| Basic Information | |
|---|---|
| Species | Ricinus communis |
| Cazyme ID | 30147.m014011 |
| Family | GH89 |
| Protein Properties | Length: 809 Molecular Weight: 92665.4 Isoelectric Point: 6.2698 |
| Chromosome | Chromosome/Scaffold: 30147 Start: 3966648 End: 3975307 |
| Description | alpha-N-acetylglucosaminidase family / NAGLU family |
| View CDS | |
| External Links |
|---|
| NCBI Taxonomy |
| Plaza |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
 | |||
| Family | Start | End | Evalue |
| GH89 | 96 | 797 | 0 |
| PEIIISGVNGMEVVAGLHWYLKYWCGSHISWDKTGGAQLNSIPKLGSLPHVQDAGVLVLRPIPWNYYQNAVTSSYTFAWWDWKRWEKEIDWMALQGINLP LAFTGQEAIWQKVFKKYNLSKVDLDDFFGGPAFLAWSRMGNLHRWGGSLPQSWFFQQLILQKKILARMYELGMNPVLPAFSGNVPAALRNIFPSAKIARL GNWFSVKSDLRWCCTYLLDATDPLFIEIGRAFIEQQLEEYGSTSHIYNCDTFDENTPPVDDPKYISALGAAVFKGMQSGDNDAVWLMQGWLFSYDPFWRP PQMKALLHSVPVGRLVVLDLFAEVKPIWTSSYQFYGVPYIWCMLHNFAGNVEMYGILDSIASGPVEARTSENSTMVGVGMSMEGIEQNPVVYDLMSEMAF QHKKVDVKAWINLYSTRRYGRSVPSIQDAWDILYHTVYNCTDGAYDKNRDVIVAFPDVNPFYFSVSQKRHHLNGKPVSRRAVLKENSDSYDHPHLWYSTS EVLHALELFITSGEELSGSSTYSYDLVDLTRQALAKYGNELFLKIIESYQANDGNGVASRSQKFLDLVEDMDTLLGCHEGFLLGPWLESAKQLAQDQEQE KQFEWNARTQITMWFDNTEDEASLLHDYGNKYWSGLLQDYYGPRAAIYFKYLIKSLENGKVFPLKDWRREWIKLTNEWQRSRNKFPVKSNGNALIISKWL YD | |||
| Full Sequence |
|---|
| Protein Sequence Length: 809 Download |
| MDSLLPAISV FLLFSIFAFT HSSTIGVGYI SRLLEIQERE RASPSVQLAA ARGVLHRLLP 60 SHSSAFEFRI ISKEQCGGQS CFIIENYPFS TGPVTPEIII SGVNGMEVVA GLHWYLKYWC 120 GSHISWDKTG GAQLNSIPKL GSLPHVQDAG VLVLRPIPWN YYQNAVTSSY TFAWWDWKRW 180 EKEIDWMALQ GINLPLAFTG QEAIWQKVFK KYNLSKVDLD DFFGGPAFLA WSRMGNLHRW 240 GGSLPQSWFF QQLILQKKIL ARMYELGMNP VLPAFSGNVP AALRNIFPSA KIARLGNWFS 300 VKSDLRWCCT YLLDATDPLF IEIGRAFIEQ QLEEYGSTSH IYNCDTFDEN TPPVDDPKYI 360 SALGAAVFKG MQSGDNDAVW LMQGWLFSYD PFWRPPQMKA LLHSVPVGRL VVLDLFAEVK 420 PIWTSSYQFY GVPYIWCMLH NFAGNVEMYG ILDSIASGPV EARTSENSTM VGVGMSMEGI 480 EQNPVVYDLM SEMAFQHKKV DVKAWINLYS TRRYGRSVPS IQDAWDILYH TVYNCTDGAY 540 DKNRDVIVAF PDVNPFYFSV SQKRHHLNGK PVSRRAVLKE NSDSYDHPHL WYSTSEVLHA 600 LELFITSGEE LSGSSTYSYD LVDLTRQALA KYGNELFLKI IESYQANDGN GVASRSQKFL 660 DLVEDMDTLL GCHEGFLLGP WLESAKQLAQ DQEQEKQFEW NARTQITMWF DNTEDEASLL 720 HDYGNKYWSG LLQDYYGPRA AIYFKYLIKS LENGKVFPLK DWRREWIKLT NEWQRSRNKF 780 PVKSNGNALI ISKWLYDKYL RNPDTTYDH |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
 | ||||||||
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam12971 | NAGLU_N | 4.0e-19 | 47 | 127 | 81 | + Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This N-terminal domain has an alpha-beta fold. | ||
| pfam12972 | NAGLU_C | 8.0e-98 | 504 | 799 | 296 | + Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold. | ||
| pfam05089 | NAGLU | 0 | 161 | 497 | 337 | + Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold. | ||
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CBI15090.1 | 0 | 20 | 804 | 21 | 842 | unnamed protein product [Vitis vinifera] |
| GenBank | EEC78143.1 | 0 | 23 | 804 | 19 | 811 | hypothetical protein OsI_17702 [Oryza sativa Indica Group] |
| RefSeq | XP_002280399.1 | 0 | 20 | 804 | 21 | 809 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002318632.1 | 0 | 21 | 809 | 25 | 812 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002511461.1 | 0 | 1 | 809 | 1 | 809 | alpha-n-acetylglucosaminidase, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 2vcc_A | 0 | 48 | 789 | 171 | 866 | A Chain A, Recombinant Horseradish Peroxidase Phe209ser Complex With Benzhydroxamic Acid |
| PDB | 2vcb_A | 0 | 48 | 789 | 171 | 866 | A Chain A, Recombinant Horseradish Peroxidase Phe209ser Complex With Benzhydroxamic Acid |
| PDB | 2vca_A | 0 | 48 | 789 | 171 | 866 | A Chain A, Recombinant Horseradish Peroxidase Phe209ser Complex With Benzhydroxamic Acid |
| PDB | 2vc9_A | 0 | 48 | 789 | 171 | 866 | A Chain A, Family 89 Glycoside Hydrolase From Clostridium Perfringens In Complex With 2-Acetamido-1,2-Dideoxynojirmycin |
| PDB | 4a4a_A | 0 | 48 | 789 | 194 | 889 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
