 565 | 383 | 915 | putative SPINDLY protein [Rosa luciae] |
| EMBL | CAX46402.1 | 0.0006 | 18 | 69 | 208 | 259 | putative SPINDLY protein [Rosa luciae] |
| RefSeq | XP_002281883.1 | 0 | 16 | 565 | 379 | 912 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002281883.1 | 0.001 | 18 | 102 | 204 | 283 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002308458.1 | 0 | 16 | 564 | 381 | 920 | predicted protein [Populus trichocarpa] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 2vsn_B | 7e-30 | 137 | 465 | 205 | 529 | A Chain A, Structure And Topological Arrangement Of An O-Glcnac Transferase Homolog: Insight Into Molecular Control Of Intracellular Glycosylation |
| PDB | 2vsn_A | 7e-30 | 137 | 465 | 205 | 529 | A Chain A, Structure And Topological Arrangement Of An O-Glcnac Transferase Homolog: Insight Into Molecular Control Of Intracellular Glycosylation |
| PDB | 2xgs_B | 9e-30 | 137 | 465 | 205 | 529 | A Chain A, Structure And Topological Arrangement Of An O-Glcnac Transferase Homolog: Insight Into Molecular Control Of Intracellular Glycosylation |
| PDB | 2xgs_A | 9e-30 | 137 | 465 | 205 | 529 | A Chain A, Structure And Topological Arrangement Of An O-Glcnac Transferase Homolog: Insight Into Molecular Control Of Intracellular Glycosylation |
| PDB | 2xgo_B | 9e-30 | 137 | 465 | 205 | 529 | A Chain A, Structure And Topological Arrangement Of An O-Glcnac Transferase Homolog: Insight Into Molecular Control Of Intracellular Glycosylation |
| Hydropathy |
|---|
 |
| EST Download unfiltered results here | ||||
|---|---|---|---|---|
| Hit | Length | Start | End | EValue |
| DY295408 | 416 | 65 | 477 | 0 |
| HO781209 | 361 | 143 | 503 | 0 |
| HO781209 | 134 | 28 | 161 | 0 |
| GO856896 | 300 | 217 | 516 | 0 |
| FC900541 | 299 | 65 | 363 | 0 |
| Sequence Alignments (This image is cropped. Click for full image.) |
|---|
 |
