| Basic Information | |
|---|---|
| Species | Brassica rapa |
| Cazyme ID | Bra021811 |
| Family | GT47 |
| Protein Properties | Length: 810 Molecular Weight: 92670 Isoelectric Point: 6.7839 |
| Chromosome | Chromosome/Scaffold: 04 Start: 14646025 End: 14650467 |
| Description | galactosyltransferase 13 |
| View CDS | |
| External Links |
|---|
| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GT47 | 66 | 410 | 0 |
| CTGRYVYIHNLPSRFNDDLIESCESYAGLRNKCKYLVNSGFGPPILEDDHNHTTRVLTTETGSWHSTNQFMLEVIFREKMRHYECLTNDSSLSSAVFVPF YAGFDVRRFWVYNVKLRDQLGEDLAQWLRERPEWKKMYGQDHFFVTGRVGRDFRRVPDLDSDWGNNLMRLPEFENMTMLSIETNSCSNEFAVPYPTYFHP KTRTEVETWQMQVGTVQRRYLFSFVGAPRPEMEESIRGEVIKQCLASQERCMFLNCDTPSKDCGNPVKVVEVFQDSIFCLQPSGDTPTRRSTFDSVLAGC IPVFFSLDSVQYKWHFPVDHTKYSVYISEEDVRDGKVSIEKILSM | |||
| Full Sequence |
|---|
| Protein Sequence Length: 810 Download |
| MKKFNSRKRK VVRKQSPNLL IYILPTLVFC VLFVPHINQT VTYLFPSDQE TLNLTLKIKQ 60 GETDTCTGRY VYIHNLPSRF NDDLIESCES YAGLRNKCKY LVNSGFGPPI LEDDHNHTTR 120 VLTTETGSWH STNQFMLEVI FREKMRHYEC LTNDSSLSSA VFVPFYAGFD VRRFWVYNVK 180 LRDQLGEDLA QWLRERPEWK KMYGQDHFFV TGRVGRDFRR VPDLDSDWGN NLMRLPEFEN 240 MTMLSIETNS CSNEFAVPYP TYFHPKTRTE VETWQMQVGT VQRRYLFSFV GAPRPEMEES 300 IRGEVIKQCL ASQERCMFLN CDTPSKDCGN PVKVVEVFQD SIFCLQPSGD TPTRRSTFDS 360 VLAGCIPVFF SLDSVQYKWH FPVDHTKYSV YISEEDVRDG KVSIEKILSM ISEEEILSMR 420 NEVEKIIPKI IYAKPGALGP EKIEDAFEIA LPRQLLMERE TEPSSSTKLR RGDREEEDVK 480 VIEWEEFDNE LTRLWSLSSA LKLATEKKLT LQPKLESLIQ VSAESLRRTN ELEEMRQRLE 540 AKKLMVDKTS VTCKVTEQDV KKKEDDLSAE VRSLLVGGTT LSIAKTKLQE SNCQLEGESG 600 YSHLKTVTNK LRKRQQYMVS QVSFIYPLKI EAGPSQDQEL ESFPGGSRLG TKPVSQGSVR 660 ILGLPFSMAP FTKMSFFTDK KEVQKSATAL GYVAHAVSLL APYLGVPIRY PLRLGGSKTY 720 IRDYAPYIEP SASDMSPVST LSENAKFVEF PLFLDGQDTT RAAYAVFLLN KNIEQLLNFV 780 GESSLGPRQV LANLKELIRI IQSPDFIYS* 840 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam10186 | Atg14 | 2.0e-5 | 523 | 777 | 265 | + UV radiation resistance protein and autophagy-related subunit 14. The Atg14 or Apg14 proteins are hydrophilic proteins with a predicted molecular mass of 40.5 kDa, and have a coiled-coil motif at the N terminus region. Yeast cells with mutant Atg14 are defective not only in autophagy but also in sorting of carboxypeptidase Y (CPY), a vacuolar-soluble hydrolase, to the vacuole. Subcellular fractionation indicate that Apg14p and Apg6p are peripherally associated with a membrane structure(s). Apg14p was co-immunoprecipitated with Apg6p, suggesting that they form a stable protein complex. These results imply that Apg6/Vps30p has two distinct functions: in the autophagic process and in the vacuolar protein sorting pathway. Apg14p may be a component specifically required for the function of Apg6/Vps30p through the autophagic pathway. There are 17 auto-phagosomal component proteins which are categorized into six functional units, one of which is the AS-PI3K complex (Vps30/Atg6 and Atg14). The AS-PI3K complex and the Atg2-Atg18 complex are essential for nucleation, and the specific function of the AS-PI3K apparently is to produce phosphatidylinositol 3-phosphate (PtdIns(3)P) at the pre-autophagosomal structure (PAS). The localisation of this complex at the PAS is controlled by Atg14. Autophagy mediates the cellular response to nutrient deprivation, protein aggregation, and pathogen invasion in humans, and malfunction of autophagy has been implicated in multiple human diseases including cancer. This effect seems to be mediated through direct interaction of the human Atg14 with Beclin 1 in the human phosphatidylinositol 3-kinase class III complex. | ||
| pfam03016 | Exostosin | 6.0e-62 | 66 | 408 | 357 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | AAC04487.2 | 0 | 535 | 773 | 1 | 239 | hypothetical protein [Arabidopsis thaliana] |
| RefSeq | NP_001031467.1 | 0 | 535 | 807 | 1 | 273 | unknown protein [Arabidopsis thaliana] |
| RefSeq | NP_180833.1 | 0 | 1 | 455 | 1 | 457 | exostosin family protein [Arabidopsis thaliana] |
| RefSeq | NP_180834.1 | 0 | 14 | 455 | 3 | 471 | exostosin family protein [Arabidopsis thaliana] |
| RefSeq | NP_850197.1 | 0 | 457 | 807 | 1 | 349 | unknown protein [Arabidopsis thaliana] |
