| Basic Information | |
|---|---|
| Species | Citrus clementina |
| Cazyme ID | Ciclev10028463m |
| Family | GH29 |
| Protein Properties | Length: 443 Molecular Weight: 49666.4 Isoelectric Point: 6.6299 |
| Chromosome | Chromosome/Scaffold: 8 Start: 21357003 End: 21359868 |
| Description | alpha-L-fucosidase 1 |
| View CDS | |
| External Links |
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| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GH29 | 194 | 266 | 6.9e-22 |
| DPHGHDWVPAECDVSIRRGWFWHASEAPKSAVELLDLYYKSVGRNCLLLLNVPPNSSGLISAEDIQVLQEFSD | |||
| GH29 | 51 | 191 | 0 |
| EWQLSSMALFLHFGPNTFTDSEWGTGRADPRVFNPTRLNASQWVHAAKSAGFNRVILTAKHHDGFCLWPSEYTDYSVKSSEWKNGTGDVVAELALAAKEA GVDLGLYLSPWDRHEPSYGKTLEYNEFYMAQMAELLTRYSQ | |||
| Full Sequence |
|---|
| Protein Sequence Length: 443 Download |
| MKKNKNNCTK PISQNLILTL LALYFIPISN SPLKKPPPLP ILPLPSSPQL EWQLSSMALF 60 LHFGPNTFTD SEWGTGRADP RVFNPTRLNA SQWVHAAKSA GFNRVILTAK HHDGFCLWPS 120 EYTDYSVKSS EWKNGTGDVV AELALAAKEA GVDLGLYLSP WDRHEPSYGK TLEYNEFYMA 180 QMAELLTRYS QGGDPHGHDW VPAECDVSIR RGWFWHASEA PKSAVELLDL YYKSVGRNCL 240 LLLNVPPNSS GLISAEDIQV LQEFSDLRKS IFSYNLAENA LVSASSTRGG ISSSQFDPHN 300 VMKEGIYTYW APEENQSDWT LLINLQEPVS FNVLQVQEPI HMGQRIIKFH LDILNEEGTW 360 KKVINGTTVG YQRLLQFPTV KSQQLRFVID KSRAEPLISH SGIYMDKFSI VSSMSDSTSQ 420 TSLNGSHILQ KSMFNHSEIA AI* |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| smart00812 | Alpha_L_fucos | 0.0007 | 193 | 264 | 75 | + Alpha-L-fucosidase. O-Glycosyl hydrolases (EC 3.2.1.-) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site. Because the fold of proteins is better conserved than their sequences, some of the families can be grouped in 'clans'. Family 29 encompasses alpha-L-fucosidases, which is a lysosomal enzyme responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. Deficiency of alpha-L-fucosidase results in the lysosomal storage disease fucosidosis. | ||
| COG3669 | COG3669 | 3.0e-12 | 174 | 404 | 233 | + Alpha-L-fucosidase [Carbohydrate transport and metabolism] | ||
| smart00812 | Alpha_L_fucos | 4.0e-19 | 83 | 189 | 121 | + Alpha-L-fucosidase. O-Glycosyl hydrolases (EC 3.2.1.-) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site. Because the fold of proteins is better conserved than their sequences, some of the families can be grouped in 'clans'. Family 29 encompasses alpha-L-fucosidases, which is a lysosomal enzyme responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. Deficiency of alpha-L-fucosidase results in the lysosomal storage disease fucosidosis. | ||
| pfam01120 | Alpha_L_fucos | 3.0e-21 | 51 | 264 | 281 | + Alpha-L-fucosidase. | ||
| COG3669 | COG3669 | 8.0e-31 | 51 | 201 | 161 | + Alpha-L-fucosidase [Carbohydrate transport and metabolism] | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0004560 | alpha-L-fucosidase activity |
| GO:0005975 | carbohydrate metabolic process |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| RefSeq | XP_002276131.1 | 0 | 189 | 442 | 273 | 545 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002313533.1 | 0 | 46 | 191 | 15 | 160 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002313533.1 | 0 | 180 | 409 | 228 | 457 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002523703.1 | 0 | 46 | 191 | 64 | 209 | alpha-l-fucosidase, putative [Ricinus communis] |
| RefSeq | XP_002523703.1 | 0 | 188 | 431 | 285 | 530 | alpha-l-fucosidase, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3uet_B | 0 | 45 | 190 | 19 | 164 | A Chain A, Crystal Structure Of Alpha-1,34-Fucosidase From Bifidobacterium Longum Subsp. Infantis D172aE217A MUTANT COMPLEXED WITH LACTO-N- Fucopentaose Ii |
| PDB | 3uet_B | 3e-26 | 180 | 401 | 257 | 473 | A Chain A, Crystal Structure Of Alpha-1,34-Fucosidase From Bifidobacterium Longum Subsp. Infantis D172aE217A MUTANT COMPLEXED WITH LACTO-N- Fucopentaose Ii |
| PDB | 3uet_A | 0 | 45 | 190 | 19 | 164 | A Chain A, Crystal Structure Of Alpha-1,34-Fucosidase From Bifidobacterium Longum Subsp. Infantis D172aE217A MUTANT COMPLEXED WITH LACTO-N- Fucopentaose Ii |
| PDB | 3uet_A | 3e-26 | 180 | 401 | 257 | 473 | A Chain A, Crystal Structure Of Alpha-1,34-Fucosidase From Bifidobacterium Longum Subsp. Infantis D172aE217A MUTANT COMPLEXED WITH LACTO-N- Fucopentaose Ii |
| PDB | 3ues_B | 0 | 45 | 190 | 19 | 164 | A Chain A, Crystal Structure Of Alpha-1,34-Fucosidase From Bifidobacterium Longum Subsp. Infantis Complexed With Deoxyfuconojirimycin |
