Basic Information | |
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Species | Citrus clementina |
Cazyme ID | Ciclev10014440m |
Family | CBM43 |
Protein Properties | Length: 712 Molecular Weight: 78576.5 Isoelectric Point: 6.7505 |
Chromosome | Chromosome/Scaffold: 2 Start: 35429103 End: 35435228 |
Description | endonuclease/exonuclease/phosphatase family protein |
View CDS |
External Links |
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CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH17 | 31 | 104 | 2.4e-21 |
VGVNIGTDVSNLLSPTDLVSFLQVQKITHIRLYDADPDLLKALAKTKIRVIVSVPNNQLLAIGSSNTTAASWID | |||
CBM43 | 182 | 263 | 9.7e-34 |
CIAMDAVDTKTLQAALDWACGPGRANCSDIQPGEPCYQPNNVKSHASYAFDSYYHEQGKTSGSCDFKGVAMITTTDPSHGSC |
Full Sequence |
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Protein Sequence Length: 712 Download |
MENPKLTLFI IFYLTVLNTA KAADPDKEPF VGVNIGTDVS NLLSPTDLVS FLQVQKITHI 60 RLYDADPDLL KALAKTKIRV IVSVPNNQLL AIGSSNTTAA SWIDTYNSNL IKHILDRSGT 120 PFHPEVTSNV YIYELFNEDL RSPPISEANW GLFHANTTPV YLLHVSGSGT FLANDTTNQT 180 YCIAMDAVDT KTLQAALDWA CGPGRANCSD IQPGEPCYQP NNVKSHASYA FDSYYHEQGK 240 TSGSCDFKGV AMITTTDPSH GSCIFPGSKK VSNKTKAVVN STQISGAADR LRFISLRGNQ 300 ISANAVAFSI LTRGSSMSSW ACKKCTFLNS PSRKSTCQIC LTPSSSFSPP SKSSVSVPTW 360 SCKACTFLNP YNNTSCELCN TRAPVSGLSS FEDLTDPALD SELDSSVGSV FLPLQLKACT 420 DDTTPGPSAD NSESGAVSGS LKILSYNVWF REDLEMHPRM KTIGDLIQLH SPDIICFQEI 480 TPNIYDILCK SSWWKGYRCS VPNEMADSRG YFCMQLSKLP VKSFTCEPFK NSIMGRELCV 540 AEVEVQEKKP LVVATSHLES PCPGPPTWDQ MFSKERVEQA KEAINLLKKN PNVIFCGDMN 600 WDDKLDSKFP LPDGWVDAWT ELRPGENGWT YDTKSNKMLS GNRTLQKRLD RFICSLRDFK 660 IVRIDMIGVE AIPGLLYVKE KKVRKEMQKL ELPVLPSDHY GLLLTISNNI G* 720 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam00332 | Glyco_hydro_17 | 5.0e-13 | 62 | 161 | 107 | + Glycosyl hydrolases family 17. | ||
cd08372 | EEP | 1.0e-13 | 443 | 706 | 282 | + Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily. This large superfamily includes the catalytic domain (exonuclease/endonuclease/phosphatase or EEP domain) of a diverse set of proteins including the ExoIII family of apurinic/apyrimidinic (AP) endonucleases, inositol polyphosphate 5-phosphatases (INPP5), neutral sphingomyelinases (nSMases), deadenylases (such as the vertebrate circadian-clock regulated nocturnin), bacterial cytolethal distending toxin B (CdtB), deoxyribonuclease 1 (DNase1), the endonuclease domain of the non-LTR retrotransposon LINE-1, and related domains. These diverse enzymes share a common catalytic mechanism of cleaving phosphodiester bonds; their substrates range from nucleic acids to phospholipids and perhaps proteins. | ||
pfam07983 | X8 | 1.0e-22 | 180 | 252 | 78 | + X8 domain. The X8 domain domain contains at least 6 conserved cysteine residues that presumably form three disulphide bridges. The domain is found in an Olive pollen allergen as well as at the C-terminus of several families of glycosyl hydrolases. This domain may be involved in carbohydrate binding. This domain is characteristic of GPI-anchored domains. | ||
smart00768 | X8 | 2.0e-41 | 180 | 265 | 86 | + Possibly involved in carbohydrate binding. The X8 domain, which may be involved in carbohydrate binding, is found in an Olive pollen antigen as well as at the C terminus of family 17 glycosyl hydrolases. It contains 6 conserved cysteine residues which presumably form three disulfide bridges. | ||
cd09080 | TDP2 | 3.0e-79 | 441 | 706 | 272 | + Phosphodiesterase domain of human TDP2, a 5'-tyrosyl DNA phosphodiesterase, and related domains. Human TDP2, also known as TTRAP (TRAF/TNFR-associated factors, and tumor necrosis factor receptor/TNFR-associated protein), is a 5'-tyrosyl DNA phosphodiesterase. It is required for the efficient repair of topoisomerase II-induced DNA double strand breaks. The topoisomerase is covalently linked by a phosphotyrosyl bond to the 5'-terminus of the break. TDP2 cleaves the DNA 5'-phosphodiester bond and restores 5'-phosphate termini, needed for subsequent DNA ligation, and hence repair of the break. TDP2 and 3'-tyrosyl DNA phosphodiesterase (TDP1) are complementary activities; together, they allow cells to remove trapped topoisomerase from both 3'- and 5'-DNA termini. TTRAP has been reported as being involved in apoptosis, embryonic development, and transcriptional regulation, and it may inhibit the activation of nuclear factor-kB. This family belongs to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds. |
Gene Ontology | |
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GO Term | Description |
GO:0004553 | hydrolase activity, hydrolyzing O-glycosyl compounds |
GO:0005975 | carbohydrate metabolic process |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
GenBank | ACU18870.1 | 0 | 319 | 699 | 2 | 393 | unknown [Glycine max] |
EMBL | CBI23232.1 | 2e-30 | 1 | 103 | 11 | 119 | unnamed protein product [Vitis vinifera] |
EMBL | CBI23232.1 | 0 | 104 | 709 | 307 | 961 | unnamed protein product [Vitis vinifera] |
RefSeq | XP_002268030.1 | 0 | 319 | 709 | 2 | 413 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002332611.1 | 0 | 319 | 708 | 2 | 421 | predicted protein [Populus trichocarpa] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 4gz2_B | 3e-17 | 438 | 707 | 7 | 253 | A Chain A, Mus Musculus Tdp2 Excluded Ssdna Complex |
PDB | 4gz2_A | 3e-17 | 438 | 707 | 7 | 253 | A Chain A, Mus Musculus Tdp2 Excluded Ssdna Complex |
PDB | 4gz1_B | 3e-17 | 438 | 707 | 7 | 253 | A Chain A, Mus Musculus Tdp2 Excluded Ssdna Complex |
PDB | 4gz1_A | 3e-17 | 438 | 707 | 7 | 253 | A Chain A, Mus Musculus Tdp2 Excluded Ssdna Complex |
PDB | 4gz0_I | 3e-17 | 438 | 707 | 7 | 253 | A Chain A, Mus Musculus Tdp2 Excluded Ssdna Complex |