| Basic Information | |
|---|---|
| Species | Phaseolus vulgaris |
| Cazyme ID | Phvul.009G182100.2 |
| Family | GH89 |
| Protein Properties | Length: 595 Molecular Weight: 69166.9 Isoelectric Point: 5.1267 |
| Chromosome | Chromosome/Scaffold: 09 Start: 26831773 End: 26845064 |
| Description | alpha-N-acetylglucosaminidase family / NAGLU family |
| View CDS | |
| External Links |
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| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GH89 | 1 | 252 | 0 |
| MALQGVNLPLAFTGQEAIWQKVFQEKFNMSMSDLDDFFGGPAFLAWSRMGNLHGWGGPLPQSWFDKQLILQKKILARMYELGMTPVLPAFSGNVPAALKY IFPSAKITRLGNWFSVKNDLKWCCTYLLDATDPLFIEIGKAFIEKQLQEYGRTGHIYNCDTFDENTPPIDDPEYISSLGAATFKGMQSGDDDAVWLMQGW LFSYDPFWRPPQMKALLHSVPLGKLVVLDLFAEVKPIWVTSEQFYGVPYIWK | |||
| GH89 | 253 | 577 | 0 |
| VGVGMSMEGIEQNPIVYDLMSEMAFQQKKIDVKAWVDMYSTRRYGKSLPLIQEGWNVLYHTIYNCTDGAYDKNRDVIVAFPDVDPSLISVQYDQSHHYYR PSGTVIKEITDPFDRPHLWYSTSEVIYALELFITIGDELSRSKTYRYDLVDLTRQVLAKYANELFFKVIEAYKSHDVHGMTLLSQRFLDLVEDLDTLLAC HDGFLLGPWLESAKQLAQNEEQERQFEWNARTQITMWFDNTKEEASLLRDYGNKYWSGLLHDYYGPRAAIYFKYLRESLERGEDFKLIEWRREWIKLTNE WQKSRNTFPVESKGDALNTSRWLFN | |||
| Full Sequence |
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| Protein Sequence Length: 595 Download |
| MALQGVNLPL AFTGQEAIWQ KVFQEKFNMS MSDLDDFFGG PAFLAWSRMG NLHGWGGPLP 60 QSWFDKQLIL QKKILARMYE LGMTPVLPAF SGNVPAALKY IFPSAKITRL GNWFSVKNDL 120 KWCCTYLLDA TDPLFIEIGK AFIEKQLQEY GRTGHIYNCD TFDENTPPID DPEYISSLGA 180 ATFKGMQSGD DDAVWLMQGW LFSYDPFWRP PQMKALLHSV PLGKLVVLDL FAEVKPIWVT 240 SEQFYGVPYI WKVGVGMSME GIEQNPIVYD LMSEMAFQQK KIDVKAWVDM YSTRRYGKSL 300 PLIQEGWNVL YHTIYNCTDG AYDKNRDVIV AFPDVDPSLI SVQYDQSHHY YRPSGTVIKE 360 ITDPFDRPHL WYSTSEVIYA LELFITIGDE LSRSKTYRYD LVDLTRQVLA KYANELFFKV 420 IEAYKSHDVH GMTLLSQRFL DLVEDLDTLL ACHDGFLLGP WLESAKQLAQ NEEQERQFEW 480 NARTQITMWF DNTKEEASLL RDYGNKYWSG LLHDYYGPRA AIYFKYLRES LERGEDFKLI 540 EWRREWIKLT NEWQKSRNTF PVESKGDALN TSRWLFNKYL NLTNTETKLI EVQR* 600 |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam12972 | NAGLU_C | 3.0e-98 | 286 | 579 | 294 | + Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold. | ||
| pfam05089 | NAGLU | 1.0e-139 | 1 | 278 | 311 | + Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold. | ||
| Annotations - NR Download unfiltered results here | |||||||
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| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CAE04506.2 | 0 | 1 | 581 | 190 | 808 | OSJNBb0059K02.16 [Oryza sativa (japonica cultivar-group)] |
| GenBank | EEE61812.1 | 0 | 1 | 581 | 490 | 1108 | hypothetical protein OsJ_16433 [Oryza sativa Japonica Group] |
| RefSeq | XP_002280399.1 | 0 | 1 | 580 | 188 | 805 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002318632.1 | 0 | 1 | 585 | 191 | 809 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002511461.1 | 0 | 1 | 585 | 187 | 805 | alpha-n-acetylglucosaminidase, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
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| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 2vcc_A | 0 | 2 | 591 | 298 | 888 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
| PDB | 2vcb_A | 0 | 2 | 591 | 298 | 888 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
| PDB | 2vca_A | 0 | 2 | 591 | 298 | 888 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
| PDB | 2vc9_A | 0 | 2 | 591 | 298 | 888 | A Chain A, Family 89 Glycoside Hydrolase From Clostridium Perfringens In Complex With 2-Acetamido-1,2-Dideoxynojirmycin |
| PDB | 4a4a_A | 0 | 2 | 591 | 321 | 911 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
| Hydropathy |
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| EST Download unfiltered results here | ||||
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| Hit | Length | Start | End | EValue |
| HO783128 | 418 | 162 | 546 | 0 |
| GW865336 | 302 | 56 | 324 | 0 |
| EE606688 | 251 | 1 | 251 | 0 |
| HO783455 | 321 | 121 | 402 | 0 |
| HO783455 | 133 | 423 | 555 | 0 |
| Sequence Alignments (This image is cropped. Click for full image.) |
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